Penicillin allergy

Penicillin allergy refers to an adverse immune reaction to the β-lactam class of antibiotics, specifically penicillin, which is reported frequently. However, true penicillin allergy is rare and is estimated to occur in 1-5 out of 10,000 cases of penicillin therapy, with a potential for anaphylaxis.From: Drug-induced and Iatrogenic Respiratory Disease [2010], Determination of antibiotic impurities in good manufacturing practices-grade cell therapy medicinal products [2020]

Drug-induced bronchospasm

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Published in Philippe Camus, Edward C Rosenow, Drug-induced and Iatrogenic Respiratory Disease, 2010

K Suresh Babu, Jaymin Morjaria

Allergy to β-lactam drugs is frequently reported, and in particular penicillin allergy. Severe anaphylactic reactions with β-lactam agents can and do occur but are rare. It was reported that after 32 430 injections of benzathine penicillin during 2736 patient-years of observation, 3.2 per cent had an allergic reaction. Of these reactions, four were anaphylactic, an incidence of 0.2 per cent.16 Despite this rarity, penicillin-induced anaphylaxis continues to be the most common cause of ana-phylaxis in humans, accounting for approximately 75 per cent of fatal anaphylactic cases in the United States each year.7,17

Determination of antibiotic impurities in good manufacturing practices-grade cell therapy medicinal products

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Journal Information

Published in Preparative Biochemistry & Biotechnology, 2020

Olga Nehir Oztel, Seval Korkmaz, Erdal Karaoz

Beta-lactam antibiotics have been commonly used in general practice since their invention; however, most causes of immunological drug reactions are allergic responses to beta-lactams.[32] Hypersensitivity reaction against penicillin application causes anaphylactic reactions in all penicillin modifications. Five to ten percent of patients with penicillin hypersensitivity, especially those with early manifestations, are also hypersensitive to cephalosporins.[33] Adverse reactions to penicillin occur in approximately 10–20% of treatment courses[34–36] and fatal penicillin-induced anaphylaxis occurs at the rate of 0.002% among general population.[34] True penicillin allergy is rare, with an estimated anaphylaxis frequency of 1–5 in 10,000 cases of penicillin therapy.[35]

Penicillin allergy

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Drug-induced bronchospasm

Determination of antibiotic impurities in good manufacturing practices-grade cell therapy medicinal products