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Topical Photodynamic Therapy for Skin Diseases: Current Status of Preclinical and Clinical Research, Nanocarriers and Physical Methods for Photosensitizer Delivery
Published in Andreia Ascenso, Sandra Simões, Helena Ribeiro, Carrier-Mediated Dermal Delivery, 2017
Fabíola Silva Garcia Praça, Patricia Mazureki Campos, Josimar O. Eloy, Raquel Petrilli, Maria Vitória Lopes Badra Bentley, Wanessa Silva Garcia Medina
An industry-sponsored multicenter study was published in 2007 by Rhodes et al. The authors compared 5-year lesion recurrence rates in nodular basal cell carcinoma treated with topical MAL-PDT or simple excise surgery. Excellent cosmetic outcome: 87% versus 54% was achieved for MAL-PDT and excision surgery, respectively [32].
Diagnostic clues and management rules
Published in Iris Zalaudek, Giuseppe Argenziano, Jason Giacomel, Dermatoscopy of Non-Pigmented Skin Tumors, 2016
Melanoma may also mimic nodular basal cell carcinoma. Although nodular basal cell carcinoma is generally submitted for histopathological examination, the urgency of appointment would differ between basal cell carcinoma and nodular melanoma. While branching and focused vessels are the hallmark of nodular basal cell carcinoma, nodular melanoma more commonly shows linear microvessels over a pink background (Figure 33.6).
Basal cell carcinoma within nevus sebaceous of the trunk
Published in Baylor University Medical Center Proceedings, 2019
Ian T. Watson, Andrew DeCrescenzo, So Yeon Paek
An 82-year-old woman presented to the dermatology outpatient clinic for full-body skin examination. An irregularly shaped, approximately 18 cm × 8 cm, light brown verrucous plaque in a Blaschkoid pattern was identified on the right upper back (Figure 1). The patient stated that the lesion had been present since birth and denied symptoms. Upon dermoscopic evaluation, several pearly papules were appreciated within the large plaque. Shave biopsy of a suspicious papule within the plaque revealed nodular basal cell carcinoma (BCC) on histopathology (Figure 2a). Background NS was also noted on histopathology (Figure 2b). Additional biopsies taken within the lesion further demonstrated nodular and superficial BCCs, trichilemmoma, and tumor of the follicular infundibulum with background NS. In total, five BCCs were diagnosed within this patient’s NS, which were treated with elliptical excision and topical imiquimod. She did not demonstrate additional features of Schimmelpenning syndrome or phakomatosis pigmentokeratotica.
Basal cell carcinoma with extensive periorbital involvement response to vismodegib
Published in Orbit, 2021
Marissa K. Shoji, Nathan Pirakitikulr, Ann Q. Tran, Sara T. Wester
A 73-year-old woman presented with an ulcerated lesion involving her forehead, glabella, and upper eyelids with progressive enlargement over 19 years (Figure 1A). Incisional biopsy demonstrated islands of basaloid epithelial cells with peripheral palisading indicating nodular basal cell carcinoma (BCC). Due to the lesion’s extent, she was started on vismodegib with evidence of granulation tissue in the tumor area after 10 weeks, a significant clinical response (Figure 1B). She subsequently underwent radiotherapy for definitive treatment.
Reconstruction of extensive medial canthal defects using a single V-Y, island pedicle flap
Published in Orbit, 2018
Christopher M. Stewart, Jonathan H. Norris
Presented is a retrospective audit, over a three-year period, of 11 patients who underwent removal of a skin malignancy at the medial canthus. Ten procedures were performed using MOHS micrographic surgery and one by frozen section margin-controlled excision. Histology ranged from nodular basal cell carcinoma (n = 6), nodulo-infiltrative basal cell carcinoma (n = 4), and squamous cell carcinoma (n = 1).