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Chronic Pain: What Is It?
Published in Michael S. Margoles, Richard Weiner, Chronic PAIN, 2019
Your leg feels “dead.” Your hand is numb and you accidentally burn it on the stove but do not feel the burn. Your foot feels longer than usual. Your skin feels wet but is not. Your arm, leg, hand, torso, or abdomen feels swollen but is not. “Lightening” shoots down your back or extremities when you bend your neck or back. You swell in seemingly odd places. Paresthesias: Morbid or perverted sensation; an abnormal sensation, as burning, prickling, tingling, cramping, etc.Dysesthesias: Unpleasant abnormal sensation produced by normal stimuli. The straps or underwires of a brassiere can become very painful to muscles that have been injured in an accident.. Belts and tight clothes can cause pain.Routine activities can become more painful than expected.Unexplained sensations: Such expressions as “knifelike,” “stabbing,” “crushing,” “burning,” (less often, “freezing”), “a constricting band,” “a storm,” “a shock,” “as if the flesh is being torn away,” and “indescribable” are metaphoric attempts to describe a complex of totally unfamiliar sensory experiences” (Adams and Victor, 1981).
Impairment of functions of the nervous system
Published in Ramar Sabapathi Vinayagam, Integrated Evaluation of Disability, 2019
Sensory perversions comprise paresthesia and dysesthesia. Paresthesia is abnormal sensation evoked without any stimulus. It may be a tactile or thermal or burning sensation. Dysesthesia is a painful sensation evoked by a light touch over the affected area (Tables 6.39 through 6.41).
Discussions (D)
Published in Terence R. Anthoney, Neuroanatomy and the Neurologic Exam, 2017
Most authors describe dysesthesias as elicited abnormal sensations. If thalamic pain is elicited, is it a dysesthesia? Although Margulies does not use the term “dysesthesia” within the context of thalamic lesions, his definition of “thalamic pain”—“when non-painful stimuli become misinterpreted as poorly localized, burning pain” (1986, p. 218)—fits closely the definition of “dysesthesia” given by some other authors (e.g., A&V, p. 123; Ross, p. 235). Adams and Victor 1985) also describe “thalamic pain” (p. 126) as a “dysesthesia” (p. 110). In addition, authors who received their primary medical training in Great Britain may allow “dysaesthesiae” to be spontaneous (see the discussion of Semantic Conflicts 1–3 for citations). Consequently, if such authors also describe thalamic pain as spontaneous, they, too, may consider it to be a dysaesthesia (e.g., Walt, p. 197).
Guillain-Barré syndrome after bortezomib therapy in a child with relapsed acute lymphoblastic leukemia
Published in Pediatric Hematology and Oncology, 2022
Valeria Ceolin, Rosita Cenna, Francesca Resente, Manuela Spadea, Franca Fagioli, Nicoletta Bertorello
Peripheral neuropathy (PN) has been described in patients receiving bortezomib, which is predominantly sensory. Symptoms include paresthesia, numbness in distal areas, particularly the lower limbs, burning sensations, dysesthesias, sensory loss, reduced proprioception, vibratory sensation, reduction of deep tendon reflexes and autonomic skin innervation. Neuropathic pain has also been described and happens more frequently than with other neurotoxic drugs.14 PN usually appears after a number of cycles of treatment and is associated with dose accumulation, but symptoms may also appear after the first few doses; recent studies28 did not find a clear linear correlation between the cumulative dose or dose intensity and the severity of polyneuropathy, indicating that certain patients developed a severe polyneuropathy following a relatively low dose of BZM. The pathophysiology of bortezomib induced neuropathy is not completely clear yet. Experimental studies suggest that aggresome formation, endoplasmic reticulum stress, myotoxicity, microtubule stabilization, inflammatory response, and DNA damage could contribute to this neurotoxicity.29
Bi-needle technique versus transforaminal endoscopic spine system technique for percutaneous endoscopic lumbar discectomy in treating intervertebral disc calcification: a propensity score matched cohort analysis
Published in British Journal of Neurosurgery, 2021
Zeng Xu, Jian-Cheng Zheng, Bin Sun, Ke Zhang, Yun-Hao Wang, Chang-Gui Shi, Hui-Qiao Wu, Xiao-Dong Wu, Hua-Jiang Chen, Wen Yuan
Before propensity score matching, in the Bi-needle group 1, patient had recurrence of symptoms during follow up, after drug therapy the symptoms were relieved (Table 3). In the TESSYS group, three patients had recurrence of symptoms during follow-up, one patient relieved after drug therapy (NSAIDs), two patients finally received open surgery. After propensity score matching, there no patient suffered recurrence in the Bi-needle group and two patients suffered recurrence of symptoms in TESSY group, both of which received posterior open reoperation. Bacterial discitis was diagnosed in one patient in the TESSYS group, there were no patients with postoperative discitis in the Bi-needle group. Cerebrospinal fluid leakage was observed in two patients, one in each matched group, which resulted from wide and firm adhesions between the calcification and nervous tissue. However, the symptom were not severe and resolved within one with bed rest in both cases. Two 2 patients had persistent dysesthesia after surgery in the TESSYS group and they resolved at 1 week and 3 weeks post op. Comparing specific complications, there were no statistically difference between two groups. When all complication were taken together the difference was significant (p < 0.05).
Sensory descriptors which identify neuropathic pain mechanisms in low back pain: a systematic review
Published in Current Medical Research and Opinion, 2020
Michelle Heraughty, Colette Ridehalgh
Seven studies examined dysesthesia, also described as tingling or prickling, as an individual descriptor or in combination28–32,34,35. Gierthmuhlen et al.31 found a higher percentage of participants in the radiculopathy group selected prickling in both the back and leg from a list of descriptors compared to nociceptive LBP group, with no statistical difference between the two sites. Fishbain et al.30 reported the mean scores on a 10 point scale were statistically significantly higher for dysesthesia in the NLBP group compared to nociceptive LBP group (p < .001). El Sissi et al.29 found dysesthesia was chosen by 96% of NLBP patients and was more statistically significantly associated with NLBP compared to nociceptive LBP. Cappelleri et al.28 reported tingling or prickling demonstrated adequate item discrimination (≥0.4) between groups. Sivas et al.35 found NLBP patients chose dysesthesia more frequently compared to nociceptive LBP. They report 85% of patients with NLBP on DN4 chose tingling and 100% of patients with NLBP on the LANSS chose dysesthesia