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Africa 
- Schlieren photography
- Schmid factor
- Schmidt hammer
- Schmitt trigger
- Schmutzdecke
- Schottky barrier
- Schottky diode
- Schottky effect
- Schur complement method
- Schur complements
- Schur decomposition
- Schwann cells
- Schwannomas
- Schwartz space
- Schwertmannite
- Sci-Hub
- SciDB
- Sciatic nerve
- Sciatica
- Science communication
- Scientific calculator
- Scientific computing
- Scientific law
- Scientific management
- Scientific programming language
- Scientific visualization
- Scientometrics
- Scikit-image
- Scikit-learn
- Scilab
- Scintillation
- Scintillation counters
- Scintillators
- Scipy
- Scissors
- Sclera
- Sclerenchyma
- Sclerodactyly
- Scleroderma
- Sclerometer
- Scleroscope
- Sclerosis
- Sclerostin
- Sclerotherapy
- Scn5a
- Scoliosis
- Scope
- Scopolamine
- Scopus
- Score tests
- Scoria
- Scoring
- Scotch yoke
- Scotoma
- Scotopic vision
- Scott-T transformer
- Scour
- Scouring
- Scram
- Scrambler
- Scramjet
- Scrap
- Scrapie
- Scraping
- Scrapy
- Scratch
- Scratch hardness
- Scree
- Scree plot
- Screed
- Screen filter
- Screen magnifier
- Screen readers
- Screen reading
- Screen time
- Screencast
- Screening
- Screenshots
- Screw axes
- Screw compressor
- Screw gun
- Screw piles
- Screw press
- Screw pumps
- Screw terminal
- Screw theory
- Screw thread
- Screw turbine
- Screws
- Scripting languages
- Scripts
- Scroll compressor
- Scroll wheel
- Scrolling
- Scrub radius
- Scrubber
- Scrubbing
- Scrypt
- Scuba
- Sea
- Sea cliff
- Sea ice
- Sea ice concentration
- Sea ice thickness
- Sea level
- Sea salt
- Sea salt aerosol
- Sea surface
- Sea surface height
- Sea trials
- Seabed mining
- Seaborgium
- Seafloor spreading
- Seagrass
- Seakeeping
- Sealant
- Sealed road
- Sealers
- Seam
- Seaplanes
- Search coil
- Search coil magnetometer
- Search engines
- Searchable symmetric encryption
- Season cracking
- Seasonal adjustment
- Seasonal thermal energy storage
- Seat belt syndrome
- Seat belts
- Seat pitch
- Seawalls
- Seawater
- Seaweed
- Seaweed farming
- Seawifs
- Sebaceous glands
- Sebacic acid
- Seborrheic dermatitis
- Sec-butylamine
- Sec-butylbenzene
- Secant line
- Secant method
- Secoisolariciresinol
- Second derivative
- Second fundamental form
- Second generation biofuels
- Second industrial revolution
- Second law of thermodynamics
- Second moment method
- Second moment of area