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Therapeutic Approach in Fungal Keratitis
Published in Mahendra Rai, Marcelo Luís Occhiutto, Mycotic Keratitis, 2019
Victoria Díaz-Tome, María Teresa-Rodríguez Ares, Rubén Varela-Fernández, Rosario Touriño-Peralba, Miguel González-Barcia, Laura Martínez-Pérez, María Jesús Lamas, Francisco J. Otero-Espinar, Anxo Fernández-Ferreiro
Polyhexamethylene biguanide (PHMB), also known as polyhexanide, polyaminopropyl biguanide, polymeric biguanide hydrochloride or polyhexanide biguanide, is an antiseptic with antiviral and antibacterial properties used as an alternative for fungal keratitis treatment. It also shows a broad viricide and antifungal spectrum and has amoebicidal activity. Certainly, its antimicrobial efficacy has been demonstrated on Acanthamoeba polyphaga, A. castellanii, and A. hatchetti (Asiedu-Gyekye et al. 2015) by using 0.02 to 0.053% solutions without causing side effects.
Cosmetic Components Causing Contact Urticaria Syndrome: An Update
Published in Ana M. Giménez-Arnau, Howard I. Maibach, Contact Urticaria Syndrome, 2014
Another biguanide antimicrobial agent is polyhexanide or polyaminopropylbiguanide that may partly cross-react with chlorhexidine and that has shown to elicit IgE-mediated reactions from toilet paper [25] and wet wipes, as in a case we have diagnosed recently. This subject reacted positively on prick testing to the wipes and the antimicrobial agent and also had a positive basophil activation test; however, tests with chlorhexidine, another biguanide with which it may partially cross-react, remained negative. Polyhexanide is a poly-biguanide antiseptic, which is widely used, for example, in contact lens solutions, wound dressings, pool cleaners, and in cosmetics [25] (Figure 22.2).
Acute Rejection Following COVID-19 Vaccination in Penetrating Keratoplasty in a Young Male – A Case Report and Review of Literature
Published in Ocular Immunology and Inflammation, 2023
Elisa Marziali, Roberta Pasqualetti, Giacomo Bacci, Cinzia de Libero, Roberto Caputo
The patient had a corneal graft (18 months before) due to a severe Acanthamoeba keratitis. He was a contact lens wearer. The diagnosis was made based on the results of the laboratory testing (corneal and conjunctival swabs and lens liquid culture). The patient was treated with Polyaminopropyl Biguanide (PHMB) and Hexamidine di-isetionate 0.1% (Desomedine) eye drops 6 times daily while cyclopentolate eye drops was administered once per day for 3 months. After 3 months of therapy Desomedine and Ciclopentolate were stopped, while PHMB was tapered to 4 times a day for 1 month and then 3 times a day for another month. After 4 months from the infection, the clinical picture significantly improved, and the patient presented a corneal scar with no signs of inflammation.