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Prostate Cancer
Published in Karl H. Pang, Nadir I. Osman, James W.F. Catto, Christopher R. Chapple, Basic Urological Sciences, 2021
Karl H. Pang, James W.F. Catto
Intraductal carcinoma (WHO 2016 new entity).Intra-acinar and/or intraductal neoplastic epithelial proliferation that has some features of HGPIN but exhibits greater architectural and/or cytological atypia.
Chronic erythematous rash and lesions on trunk and limbs
Published in Richard Ashton, Barbara Leppard, Differential Diagnosis in Dermatology, 2021
Richard Ashton, Barbara Leppard
This is due to invasion of the skin around the nipple by malignant cells derived from an intraductal carcinoma. There is a unilateral red scaly plaque surrounding the nipple with or without crusting. It gradually increases in size and is often mistaken for eczema. The fact that it is unilateral and does not respond to topical steroids should alert you to the diagnosis, which can be confirmed by a skin biopsy. Patients should be referred to a breast surgeon.
Pathology of Breast Cancer
Published in Raymond Taillefer, Iraj Khalkhali, Alan D. Waxman, Hans J. Biersack, Radionuclide Imaging of the Breast, 2021
Papillary carcinoma is also associated with a good prognosis. It often occurs in postmenopausal women and may also develop in male breast [110,111]. As a variant of an intraductal carcinoma, papillary carcinoma may cause bloody nipple dischaige, skin dimpling, and nipple retraction or deviation.
Importance of long-term monitoring of patients with breast reconstructions: a case of 10-year cancer recurrence
Published in Case Reports in Plastic Surgery and Hand Surgery, 2022
Sarah Hardwick, Sanjeev Hariparsad, Nakul Kain, Charles M. Malata
Locoregional recurrence risk in the reconstructed breast is similar to the risk after mastectomy alone, and reconstruction is not considered an oncologically provocative additional risk [24,25]. A retrospective review of 554 mammograms in 256 women who underwent TRAM flap reconstruction concluded that annual mammography in all autologous tissue based breast reconstructions yielded low additional detection rate of clinically occult malignancy, and concluded routine surveillance would not be beneficial [26]. The onus is therefore on individual treating physicians to proactively ensure recurrence is detected. This patient’s recurrence, occurring 10 years after primary oncological surgery, demonstrates the ongoing risk, and the role that plastic surgeons, who may see patients later in their recovery for delayed reconstruction, can fill in emphasising this ongoing risk. Whilst evidence to date argues against routine imaging screening in cancer patients who undergo ipsilateral breast reconstruction, late recurrence is still well-documented; Case reports of late recurrence post reconstruction have been published following DIEP flaps at 3 and 9 years post mastectomy in patients treated for intraductal carcinoma [15].
Fertility preservation with random-start controlled ovarian stimulation and embryo cryopreservation for early pregnancy-associated breast cancer
Published in Gynecological Endocrinology, 2019
Nigel Pereira, Isaac Kligman, Rosalie Hunt, Rohini Kopparam, Bridget Wahmann, Zev Rosenwaks
A 34-year-old nulliparous woman had incidentally discovered a breast mass during the fifth week of her pregnancy. She did not have a personal or family history of breast, colon or endometrial cancer. The patient underwent a biopsy of the mass; histopathology revealed an infiltrating intraductal carcinoma, which was estrogen receptor (ER) positive, progesterone receptor (PR) positive and human epidermal growth factor receptor-2 (HER-2) negative. She tested negative for BRCA1 and BRCA2 mutations. Urgent neoadjuvant chemotherapy was deemed necessary. Termination of the pregnancy was offered, which she accepted. The patient presented to our center 5 days after the pregnancy termination to discuss fertility preservation options. Her initial transvaginal pelvic sonogram revealed a thickened endometrial lining and ∼10 antral follicles in each ovary. Her body mass index was 33.3 kg/m2. Her beta-human chorionic gonadotropin (β-hCG) level was 119.8 mIU/mL, progesterone (P) level was 1.2 ng/mL, and anti-müllerian hormone (AMH) level was 3.4 ng/mL on the day of the initial consultation. Fertility preservation options of oocyte and embryo were discussed with the patient and her partner; they chose the latter.
Prostate cancer with cribriform morphology: diagnosis, aggressiveness, molecular pathology and possible relationships with intraductal carcinoma
Published in Expert Review of Anticancer Therapy, 2018
Rodolfo Montironi, Alessia Cimadamore, Silvia Gasparrini, Roberta Mazzucchelli, Matteo Santoni, Francesco Massari, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli
The differential diagnoses of cribriform PCa include benign (normal central zone glands, clear cell cribriform hyperplasia, basal cell hyperplasia with cribriform pattern) and neoplastic (cribriform high-grade prostatic intraepithelial neoplasia and intraductal carcinoma of the prostate) lesions (Table 1). These conditions can be recognized histologically. However, the distinction between small cribriform PCa (GP 3 in 2005 ISUP classification) and cribriform high-grade prostatic intraepithelial neoplasia may be difficult and is based on the absence or presence of basal cells investigated immunohistochemically. When cribriform and intraductal carcinoma cannot be distinguished morphologically, immunohistochemistry for basal cell markers needs to be applied especially if the tissue originates from a biopsy. The presence of basal cells supports a diagnosis of intraductal carcinoma of the prostate (IDC-P).