- Deprotonation
- Depsipeptide
- Depth filter
- Depth maps
- Depth of discharge
- Depth of field
- Depth of focus
- Depth perception
- Depth sounding
- Derailment
- Derating
- Derivative test
- Derivative-free optimization
- Derivatives
- Derivatization
- Derived set
- Derjaguin approximation
- Dermal equivalent
- Dermal fibroblasts
- Dermatan sulfate
- Dermatitis
- Dermatology
- Dermatomes
- Dermatophyte
- Dermatophytosis
- Dermatoscopy
- Dermis
- Derrick
- Desalination
- Desalter
- Desaturase
- Descaling agent
- Descartes' rule of signs
- Descending aorta
- Descending colon
- Descent
- Descloizite
- Describing function
- Description logic
- Descriptive geometry
- Descriptive research
- Descriptive statistics
- Descriptors
- Desensitization
- Desert rose
- Desert varnish
- Desertification
- Desiccants
- Desiccation
- Desiccation tolerance
- Desiccator
- Design basis accident
- Design brief
- Design document
- Design education
- Design effect
- Design engineer
- Design fiction
- Design flow
- Design for X
- Design for all
- Design for inspection
- Design for the environment
- Design knowledge
- Design language
- Design life
- Design manual for roads and bridges
- Design matrix
- Design of experiments
- Design optimization
- Design paradigm
- Design patent
- Design patterns
- Design prototyping
- Design rationale
- Design research
- Design review
- Design science
- Design space exploration
- Design system
- Design thinking
- Design to cost
- Design tools
- Design-build
- Design-to-cost
- Desizing
- Desktop computer
- Desktop environment
- Desktop metaphor
- Desmin
- Desmoglein
- Desmosomes
- Desolder
- Desorption
- Desorption electrospray ionization
- Desquamation
- Dess-Martin periodinane
- Destructive testing
- Destructor
- Desulfobacterales
- Desulfotomaculum
- Desulfovibrio desulfuricans
- Desulfovibrio vulgaris
- Desulfurization
- Desulfuromonadales
- Detached eddy simulation
- Detailed balance
- Detailed engineering
- Detection limit
- Detector
- Detention basins
- Detention dam
- Detention tanks
- Detergent
- Determinant
- Deterministic
- Deterministic algorithms
- Deterministic automaton
- Deterministic encryption
- Deterministic global optimization
- Deterministic simulation
- Deterministic system
- Detonating cord
- Detonation
- Detonation nanodiamond
- Detonation spraying
- Detonation velocity
- Detonation wave
- Detoxification
- Detrended correspondence analysis
- Detrital
- Detritivores
- Detritus
- Detrusor muscle
- Deuterated solvents
- Deuterium fusion
- Developable surfaces
- Developmental biology
- Developmental disorders
- Developmental robotics
- Developmental systems theory
- Developmental toxicity
- Deviance
- Deviance information criterion
- Deviation
- Device drivers
- Device manufacturers
- Device-to-device
- DeviceNet
- Dew