- Space environment
- Space exploration
- Space form
- Space frame
- Space geodesy
- Space groups
- Space habitat
- Space launch
- Space mapping
- Space partitioning
- Space probes
- Space radiation
- Space segment
- Space station
- Space suits
- Space sustainability
- Space telescopes
- Space time adaptive processing
- Space tribology
- Space vector modulation
- Space vehicles
- Space weather
- Space-based solar power
- Space-filling curve
- Space-time adaptive processing
- Spacecraft
- Spacecraft attitude control
- Spacecraft charging
- Spaces
- Spacetime
- Spacetime manifold
- Spacy
- Spall
- Spallation
- Spam
- Spam filter
- Spamming
- Span
- Spanner
- Spanning Tree
- Spanning Tree Protocol
- Spare parts
- Sparging
- Spark
- Spark gap
- Spark ignition
- Spark plasma sintering
- Spark plugs
- Spark-ignition engine
- Spars
- Sparse
- Sparse PCA
- Sparse approximation
- Sparse graphs
- Sparse grids
- Sparse matrix
- Sparse network
- Spasms
- Spatial ability
- Spatial analysis
- Spatial correlation
- Spatial database
- Spatial decision support system
- Spatial disorientation
- Spatial distribution
- Spatial econometrics
- Spatial filters
- Spatial frequency
- Spatial heterogeneity
- Spatial intelligence
- Spatial join
- Spatial light modulator
- Spatial memory
- Spatial multiplexing
- Spatial normalization
- Spatial reference system
- Spatial relation
- Spatial resolution
- Spatial scale
- Spatial statistics
- Spatial summation
- Spatial variability
- Spatialite
- Spatiotemporal database
- Spatiotemporal patterns
- Spawn
- Speaker
- Speaker diarisation
- Speaker recognition
- Spearman's rank correlation coefficient
- Special case
- Special function
- Special functions
- Special linear group
- Special nuclear material
- Special relativity
- Special unitary group
- Specialty chemicals
- Species abundance
- Species diversity
- Species pool
- Specific detectivity
- Specific dynamic action
- Specific energy
- Specific gravity
- Specific heat
- Specific heat capacity
- Specific impulse
- Specific modulus
- Specific rotation
- Specific speed
- Specific storage
- Specific strength
- Specific surface
- Specific surface area
- Specific ultraviolet absorbance
- Specific volume
- Specific weight
- Specification and description language
- Specification language
- Specification tree
- Specifications
- Specificity
- Specificity constant
- Specified minimum yield strength
- Specimens
- Specint
- Speck
- Speckle
- Speckle tracking echocardiography
- Spectator ligand
- Spectrahedron
- Spectral acceleration
- Spectral bands
- Spectral centroid
- Spectral clustering
- Spectral density
- Spectral density estimation
- Spectral efficiency
- Spectral element method
- Spectral flatness
- Spectral flux
- Spectral gap
- Spectral graph theory
- Spectral imaging
- Spectral interferometry
- Spectral leakage
- Spectral methods
- Spectral radiance
- Spectral radius