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Lignin in Biological Systems
Published in Severian Dumitriu, Valentin Popa, Polymeric Biomaterials, 2020
Flaxseed and its lignan secoisolariciresinol diglucoside (SDG) inhibit mammary tumor development in rats. At the same time, the increased plasma insulin-like growth factor I (IGF-1) concentrations are associated with increased breast cancer risk. The anticancer effect of flaxseed and SDG may be related, in part, to reductions in plasma IGF-I (Rickard et al. 2000).
Styrax camporum, a typical species of the Brazilian cerrado, attenuates DNA damage, preneoplastic lesions and oxidative stress in experimental rat colon carcinogenesis
Published in Journal of Toxicology and Environmental Health, Part A, 2021
Pollyanna Francielli De Oliveira, Luis Fernando Leandro, Ricardo Andrade Furtado, Natália Helen Ferreira, Patrícia Mendonça Pauletti, Alba Regina Barbosa Araújo, Sérgio Akira Uyemura, Denise Crispim Tavares
The metabolism of lignans by the intestine produces estrogen-like structures, including enterodiol and enterolactone. Cordeiro, Fernandes, and Barbosa (2009) demonstrated a relationship between the amount of lignans excreted in urine and the risk of hormone-dependent cancers, especially breast cancer, with a high intake associated with decreased risk of this carcinoma. It is noteworthy that lignans have been associated with cancer chemoprevention in which both lignan and its secoisolariciresinol precursor exert an inhibitory effect on (1) development of new tumors, (2) capturing active chlorine species, (3) reducing local inflammation, (4) suppressing nuclear factor kappa B (NF-κB) signaling, and (5) inhibiting the growth of breast tumors (Bowers et al. 2019; Mishra et al. 2016; Niwa et al. 2016; Padilha and Pinheiro 2004; Saleem et al. 2005; Thompson et al. 1996).