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Botanicals and the Gut Microbiome
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Coptis chinensis is traditionally used in traditional Chinese Mmedicine and contains berberine, an isoquinoline alkaloid, which has shown an effect with non-alcoholic fatty liver disease (NAFLD), through the increase in the abundance of bacteria associated with metabolic improvements such as those from Bacteroidetes, Bifidobacterium and Lactobacillus (Cao et al., 2016).
Antihypertensive effects of oriental drugs in human and SHR
Published in H. Saito, Y. Yamori, M. Minami, S.H. Parvez, New Advances in SHR Research –, 2020
Hideaki Higashino, Aritomo Suzuki, Koichiro Komai
Coptis chinensis Franch. (ref.A, 1990; ref.9, 1963). A major component of this plant, berberin, decreased blood pressures in anesthetized dogs, cats and rabbits, and also in conscious rats given intravenously or orally. At common or lower doses, an excitation of the heart and an increment of coronary arterial blood flow were observed, but at higher doses heart function was inhibited on the contrary. Although there were many reports related to the antihypertensive effects, both actions of direct vasodilative effect and potentiation on acetylcholine mediated hypotensive effect were generally accepted as its vasodepressant mechanism.
Role of Herbal Medicines During Pregnancy and Labor
Published in Megh R. Goyal, Hafiz Ansar Rasul Suleria, Ademola Olabode Ayeleso, T. Jesse Joel, Sujogya Kumar Panda, The Therapeutic Properties of Medicinal Plants, 2019
Fanuel Lampiao, Ibrahim Chikowe, Mayeso Gwedela, Kondwani Katundu
Lin-Yan Li et al., [28] assessed the embryotoxicity of four commonly used Chinese herbs in China during pregnancy: Rhizoma Atractylodes macrocephala, Radix isatidis, Coptis chinensis, and Flos Genkwa. The herbs were studied using embryonic stem cell test (EST) and prediction models based on concentrations of compounds inhibiting the proliferation of 50% embryonic stem cells (ESCs; IC50ES), concentrations inhibiting 50% of 3T3 cells (IC503T3) and concentrations inhibiting differentiation of 50% ESCs (IC50ES). Rhizoma Atractylodes macrocephala and Radix Isatidis did not show embryotoxicity, while Coptischinensis and Flos Genkwa showed weak embryotoxicity and strong embryotoxicity, respectively [28].
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study
Published in Xenobiotica, 2023
Si-cong Li, Min Zhang, Bin Wang, Xu-ting Li, Ge Liang
A cohort of 12 healthy rats was allocated randomly to two groups, namely, the control group (CTR) and the COP group (n = 6 rats per group). The dosing regimen for the COP group was determined based on the oral dose of Coptis chinensis specified for rabbits in the Veterinary Pharmacopoeia of the People’s Republic of China (2020 edition) (Chinese Veterinary Pharmacopoeia Committee 2020), the concentration of COP in Coptis chinensis, and the conversion of oral dose for rabbits to rats. Specifically, a final dose of 50 mg/kg of COP was administered intragastrically to the rats in the COP group for 7 consecutive days. In contrast, the rats in the CTR group received an equal volume of sterile water by the same route of administration. It should be noted that the COP was mixed with sterile water to make a suspension before each gavage.
Jateorhizine alleviates insulin resistance by promoting adipolysis and glucose uptake in adipocytes
Published in Journal of Receptors and Signal Transduction, 2021
Changqin Cheng, Zhiyong Li, Min Zhang, Dezhi Chen
In the traditional cognition of Chinese medicine, IR patients often present with the syndrome of interior dampness-heat in Chinese medical practice, while the cold property of coptis chinensis can remove the dampness and heat, so coptis chinensis may have a potential therapeutic effect in the treatment of IR [7]. In recent years, traditional Chinese medicine studies have found that coptis chinensis is the most commonly used compound compatibility drug for lowering glucose [8–10]. Coptis chinensis is a perennial herbaceous plant of ranunculaceae, its rhizome has the effect of lowering blood glucose and regulating blood lipid [11], which is mainly related to the pharmacoactive ingredients in the rhizome, including berberine, palmatine, coptisine and so on [12]. Among them, berberine is the most studied rhizoma coptis alkaloid, which has the effect of improving atherosclerosis [13]. Jateorhizine (Jat) is a homologen of berberine, which is also a tetrahydroisoquinoline alkaloid with the similar chemical structure to berberine. Animal experiments have shown that Jat can lower blood glucose level in diabetic mice [14,15]. However, there are few studies on the role of Jat in IR, and the specific mechanism of its hypoglycemic effect is still ambiguous.
Characterization of hydrocoptisonine metabolites in human liver microsomes using a high-resolution quadrupole-orbitrap mass spectrometer
Published in Xenobiotica, 2020
Su Min Choi, Younah Kim, Jaeick Lee, Ju-Hyun Kim, Taeho Lee, Byung Sun Min, Jeong Ah Kim, Sangkyu Lee
Coptis chinensis belongs to the Ranunculaceae family and is one of the most widely used traditional Chinese medicines. It has attracted much attention because of its multiple pharmacological effects, such as anti-antiviral, anti-inflammatory, and anti-microbial activities, and its ability to dry dampness, treat toxicosis, and detoxify (Commission CP, 2015; Hwang et al., 2006; Lee et al., 2018; Miao et al., 2015; Yu et al., 2005). Hydrocoptisonine is a new protoberberine-type compound isolated from the rhizomes of C. chinensis by our group, previously (Cao et al., 2018) (Figure 1). Although there is no data directly reporting the pharmacological effects of hydrocoptisonine itself, as a newly identified compound, its pharmacological activity will be determined in the future.