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Tissue Engineering and Regenerative Medicine
Published in Yaser Dahman, Biomaterials Science and Technology, 2019
Stem cell transplantation, however, is an interesting new field of medicinal research that differs slightly from the tissue engineering aspects of other regenerative medicine approaches. Stem cell therapy is the use of stem cells to prevent or treat a disease or degenerative condition (National Cancer Institute, 2013). Stem cell transplantation, in basic terms, is the infusion of healthy stem cells to replace diseased or damaged ones (Murnaghan, 2016). If successful, the healthy stem cells will integrate into the body and give rise to more cells that are able to perform the necessary functions of a specific tissue.
Micro- and Nanotechnology in Tissue Engineering
Published in Yubing Xie, The Nanobiotechnology Handbook, 2012
Jane Wang, Robert Langer, Jeffrey T. Borenstein
Stem cell therapy appears to be a promising route of therapy for many diseases. With advancing knowledge of stem cell behavior and optimization of culture conditions, construction of the aforementioned scaffolds with appropriate features and functions is the next critical step toward translation of stem cell therapies to a clinical setting.
Hybrid fractional-order optimal control problem for immuno-chemotherapy with gene therapy and time-delay: numerical treatments
Published in International Journal of Modelling and Simulation, 2023
M. M. Abou Hasan, S. M. AL-Mekhlafi, K. Udhayakumar, F. A. Rihan
In the field of cancer chemotherapeutic modeling, significant work has been done. The model presented by De Pillis et al. [2] involves NK cells, CD8+ T cells, and IL-2 therapy. According to their results, immunotherapy is helpful for patients with low immune efficacy while canceling cancerous tissue when chemotherapy is present. An analysis of radiotherapy followed by chemotherapy was proposed by Liu et al. [11]. A combination of chemotherapy and immunotherapy, single immunotherapy, and single chemo was examined by Pang et al. [12]. Rodrigues et al. [13] presented a significant model that considered chemo-immunotherapy as a method of reducing unwelcome cytotoxic effects on immune cells in cancer patients. A mathematical model for the treatment of cancer using a combination of chemotherapy and stem cell therapy was proposed by Alqudah [14]. As part of the treatment protocol, Dehingi et al. [9] combined chemotherapy with gene therapy and immunotherapy. This paper, however, explores the generalization of the system which was proposed by Dehingi et al. [9].
Effects of zinc on expression of apoptosis-related genes in freezing thawing damage of adipose tissue derived mesenchymal stromal cells
Published in Preparative Biochemistry & Biotechnology, 2022
Fatemeh Nesari, Mohammadreza Gholami, Jafar Rezaian, Afshin Pirnia, Khatereh Anbari, Masoud Beigi Boroujeni, Mandana Beigi Boroujeni
According to the development of using stem cells in recent years, designing safe and repeatable methods for extraction and preservation of stem cells is of importance.[7] Using freezing techniques (cryopreservation) prevents long term culture and cellular aging.[8] However, cryopreservation is challenging in stem cell research and clinical practice. It seems that frozen-thawed stem cells have reduced immune modulatory and blood regulatory properties compared with fresh stem cells.[9] Regarding the limitations of using fresh and thawed stem cells, it is recommended that our choice should be based on clinical indications of the patients.[10] Hence, researchers tried to study the safety and efficacy of the techniques of stem cell therapy.[11]
Information fusion for future COVID-19 prevention: continuous mechanism of big data intelligent innovation for the emergency management of a public epidemic outbreak
Published in Journal of Management Analytics, 2021
Shi Yin, Nan Zhang, Junfeng Xu
In China, in response to the COVID-19 epidemic, the joint prevention and control mechanism research team has been set up to focus on clinical treatment and drug development, vaccine development, detection technology and products, virus etiology and epidemiology, and animal model construction. Simultaneously, key working groups on drugs, vaccines, traditional Chinese medicine, and big data have been set up to further the scientific research on epidemic prevention and control. In this process, the government, scientific research institutes, universities, and enterprises collaborated and achieved several important achievements in scientific research within a short period of time. A batch of drugs with curative effect, such as Tozumab, were quickly screened. Advances have been made in plasma therapy and stem cell therapy. The COVID-19 preparedness experience shows that emergency innovation and BDII play a key supporting role in preventing and resolving major public health crises. In response to new outbreaks of infectious diseases, it is imperative to conduct big data intelligent emergency response through multi-disciplinary and industry–university–research collaboration. It is worth exploring on how to improve the coordination mechanism of emergency response and consider the advantages of public epidemic outbreak management, science and technology innovation, and big data intelligent in an efficient and coordinated approach. In this study, logistic model was used to reveal the continuous mechanism of BDII for public epidemic outbreak.