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Piper longum (Long Pepper or Pipli) and Tinospora cordifolia (Giloy or Heart-Leaved Moonseed)
Published in Azamal Husen, Herbs, Shrubs, and Trees of Potential Medicinal Benefits, 2022
Yashashree Pradhan, Hina Alim, Nimisha Patel, Kamal Fatima Zahra, Belkıs Muca Yiğit, Johra Khan, Ahmad Ali
Leaves and stems of T. cordifolia are used as therapeutic agents due to the presence of different classes of phytochemicals. These classes include alkaloids, steroids, diterpenoid lactones, glycosides, sesquiterpenoid, aliphatic compounds, essential oils, and lignans (Tripathi et al., 2015). Active compounds of T. cordifolia are shown in Figure 12.4.Major phytochemicals present in Tinospora cordifolia.
Lessons to Be Learnt from Ayurveda
Published in D. Suresh Kumar, Ayurveda in the New Millennium, 2020
Prachi Garodia, Sosmitha Girisa, Varsha Rana, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal
The actives from Tinospora cordifolia could enhance the host immune system by increasing immunoglobulins and white blood cell counts and stimulating stem cell proliferation, resulting in reduced solid tumors (Matthew and Kuttan 1999). Basella rubra, Musa paradisiaca, conch shell ash, Elaeocarpus tuberculatus, sulfur, potassium carbonate, Embelia ribes and Zingiber officinale are employed to treat arbuda neoplasms (Dash and Kashyap 1987). Pittaja arbuda tumors are cured with the leaves of Ficus glomerata, Tectona grandis and Elephantopus scaber, frequently followed by applying with honey, mixture of the fine pastes of Aglaia roxburghiana, Xanthium strumarium, Caesalpinia sappan, Terminalia arjuna and Symplocos racemosa (Dash and Kashyap 1987). An aqueous extract of Phyllanthus amarus administered in rats increased the life span of the animals and normalized the activity of γ-glutamyl transpeptidase (Rajeshkumar and Kuttan 2000).
Recent Insights on the Role of Natural Medicines in Immunostimulation
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
Isabella Muscari, Sabrina Adorisio, Trinh Thi Thuy, Tran Van Sung, Domenico V. Delfino
Tinospora cordifolia. This plant belongs to the Menispermaceae family and is used in Ayurvedic medicine as an immunostimulant. Studies demonstrate that an arabinogalactan polysaccharide (G1-4A) isolated from Tinospora cordifolia increased the differentiation of bone marrow-derived dendritic cells (BMDCs), leading to activation of cytotoxic T lymphocytes. Furthermore, BMDCs increased their killing capacity by releasing NO (Kaur et al. 2017).
Tinospora Cordifolia and Arabinogalactan in combination modulates benzo(a)pyrene-induced genotoxicity during lung carcinogenesis
Published in Drug and Chemical Toxicology, 2022
Yongli Chang, Diancui Zhang, Junxia Cui, Anshoo Malhotra
The membrane fluidity is crucial for normal homeostasis and has been observed to be influenced by phytochemicals or diet (Li et al.2021). Tinospora cordifolia (Tc) is a well-known medicinal plant with immunomodulatory and anticancer properties (Dou et al.2021). Moreover, Arabinogalactan has been reported recently, to possess good anti-cancer abilities against lung cancer (Pfeifer et al.2021). The genotoxic effects of carcinogens including BP have been reported earlier by exploring the formation of micronuclei in the lung cells. The induction of carcinogenesis often lead to increase in the formation of micronuclei confirming the state of mitotic catastrophe. This state is adopted by cells, when programmed cell death mechanism like apoptosis fails. Moreover, no specific study has been performed with regard to modulatory potential of Tinospora cordifolia and Arabinogalactan in combination against mitotic catastrophe, membrane stability parameters during cancer. Therefore, the present study is dedicated to investigate the prophylactic action of this combination of Tinospora cordifolia and Arabinogalactan in modulating mitotic catastrophe and key surface membrane changes during lung cancer.
28-day repeated dose toxicological evaluation of Coronil in Sprague Dawley rats: Behavioral, hematological, biochemical and histopathological assessments under GLP compliance
Published in Drug and Chemical Toxicology, 2023
Acharya Balkrishna, Sandeep Sinha, Anurag Varshney
The principal component of Coronil is the stem extract of Tinospora cordifolia. With regard its safety evaluation, the aqueous extract of Tinospora cordifolia has been reported to be non-toxic up to a dose of 2000 mg/kg in an acute toxicity evaluation in Wistar rats (Ghatpande et al. 2019). In an alternative acute toxicity assessment, no remarkable adverse effect and no mortality was reported in rats that were orally administered a dose of 3000 mg/kg Tinospora cordifolia extract (Agarwal et al. 2002). Further, in one sub-acute toxicity assessment a Siddha formulation, made from the stem of Tinospora cordifolia, using a traditional method, was administered to Wistar rats of either sex at the doses of 360, 1800 and 3600 mg/kg/day for 28 days (Uma et al. 2016). This study concluded that the preparation was devoid of any major toxic effects up to the highest dose, which was nearly ten times of the intended therapeutic dose. Additionally, in another study (Sharma et al. 2011) a hydro-alcoholic extract of the stem bark of the herb was administered to female albino rats at the doses of 250, 500 and 1000 mg/kg/day for three weeks, wherein, the extract did not demonstrate any untoward effect, except some observational effects like initial excitement, followed by mild depression, dullness, decreased respiration and reduced spontaneous motor activity only at the high dose. Based on its proportion in Coronil, the daily doses of the extract of Tinospora cordifolia, which the animals would have received in our study is calculated to be approximately 47, 141 and 470 mg/kg/day respectively and even the highest dose administered to the animals is a fraction of the dose received by the animals in the above mentioned sub-acute toxicity studies.
The potential of ODFs as carriers for drugs/vaccines against COVID-19
Published in Drug Development and Industrial Pharmacy, 2021
Maram Suresh Gupta, Tegginamath Pramod Kumar
A decoction of various Ayurvedic herbs namely: ‘Tinospora cordifolia, Zingiber officinale, Curcuma longa, Ocimum sanctum, Glycyrrhiza glabra, Adhatoda vasica, Andrographis paniculata, Swertia chirayita, Moringa oleifera, Triphala and Trikatu’ have broad antiviral activity and protease inhibitor activity [88–90]. This decoction could be very useful in COVID-19 patients who are quarantined.