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Liposomal Nanomedicines
Published in Vladimir Torchilin, Mansoor M Amiji, Handbook of Materials for Nanomedicine, 2011
Peptide hormones, first of all insulin, are among the most broadly used drugs. More recently, peptides such as somatostatin analogs (octretide, lanreotide, vapreotide) become available in the clinic for the treatment of pituitary and gastrointestinal tumors.281 Peptide inhibitors of angiogenesis including endostatin are currently in different stages of clinical trials and show a great promise for cancer treatment.282,283 Research on depsipeptides has also revealed a set of potential anticancer agents.284
Cellular attachment behavior on biodegradable polymer surface immobilizing endothelial cell-specific peptide
Published in Journal of Biomaterials Science, Polymer Edition, 2020
Yuichi Ohya, Kazuki Nishimura, Hiromichi Sumida, Yuta Yoshizaki, Akinori Kuzuya, Atsushi Mahara, Tetsuji Yamaoka
PGDCL-REDV, a copolymer of ε-caprolactone and depsipeptide carrying endothelial cell-specific REDV peptide moieties, was prepared as the materials for the lumen of a biodegradable scaffold for small-caliber blood vessels. The attachment behavior of HUVECs on the surface of the blend polymer film (PGDCL-REDV + PGDCL) was investigated. Cell-specific and sequence-specific recognition of HUVECs and REDV peptide-immobilized surfaces were observed. Moreover, the spreading of HUVECs was also observed on PB(REDV) films. The obtained copolymer film had flexibility and excellent film formation properties and can provide a convenient preparative method for biodegradable surfaces having endothelial cell recognition ability. This method must be suitable to provide tube structures having a lumen with endothelialization activity. We are trying to prepare tubular structures using this copolymer as a lumen of the tube. The evaluation of blood compatibility and patency as a scaffold of small-caliber blood vessels will be reported elsewhere.