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Less Common Lung and Bronchial Tumours; Bronchiolo-Alveolar Ca., Carcinoids, Hamartomas, Reticuloses, Protein Disorders, Lung Deposits and Leukaemia.
Published in Fred W Wright, Radiology of the Chest and Related Conditions, 2022
Haemangiopencytomas may arise in most tissues of the body, and in the thorax may arise in the lung, pleura or chest wall. Within the lung most arise centrally and present as well defined solid masses. They later spread in all directions towards the lung periphery. Some arise in previously irradiated tissue. Both the primary tumours and secondary nodal deposits may exhibit speckled calcification. Most are very vascular and give rise to a 'blush' on angiography or enhance with IV contrast agents on CT examinations. A biopsy may give rise to considerable pain. Those arising outside the lungs not uncommonly give rise to lung deposits. A case in a young woman arose bilaterally from the subclavian arteries and caused bilateral Pancoast-like masses, with bilateral Pancoast syndromes. Two cases occurring in the external temporal fossae have lasted 10 and 30 years, both with metastases.
Pathology of Breast Cancer
Published in Raymond Taillefer, Iraj Khalkhali, Alan D. Waxman, Hans J. Biersack, Radionuclide Imaging of the Breast, 2021
It is equally important to realize that in nonsurgical biopsy procedures, the possibility of sampling error can never be completely excluded. Thus, it is essential to recommend further workup and/or close follow-up if the radiologic and pathologic findings do not correlate.
Advanced Ensemble Machine Learning Model for Balanced BioAssays
Published in Rohit Raja, Sandeep Kumar, Shilpa Rani, K. Ramya Laxmi, Artificial Intelligence and Machine Learning in 2D/3D Medical Image Processing, 2020
Lokesh Pawar, Anuj Kumar Sharma, Dinesh Kumar, Rohit Bajaj
The biopsy could be a diagnostic assay which will be a procedure to obviate a bit of tissue or a sample of cells from the body to be analyzed during a laboratory. If an individual is experiencing signs and symptoms, or if the doctor has discovered an area of concern, a diagnostic assay may be ordered to figure out whether or not cancer is present or it is due to another condition [7]. While imaging tests, like X-rays, square measure useful in detective work lots or areas of abnormality, they alone cannot differentiate cancerous cells from noncancerous cells. For the bulk of cancers, the sole thanks to building a definitive designation are to perform a diagnostic test to gather cells for closer examination.
Assessment of complications after transperineal and transrectal prostate biopsy using a risk-stratified pathway identifying patients at risk for post-biopsy infections
Published in Scandinavian Journal of Urology, 2023
Sebastian Berg, Karl Heinrich Tully, Vincent Hoffmann, Henning Bahlburg, Florian Roghmann, Guido Müller, Joachim Noldus, Moritz Reike
Post-biopsy complications were collected between 12 and 14 days after the given procedure. Patients were contacted by phone or seen in the outpatient clinic and asked for post-biopsy complications such as ‘fever’ (≥38.5 °C), ‘prolonged gross hematuria’ (more than 72 h and/or need for catheterization), ‘prolonged rectal bleeding’ (more than 72 h), ‘urinary retention’ (with the need for catheterization), ‘further antibiotic treatment’, ‘suprapubic catheterization’, ‘readmission’ (explicitly due to post-biopsy complications), and ‘others’. For the final analysis, ‘fever’, ‘antibiotic treatment’, and ‘suprapubic catheter’ were defined as infectious complications. Patients with missing information on the above-mentioned covariables, missing consent as well as lost to follow-up were excluded from further analyses.
Progress in understanding primary glomerular disease: insights from urinary proteomics and in-depth analyses of potential biomarkers based on bioinformatics
Published in Critical Reviews in Clinical Laboratory Sciences, 2023
Lili Ge, Jianhua Liu, Baoxu Lin, Xiaosong Qin
In the past few decades, chronic kidney disease (CKD) has become a global public health challenge [1]. The prevalence of CKD is high, between 11 and 13%, and glomerular disease (GD), especially primary glomerular disease (PGD), is one of the most common causes of CKD [2]. Patients with PGD may develop end-stage renal disease (ESRD) [3]. Determining the pathological type of PGD together with understanding the pathogenesis of the disease is therefore pertinent and conducive to treatment. However, the invasive method of renal biopsy remains the gold standard for determining the pathological type of PGD, and there is a lack of painless diagnostic methods for PGD. Renal biopsy is challenging for patients with severely impaired renal function. Risks associated with renal biopsy include bleeding, pain, infection and kidney vein thrombosis. Problems with biopsy include lack of glomeruli in the tissue obtained, and the sampling site not being reflective of the overall lesion in the kidney. Repeated renal biopsies to monitor disease progression cannot be performed because of the significant risks of bleeding and kidney vein thrombosis. Thus there is great interest in identifying biomarkers for the diagnosis of PGD.
A case of pleomorphic adenoma of the lacrimal gland invading the lower orbit
Published in Orbit, 2022
Ryosei Kado, Satoru Kase, Yuka Suimon, Susumu Ishida
On MRI, common pleomorphic adenoma is round or oval and localized in the lacrimal gland. On the other hand, pleomorphic adenoma in this case was unique, showing a large multinodular gourd-shaped configuration on coronal section MRI. The differential diagnoses included intraorbital hematoma, malignant lymphoma, and epithelial tumors including adenoid cystic carcinoma. In this case, it was difficult to diagnose pleomorphic adenoma preoperatively as the imaging findings were different from those of typical pleomorphic adenoma. Therefore, biopsy could be considered for making a correct diagnosis and determining eventual treatments. However, for pleomorphic adenoma, biopsy is often avoided, as it may damage the capsule, disseminate tumor cells, and lead to recurrence during long-term follow-up periods7 and subsequent malignant transformation.2 In this case, we successfully resected the total tumor and diagnosed it as pleomorphic adenoma. This report highlights the fact that ophthalmologists should keep variations of tumor configurations in mind, and consider total removal without incisional biopsy when pleomorphic adenoma is suspected.