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The Gulf War's Troubling Legacy
Published in Peggy Munson, Stricken, 2014
Gulf War syndrome (GWS) is manifested in many ways. Chronic fatigue immune dysfunction syndrome (CFIDS) affects over half of the victims, according to Dr. Garth Nicolson, who, with his wife, molecular biophysicist and University of Texas professor Dr. Nancy Nicolson, has examined and evaluated many syndrome patients.2 Public health expert Dr. Leonard Horwitz estimates that 80 to 90 percent of syndrome patients are plagued with severe aches and pains in their joints.3 Others commonly experience dizziness, nausea, stomach pains, light sensitivity, intense anxiety, breathing difficulty, muscle spasms, diarrhea, blurred vision, inexplicable skin rashes, bleeding gums, eye redness, night sweats, and acute migraine-like headaches. Sexual and urination disorders plague numerous victims, and 25 percent have acquired multiple chemical sensitivities, which means they have become allergic to a wide variety of chemical substances and can consequently have severe reactions to even the most common household items.
Genitourinary syndrome, local oestrogen therapy and endometrial pathology: a single-centre, randomised study
Published in Journal of Obstetrics and Gynaecology, 2022
Stefan Miladinov Kovachev, Miladin Stefanov Kovachev
The genitourinary syndrome affects 20% to 45% of postmenopausal women (Kim et al. 2015; Kagan et al. 2019; Kozma et al. 2019). It includes a combination of symptoms due to low oestrogen levels, such as genital dryness, burning irritation, dyspareunia, genital discomfort and pain, recurrent uroinfections, and urination disorders (dysuria, urgency, dysuria) (Kagan et al. 2019). The embryonic origin of general genital and urinary system complaints should be sought in the Mullerian and Wolffian ducts and the impaired function of oestrogen receptors located in them (Kim et al. 2015). To treat this syndrome, local and oral phytoestrogens, local lubricants and moisturisers, selective oestrogen receptor modulators (SERM), local lasers, and mainly local and oral oestrogens can be used (Tempfer et al. 2007; Kim et al. 2015; Bruyniks et al. 2017; Kagan et al. 2019; Kozma et al. 2019). Oral and transdermal oestrogen therapy, according to the data from various studies, leads to 1%–28% of all cases of endometrial hyperplasia (benign or atypical) and 0.2%–3% of all cases of endometrial neoplasia (Brinton and Felix 2014; Chandra et al. 2016). Topical vaginal oestrogens do not have the same stimulating effect on the endometrium as oral ones, and therefore the association between them and endometrial hyperplasia or cancer has not been established categorically. Vaginal oestrogens cause 0% to 2% of all cases of endometrial hyperplasia and cancer, according to various clinical studies (Simon et al. 2010; Constantine et al. 2019).
Lymphomatosis cerebri with cauda equina lymphoma
Published in International Journal of Neuroscience, 2021
Gang Deng, Ran Tao, Dai-Shi Tian, Jun-Li Liu
PCNSL usually has a subacute or chronic onset, presenting as focal neurological deficit, progressive cognitive dysfunction, or personality changes [12]. Some patients experience increased intracranial pressure or visual disorder(s). Epileptic seizures are rare, and patients may exhibit defecation and urination disorders in the late stages [12]. Approximately 70%–80% of PCNSLs occur in the supratentorial region, such as the deep white matter in the cerebral hemispheres (especially the frontal lobes and temporal lobes), thalamus/basal ganglia region, corpus callosum and near the ventricles [4]. Typically, PCNSL exhibits homogeneous contrast enhancement and significant diffusion restriction [4]. However, nonspecific clinical manifestations and radiological features are not uncommon. Therefore, misdiagnosis and delay in diagnosis is common, which is always fatal in light of the rapid progressive course of this condition. The confirmation of diagnosis primarily depends on biopsy of brain tissue, while sometimes CSF cytology or flow cytometry may reveal tumor cells [13]. A standard treatment for PCNSL has not been determined. MTX-based, multi-agent chemotherapy is currently considered to be the most effective regimen; however, the optimal dose and duration have not been established [12].
Epidemiological study of Spinal Cord Injury individuals from halfway houses in Shanghai, China
Published in The Journal of Spinal Cord Medicine, 2018
Feng-Shui Chang, Qi Zhang, Mei Sun, Hui-Jiong Yu, Long-Jun Hu, Jing-Hua Wu, Gang Chen, Lian-Ding Xue, Jun Lu
The symptoms of spinal cord lesions depend on the extent of the injury or non-traumatic cause, and they can include deficits in the ability to perform basic bodily functions, such as breathing, sensation, bowel and bladder control. Deficit in sensation, or sensory loss, refers to the loss of sensations such as pain, touch or temperature. Deficits in motion, or motor loss, refer to muscle weakness and the inability to use the body. We defined urination disorders as urinary retention, urinary incontinence or both, and disorders of defecation as constipation, fecal incontinence, or both. The SCI complications included bedsores, pain, urinary tract infections, and spasticity. The main medical and rehabilitation treatments received included surgery, medicine, traditional therapy (e.g., acupuncture, moxibustion, and massage), physical therapy, rehabilitation training, assistive devices (e.g., orthosis and prosthesis) and other methods appropriate for SCI individuals.