China
Africa
Explore chapters and articles related to this topic
Dermal Fibroblast Function
Published in Brian J. Nickoloff, Dermal Immune System, 2019
Enzymes synthesized by fibroblasts and other cells are capable of extensive degradation of all matrix components. The matrix metalloproteinases (MMPs) are interstitial collagenase (MMP-1), type IV collagenase (gelatinases, MMP-2), and stromelysins (MMP-3).55 The MMPs are likely the major rate-limiting enzymes controlling extracellular matrix degradation in normal and pathological conditions.55
On the Sophistication of Herbal Medicines
Published in Aruna Bakhru, Nutrition and Integrative Medicine, 2018
After more than a decade of use, we have found this one herb to be foundational for stopping the damage that Borrelia cause, especially in the nervous system. Once the inflammation is stopped, rebuilding the damaged neural structures can occur, restoring function and quality of life. Often, the body's natural repair mechanisms can accomplish this on their own, other times herbs that facilitate the rebuilding of nerve sheaths and other damaged neural structures are necessary. (Some additional MMP-9 inhibitors are Cordyceps, EGCG, NAC, Olea europaea, Punica granatum, Salvia miltiorrhiza, Scutellaria baicalensis. Cordyceps is also a MMP-3 inhibitor; Punica granatum inhibits MMP-1 and -3.)
Complications of Diabetes and Role of a Citrus Flavonoid Nobiletin in its Treatment
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Lokesh K. Bhatt, Parkar A. Nishad, Addepalli Veeranjaneyulu, Ram S. Gaud
Several studies have reported that nobiletin possesses anticancer, antiviral, and anti-inflammatory activity. Nobiletin can inhibit matrix degradation of the articular cartilage, and pannus formation in osteoarthritis and rheumatoid arthritis by inhibiting the production of pro-MMP-9 and prostaglandin E2 (PGE2) in human synovial fibroblasts by selectively down regulating cyclooxygenase-2 (COX-2) activity as seen in anti-inflammatory studies.125 Molecular biological evidence shows that nobiletin suppresses gene expression and production of some matrix metallproteinases (MMP-1, MMP-3, and MMP-9) in rabbit articular chondrocytes and synovial fibroblasts. Another recent work showed that nobiletin caused inhibition of pro-MMP-1 and pro-MMP-3 while it unregulated the endogenous tissue inhibitors of MMPs.126 Further, study on mouse macrophages showed downregulation of gene expression of pro-inflammatory cytokines, such as interleukin: IL-1α, IL-1β, TNF-α, and IL-6.125 Also, inhibitory effects on inducible NOS protein production were observed in mouse macrophages.127
Association of MMP-2, MMP-3, and MMP-9 Polymorphisms with Susceptibility to Recurrent Pregnancy Loss
Published in Fetal and Pediatric Pathology, 2021
Athena Behforouz, Seyed Alireza Dastgheib, Hajar Abbasi, Mojgan Karimi-Zarchi, Atiyeh Javaheri, Amaneh Hadadan, Razieh Sadat Tabatabaei, Bahare Meibodi, Hossein Neamatzadeh
MMP-3 is a considerable risk factor of vascular disorders and coronary heart disease. The promoter region of MMP-3 gene is characterized by a 5A/6A polymorphism at position -1171, which is associated with elevated transcriptional levels and local expression of the MMP-3 gene [33]. Our results support that homozygous MMP-3 rs35068180 polymorphism is significantly associated with increased risk of RPL. However, Pereza et al. [29] have failed to show a significant association between MMP3 -1612 5 A/6A polymorphisms and RPL in a Croatian population. Balci et al. have reported a relatively high level of MMP-3 expression in induced abortion specimens in a group of women with terminated abortions. Therefore, they have suggested that increased levels of MMP-3 might be a predictor of successful implantation, whereas its decreased expression might be indicative of risk for pregnancy loss [34].
Multicenter, observational clinical study of abatacept in Japanese patients with rheumatoid arthritis
Published in Immunological Medicine, 2019
Noriyoshi Ogawa, Hiroyuki Ohashi, Yasuhiro Ota, Kaori Kobori, Motohiro Suzuki, Seiji Tsuboi, Masakatsu Hayakawa, Yoshinori Goto, Taro Karahashi, Osamu Kimoto, Toshiaki Miyamoto, Shogo Furukawa, Kumiko Shimoyama, Daisuke Suzuki, Yuichiro Maekawa
This study also analyzed the associations between treatment efficacy and changes in MMP-3 and ACPA levels. Study subjects were divided into two groups based on the difference between baseline and 24 months in case of MMP-3, baseline and 12 months in case of anti-CCP antibody levels. Subjects that showed any increase in 12 or 24 months compared to baseline were categorized into ‘elevated group’, and that showed any decrease in 12 or 24 months compared to baseline were categorized into ‘reduced group’. 21 patients of elevated MMP-3 group showed an increase in MMP-3 level from baseline (132.5 ± 87.9 ng/ml) to 24 months (207.9 ± 190.3 ng/ml), and 77 patients of reduced MMP-3 group showed a decrease in MMP-3 level from baseline (224.8 ± 205.6 ng/ml) to 24 months (74.8 ± 53.8 ng/ml). There were no significant differences in the baseline characteristic of these two groups (data not shown). DAS28-CRP outcomes were significantly better in patients with reduced than elevated MMP-3 levels, with 24-month DAS28-CRP remission rates of 54.5% and 15.0%, respectively (p < .01; Figure 5(A)).
Detection of synovial inflammation in rheumatic diseases using superb microvascular imaging: Comparison with conventional power Doppler imaging
Published in Modern Rheumatology, 2018
Kazuhiro Yokota, Takuma Tsuzuki Wada, Yuji Akiyama, Toshihide Mimura
In the present study, the total SMI score, but not the total cPDI score, was significantly correlated with the levels of serum CRP and MMP-3 (Figure 3). This suggests that the total SMI score reflects serum CRP and MMP-3 levels with more sensitivity than the total cPDI score. In general, synovial inflammation is a reflection of a systemic inflammatory reaction, which is demonstrated by significantly increased serum levels of CRP [12]. Therefore, the levels of serum CRP have been shown to mirror synovial inflammation and to correlate with radiographic progression [13]. On the other hand, MMP-3 is a proteolytic enzyme, which is produced by proliferating synovial tissues. The active form of MMP-3 is also a marker of synovial inflammation. A previous early RA cohort study reported that elevated levels of MMP-3 at baseline were significantly correlated with radiographic progression [14]. Taking this into consideration, SMI could be useful in evaluating the potential severity of synovial inflammation and facilitating prediction of radiographic progression in patients with RA.