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Bio-based Polyamides
Published in Abdullah Al-Mamun, Jonathan Y. Chen, Industrial Applications of Biopolymers and their Environmental Impact, 2020
Figure 3.3 illustrates the steps of manufacturing castor oil-based polyamides 6.10 and 10.10. Starting with the castor oil, which is derived from the seeds of the castor oil plant, alkaline hydrolysis is carried out to produce sebacic acid (C10) from the C18 molecule. Subsequently, petro-based hexamethylenediamine is added for polycondensation to produce PA 6.10. In order to produce completely bio-based PA 10.10, the sebacic acid is processed in additional steps to create decamethylenediamine, which reacts with the sebacic acid in the final polycondensation step, producing PA 10.10.
Introducing a flexible drug delivery system based on poly(glycerol sebacate)-urethane and its nanocomposite: potential application in the prevention and treatment of oral diseases
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Mahtab Tirgar, Hadi Hosseini, Milad Jafari, Shahrokh Shojaei, Amir Abdollahi, Aliakbar Jafari, Lokman Uzun, Vahabodin Goodarzi, Chia-Hung Su
Outstanding flexibility, softness, processability, easy and cost-effective synthesis, along with high compatibility are required parameters for designing an appropriate biomaterials to be applied in soft tissue engineering and drug delivery systems [1–6]. In this regard, poly(glycerol-sebacic) (PGS) acid could be taken into consideration due to its biodegradability, biocompatibility, flexibility and rubber-like behaviors. PGS was first reported in 2002 as a biodegradable polyester based biopolymer for using soft tissue engineering applications [7]. PGS is a new aliphatic, elastomeric polyester that is made from sebacic acid and glycerol [8]. PGS has adjustable properties to specific application by means of changing the molecular weight and cross-linking approaches [9–11]. Since it possesses elastomeric behavior resembling the soft tissue, it is able to provide suitable stability and uniformity of the structure in a dynamic mechanical environment, without agitating the host tissue [12,13]. This endows PGS as a convenient alternative for many medical applications such as drug delivery and tissue regeneration [14]. Pereira [15] repowered a vast range of biodegradable elastomers and their roles in tissue engineering and healing of some body problems. Role of biodegradable elastomers in drug delivery systems has been completely investigated by Amsten [16,17].
Synergic effect of waste PET and sebacic acid on the rheology of crumb rubber modified bitumen
Published in International Journal of Pavement Engineering, 2021
Chandra Sekhar Mohanta, Anand Sreeram, Veena Yadav, Rabindra Kumar Padhan, N. S. Raman, R. P. Badoni
In the modification of bitumen in this study, it is imperative to document that there is the combination of bitumen, crumb rubber (CR), synthesised PET additives and sebacic acid. The chemical structure of sebacic acid with its dicarboxylic acid groups is illustrated in Figure 4. The various blends were prepared to reflect the effects of the additives in combination and separately with CRMB as illustrated in Table 4. Firstly, the neat binder was blended with 10% by weight crumb rubber at 160°C–170°C for one hour using a high shear mixer at a shear rate of 5000 rpm to produce CRMB-1. Subsequently, 0.5% sebacic acid was added to CRMB-1 and blended for another hour at the same temperature to produce CRMB-2. Likewise, 1% and 2% of sebacic acid were added to CRMB-1 to form CRMB-2A and CRMB-2B. Similarly, 0.5%, 1% and 2% of synthesised PET additives were added to CRMB-1 and blended for about one hour to form CRMB-3, CRMB-4 and CRMB-5 respectively. Then 0.5% of sebacic acid was further added to CRMB-3, CRMB-4 and CRMB-5 and blended for one hour to form CRMB-6, CRMB-7 and CRMB-8. Lastly, 1% and 2% of sebacic acid were added to CRMB-3 and blended for one hour to form CRMB-9 and CRMB-10.
Microwave-assisted facile fabrication of porous poly (glycerol sebacate) scaffolds
Published in Journal of Biomaterials Science, Polymer Edition, 2018
Soo Hyon Lee, Kee-Won Lee, Piyusha S. Gade, Anne M. Robertson, Yadong Wang
PGS is a thermoset polyester that has been synthesized mostly by a polycondensation process based on Fischer–Speier esterification. Hydroxyl groups of glycerol react with the carboxylic acid groups of sebacic acid while releasing water molecules [1,17,18]. The advantage of this material is that the monomers (sebacic acid and glycerol), the intermediate (PGS oligomers), and the final polymers, all have good biocompatibility. Most applications using PGS require a curing step to convert PGS from a sticky resin to an elastomer. However, this process is difficult to scale up because of prolonged heating (120–150 °C), high vacuum (less than 25 Torr) and several days of reaction time [1,18].