China
Africa
Explore chapters and articles related to this topic
Cold Sores/Herpes Simplex/Herpes Labialis
Published in Charles Theisler, Adjuvant Medical Care, 2023
L-lysine at least 1,000–1,248 mg (four 312 mg tablets) per day for six months, was found to reduce the frequency of outbreaks.3 In a separate study, lysine appeared to reduce the frequency, duration, and severity of outbreaks.4 Overall, lysine’s efficacy for herpes labialis may lie more in prevention than treatment.5
Depression, Anxiety, Stress, and Spirituality in Cardiovascular Disease
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
Erminia Guarneri, Shyamia Stone
L-Lysine and L-arginine are additional amino acids that serve to impact stress and anxiety. L-Lysine has been shown to act as a partial serotonin receptor 4 antagonist, and a partial benzodiazepine agonist.132 While there is not much research available for the use of L-lysine as a monotherapy, when L-lysine is used in combination with L-arginine, they reduce subjective trait and stress-induced state anxiety, as well as levels of stress hormones such as cortisol.132,119
Single Amino Acids
Published in Luke R. Bucci, Nutrition Applied to Injury Rehabilitation and Sports Medicine, 2020
A final finding on amino acids and connective tissue healing is concerned with l-lysine. A recent study verified the ability of l-lysine supplements (400 to 800 mg/d) to significantly enhance the intestinal absorption of calcium (from 3.0 g of calcium chloride) in 74 osteoporotic women.402 In addition, lysine supplementation blunted the urinary excretion of calcium normally seen after a calcium load. Thus, ingestion of 400 to 800 mg of l-lysine along with a calcium supplement can positively affect calcium balance, with important implications for prevention and treatment of bone loss disorders.
Effect of Oyster Meat Preload on Postmeal Glycemic Control in Healthy Young Adults
Published in Journal of the American College of Nutrition, 2020
Shuting Lin, Gengxin Hao, Dong Lai, Yan Tian, Min Long, Fei Lai, Yongmei Xiong, Changfu Ji, Yuan Zang
In addition to proteins, amino acids have also received great attention. Numerous amino acids are closely related with insulin secretion (26). OM is also rich in amino acids with glutamic acid content as the highest, followed by aspartic acid and glycine. Although the role of glutamate in insulin secretion is still controversial, glutamate is an important precursor for the synthesis of several amino acids, such as glutamine, arginine, and lysine, which regulate blood glucose (27). Greenfield et al. (28) reported that glutamine can stimulate the secretion of GLP-1 in healthy and diabetic patients. Arginine supplementation can improve vascular insulin sensitivity (5). Lysine exhibits a modest lowering effect on blood glucose and insulin responses (29). Glycine can promote the utilization of blood glucose in tissues and reduces blood glucose (30). Some plants with hypoglycemic activity exhibit similar amino acid composition (31). Amino acids can regulate islet function and improve insulin resistance through mTOR-S6k1 signaling pathway. Further experiments are needed to verify the mechanism (32, 33).
Pharmacological treatment strategies for subependymal giant cell astrocytoma (SEGA)
Published in Expert Opinion on Pharmacotherapy, 2020
Daniel Ebrahimi-Fakhari, David Neal Franz
Mouth sores or aphthous ulcers are the most frequently encountered side effects, occurring in 70–80% of patients. Anticipatory guidance plays a large role in managing mouth sores. The patient should be advised to maintain good oral hygiene while on mTOR inhibitors. A variety of interventions can decrease the incidence of mouth sores, such as lysine supplementation, taking the medication with food, e.g. in pudding or other soft food. Dexamethasone 0.1 mg/mL oral rinse can be used daily as a prophylactic agent, and 3–4 times daily if at these ulcers occur. At these ulcers occurring in the anterior aspect of the mouth or about the lips can be managed with triamcinolone in oral paste. Other mouth rinses such as sucralfate or mixtures of equal amounts of diphenhydramine, liquid antacid, and viscous lidocaine can be useful. mTOR inhibitors can impair wound healing so we recommend them being held for 1 week prior to any elective surgery until any surgical wound is well healed. In the event of unexpected surgery, they are again held until wounds are clinically well healed. Minor procedures such as restorative dental work or suture of lacerations typically do not require interruption of therapy. Because of their immunosuppressant effects we recommend that mTOR inhibitors be held during times a significant illness such as with temperature elevations greater than 38.3 Celsius (101 Fahrenheit), clinical pneumonia, or gastroenteritis with dehydration. Nonspecific upper respiratory symptoms in the absence of significant fever do not necessarily require therapy interruption.
An engineered human IgG1 CH2 domain with decreased aggregation and nonspecific binding
Published in mAbs, 2020
Guangcan Cao, Xinyu Gao, Yancheng Zhan, Qingguang Wang, Zhe Zhang, Dimiter S. Dimitrov, Rui Gong
As a basic amino acid, lysine has been widely used in protein engineering to reduce aggregation. To decrease APR2 in m01s5, lysine scanning was performed to mutate the residues one by one in this region (Figure S2a). After scanning, only one mutant (m01s5.4) with the replacement of N276 by lysine still maintained a good soluble expression level (Figure S2b). TANGO analysis showed that the APR2 in m01s5.4 was significantly reduced compared to that in m01s5 (Figure 2b vs. Figure 2a). Sequence alignment of m01s, m01s5, and m01s5.4 was also performed (Figure 2c). It could be observed that many hydrophobic residues in APRs in m01s were replaced by hydrophilic or charged amino acids, whereas the original hydrophilic residue T260 in APR1 and the basic residue R301 in APR3 were either unchanged or changed to hydrophilic serine, respectively (Figure 2c). The soluble expression levels of m01s and m01s5.4 were compared side by side at 30°C and 37°C. In general, both of them could be expressed at comparable levels (Figure 2d). m01s5.4 was subjected to further characterization.