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Piper longum (Long Pepper or Pipli) and Tinospora cordifolia (Giloy or Heart-Leaved Moonseed)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Yashashree Pradhan, Hina Alim, Nimisha Patel, Kamal Fatima Zahra, Belkıs Muca Yiğit, Johra Khan, Ahmad Ali
Methanolic extracts of giloy show increased cell death when tested on HeLa cells. It also reduces the effect of gamma radiation in Swiss albino mice and hence shows anticancer activity. Hexane extract of T. cordifolia inhibits the growth of tumor cells, whereas it enhances the expression of the proapoptotic BAX gene (Tiwari et al., 2018). It also reduces weight, occurrence, and carcinogenesis of papillary tumors. Palmatine (Figure 12.4i) and yangambin are the two compounds from giloy that help in the treatment of colon cancer ( Bala et al., 2015).
Medicinal Plants of Central Asia
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Farukh S. Sharopov, William N. Setzer
Berberis L. species (Berberidaceae). The Kyrgyz people take a decoction of the dried fruits of Berberis heterobotrys E.L. Wolf for fever (Soelberg and Jäger, 2016). In Tajikistan, the roots of Berberis integerrima Bunge (synonym Berberis oblonga (Regel) C.K. Schneid.) are used to treat wounds, bone fractures, rheumatism, radiculitis, heart pain, and stomach aches; a leaf decoction is used to treat kidney stones; an infusion of the flowers is used to treat tuberculosis, chest pains, and headaches; an infusion of the fruits is used to treat constipation and wounds (Zaurov et al., 2013). In Kyrgyzstan, a decoction of the roots and bark of B. integerrima is used to treat bone fractures (Pawera et al., 2016). The bark of Berberis vulgaris L. is used to treat skin conditions (wounds, skin irritations, allergic rashes, and dermatitis) (Mamedov et al., 2004). Isoquinoline alkaloids (berberine, palmatine, jatrorrhizine, berbamine, oxyacanthine = hydroxyacanthine, isocorydine, Figure 4.4) are found in the fruits, roots, and bark of Berberis spp. (Bhardwaj and Kaushik, 2012; Sharopov and Setzer, 2018).
Preclinical Antidepressant-Like Effects of Terpenes, Polyphenolics, and Other Non-Flavonoid Phytochemicals
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Palmatine is a protoberberine alkaloid found in several plants including Phellodendron amurense, Rhizoma coptidis, Coptis Chinensis and Corydalis yanhusuo.157 Palmatine has been found to exert MAO oxidase inhibition,158 as well as to enhance memory.159 It is an object of research for a variety of neuropsychiatric conditions.
Comparative proteomics analysis indicates that palmatine contributes to transepithelial migration by regulating cellular adhesion
Published in Pharmaceutical Biology, 2020
Wang Hui, Yang Feng, Yan Baoqi, Dong Shuwei, Xin Ruihua, He Jiongjie, Cui Dongan, Sun Yan, Zhang Shidong, Yan Zuoting
Palmatine, an isoquinoline alkaloid distributed in many botanical families, has been reported to possess multiple pharmaceutical and biological activities, involving its antibacterial (Chae et al. 1999), antiviral (Jia et al. 2010), gastroprotective (Wang et al. 2017) and anticolitis activities (Mai et al. 2019), and has been used in gastritis and peptic ulcer treatment (Zhou et al. 2017). Palmatine has also been shown to increase the effects of available antibiotics and decrease the emergence of multi-drug resistant (MDR) bacteria (Aghayan et al. 2017) and possesses promising therapeutic potential against cardiac hypertrophy (Yuan et al. 2017). Clinically, palmatine has been mainly used for the treatment of gastrointestinal tract infection, respiratory tract infection, urinary system infection, surgery-related infection, pelvic inflammation, chronic endometritis and gynaecological inflammation (Chao et al. 2009; Fang and Li 2016).