China
Africa
Explore chapters and articles related to this topic
Case 77
Published in Simon Lloyd, Manohar Bance, Jayesh Doshi, ENT Medicine and Surgery, 2018
Simon Lloyd, Manohar Bance, Jayesh Doshi
Salicylate desensitisation in Samter's triad patients. This can be performed by the oral route (using aspirin) or by the nasal route (using lysine-acetylsalicylate douching). There is good evidence for the oral route but less for nasal desensitisation.
Headache
Published in Peter R Wilson, Paul J Watson, Jennifer A Haythornthwaite, Troels S Jensen, Clinical Pain Management, 2008
Peer Tfelt-Hansen, Rigmor Jensen
How do the triptans compare with other drugs for acute migraine treatment? As shown in Table 34.4, sumatriptan (100 mg), eletriptan (40 and 80 mg), almotriptan (12.5 mg), and rizatriptan (10 mg) were superior to oral ergotamine plus caffeine (2 mg+200 mg).62[II] Oral sumatriptan (100 mg) was not superior to aspirin with metoclopramide for the first treated attack (but superior for the second and third attacks),62[II] and was comparable to lysine acetylsalicylate plus metoclopramide (1620 mg (~900 mg aspirin) +10 mg).81[II] Sumatriptan (50 mg) was equivalent to effervescent aspirin (1000 mg) in two trials.82, 83[II] Sumatriptan was superior to tolfenamic acid rapid release in a randomized clinical trial, 75 versus 58 percent.69 Rectal sumatriptan (25 mg) was inferior to rectal ergotamine plus caffeine (2 mg+ 200 mg), but caused fewer adverse events (8 versus 27 percent).62[II] In four out of five RCTs where a triptan and an ergot alkaloid were compared, there were less recurrences after the ergot alkaloid than after the triptan.62, 67[II]
Routes of administration
Published in Pamela E Macintyre, Suellen M Walker, David J Rowbotham, Clinical Pain Management, 2008
Numerous animal studies attest to the efficacy of intrathecally administered NSAIDs. However, only one case series has shown that an intrathecally administered NSAID (lysine acetylsalicylate) can relieve intractable pain in humans.142[III] So far, no clinical trials have been conducted.
Exploring the drug-induced anemia signals in children using electronic medical records
Published in Expert Opinion on Drug Safety, 2019
Duan-Fang Fan, Yun-Cui Yu, Xuan-sheng Ding, Xiao-Lu Nie, Ran Wei, Xin-Ying Feng, Xiao-Xia Peng, Miao-Miao Gao, Lu-Lu Jia, Xiao-Ling Wang
Finally, the remaining four associations (with sulfamethoxazole, lysine acetylsalicylate, paracetamol, and ceftriaxone) were previously known in the context of anemia. Sulfamethoxazole is indicated for the treatment of skin and urinary and respiratory tract infections caused by methicillin‐resistant Staphylococcus aureus. Treatment with sulfamethoxazole was found to aggravate the hemolysis of patients with the variants of glucose-6-phosphate dehydrogenase [32], and also caused megaloblastic anemia [33,34]. Lysine acetylsalicylate and paracetamol are non-steroidal anti-inflammatory drugs that can cause gastrointestinal bleeding and anemia [35,36]. Lysine acetylsalicylate is a complex salt of lysine and acetylsalicylate that is used for the treatment of fever and mild to moderate pain. Acetylsalicylate has been reported to cause anemia [37,38], and paracetamol may cause hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency [39,40]. Ceftriaxone may induce hemolytic anemia in children, which would be severe and could be fatal. Once anemia is suspected to be caused by the drug, ceftriaxone treatment should be discontinued even if the symptoms appeared to be mild. The application of the two-step method suggests that this method leads to reliable results.
Pharmacological strategies to treat attacks of episodic migraine in adults
Published in Expert Opinion on Pharmacotherapy, 2021
Oral triptans (100 mg sumatriptan [74], 10 mg rizatriptan [75], and 40 mg eletriptan [76]) were superior to 2 mg oral ergotamine +100 mg caffeine, whereas 2 mg rectal ergotamine +200 mg caffeine (73% HR at 2 h) was superior to 20 mg rectal sumatriptan (HR 63% at 2 h) [16]. Sumatriptan (100 mg) was superior to a drug combination with 1 g acetaminophen [73]. Sumatriptan nasal spray (20 mg) was superior to dihydroergotamine (DHE) nasal spray (2 mg) [16], whereas subcutaneous sumatriptan (6 mg) was superior to subcutaneous DHE at 1 h and 2 h, but after 3 h and 4 h, the two drugs were equipotent [77]. Finally, intravenous lysine acetylsalicylate was inferior to subcutaneous sumatriptan [78].