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Nanoparticulate Nanocarriers in Drug Delivery
Published in Anil K. Sharma, Raj K. Keservani, Rajesh K. Kesharwani, Nanobiomaterials, 2018
Raj K. Keservani, Anil K. Sharma, Rajesh K. Kesharwani
Thus, drug delivery to this organ is a challenge, because the brain benefits from very efficient protection. Nanotechnology offers a solution for using the numerous chemical entities for treating brain disorders that are not clinically useful because of the presence of the blood–brain barrier. Nanoparticles can be effectively used to deliver relevant drugs to the brain (Pardridge, 1999). The protein albumin has been modified to create novel nanostructures for applications in drug delivery. The surface of albumin has several groups available for covalent conjugation of biomolecules and drugs. Albumin-DNA-polyethylenimine (PEI) conjugates have been used for gene delivery, with reduced irritation, damage and toxicity (Li, 2008).
Modification of polyethersulfone membranes by Polyethyleneimine (PEI) grafted Silica nanoparticles and their application for textile wastewater treatment
Published in Environmental Technology, 2023
Dalya D. Al-Araji, Faris H. Al-Ani, Qusay F. Alsalhy
Utilizing polymeric grafting technique on the inorganic material surface has been suggested as an efficient possible route to achieve this target. Polyethyleneimine (PEI) is a well-known hydrophilic polymeric material with an extensive amine group along its backbone. Because of its unique properties, branched PEI has a wide range of applications, including surface modification [29, 30]. PEI is a promising organic employed for nanomaterial modification to enhance their stability and dispersion within membrane matrix, as well as to optimize their imparted hydrophilic and antifouling properties [26]. Zhang et al. [29] utilized hyperbranched PEI to modify graphene oxide (GO), which was then embedded into a polyethersulfone (PES) casting solution. Results concluded that PEI has improved the compatibility between GO nanosheets and polymer macromolecules along with providing the membrane with superior antifouling performance [31]. Zargar et al. studied the influence of PEI modified Silica NPs loading content (0.025, 0.05, and 0.1) wt. % on the thin-film nanocomposite (TFN) membranes. Fabricated TFN membranes demonstrated increased hydrophilicity and mechanical resistance, as well as water permeability by 46% [29].
Recent advances of polymer based nanosystems in cancer management
Published in Journal of Biomaterials Science, Polymer Edition, 2023
Chetan Janrao, Shivani Khopade, Akshay Bavaskar, Shyam Sudhakar Gomte, Tejas Girish Agnihotri, Aakanchha Jain
Polyethyleneimine (PEI) is a synthetic cationic homopolymer that has FDA approval for use in biomedical applications. PEI contains repeated units of ethylene and amino groups. It is a component of nanoparticles (NPs) with a strong nucleic acid complexation capability and can be used as a transfection agent. The endosomal/lysosomal pathway can efficiently utilize PEI's excellent water solubility and natural pH buffering capacity. There are some limitations to the clinical usage of PEI such as having harmful effects on cells due to non-biodegradability. With the conjugation of PEI to other polymers, such as cyclodextrins, HA, and PEG, the toxicity concern can be resolved [87]. In vitro testing on MCF-7 cells revealed an improvement in the anticancer effect when PEI was used as a co-delivery mechanism for the delivery of DOX [88]. PEI has also been reported to successfully deliver siRNA to the target in gene therapy as a co-delivery strategy, boosting cytotoxicity and preventing tumor growth [89,90].
Surface modification of ureteral stents: development history, classification, function, and future developments
Published in Expert Review of Medical Devices, 2023
Kaiguo Xia, Xudong Shen, Xiaojie Ang, Bingbing Hou, Yang Chen, Kaiping Zhang, Zongyao Hao
In recent years, some scholars have studied grafting chemicals on the surface of ureteral stents to prevent stent encrustation and achieve better results. Polyethyleneimine (PEI) is a synthetic and nontoxic polymer containing a polycationic structure that comes from primary, secondary, and tertiary amino groups with antibacterial and antifouling properties. Gultekinoglu M [33,63]et al. covalently linked two different molecular weight PEI chains on the different surfaces of polyurethane (PU) by the “grafting to” approach to obtain a brush-like structure. Then, the PEI brush was alkylated with bromhexine to increase the cationic enhancement to the destruction of the bacterial membrane, and the experimental results showed that the surface crusting of the ureteral stent after PEI grafting was significantly reduced. Awonusi BO et al. [64] immobilized Hep/PLL-Cu nanoparticles on dopamine-coated polyurethane surfaces (PU/NPs) and found that the coated stent could inhibit Proteus mirabilis proliferation and biofilm formation, and reduced Ca and Mg salt deposition after in vitro and in vivo experiments.