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Premalignant Neoplasms
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Definition: Actinic cheilitis (AC) is a UV-radiation induced premalignant lesion of the vermil-lion border of the lip. Clinically similar to AKs, AC is characterized by atrophy, dryness, and an obscured indistinct border.
Lasers in Photomedicine
Published in Henry W. Lim, Nicholas A. Soter, Clinical Photomedicine, 2018
Roy G. Geronemus, Robin Ashinoff
Use of the carbon dioxide laser for the treatment of actinic cheilitis has been particularly successful (60). This approach results in significant success with minimal morbidity compared with other therapeutic approaches. The laser vaporizes abnormal tissue at very low power densities and healing takes place within 2 or 3 weeks.
Premalignant lesions
Published in Richard P. Usatine, Daniel L. Stulberg, Graham B. Colver, Cutaneous Cryosurgery, 2014
Richard P. Usatine, Daniel L. Stulberg, Graham B. Colver
Intense and prolonged exposure to ultraviolet light may lead to changes on the lower lip (Figure 9.18). This begins with dryness and then thickened white plaques start to develop. Variable inflammation and crusting follow. Actinic cheilitis should be differentiated from SCC, lichen planus, contact dermatitis, and lupus erythematosus. If the clinical picture is not clearly actinic cheilitis, then a shave biopsy should be performed.
Oral Potentially Malignant Disorders (OPMD): What is the clinical utility of dysplasia grade?
Published in Expert Review of Molecular Diagnostics, 2021
Kenneth P. H. Pritzker, Mark R. Darling, Jason T-K Hwang, David Mock
A third approach has been to identify specific OPMDs that have an elevated risk of malignant transformation irrespective of whether OED is present [25]. As the risk elevation in some OPMDs is quite small, this approach by itself does not provide risk prediction for the individual patient and therefore may be of limited clinical utility. Accordingly, this approach is often supplemented by study of associated molecular markers [78]. Actinic cheilitis and OLLs are examples of two distinctive OPMDs which have been extensively studied as markers of malignant transformation. Actinic cheilitis is a common disorder in countries such as Spain [140] and Brazil [141] among farmers and other individuals exposed to prolonged ultraviolet solar radiation. Epithelial dysplasia of various grades is a common characteristic feature of actinic cheilitis at biopsy irrespective of whether traditional WHO or binary grading systems are used [142–144]. Malignant transformation rates have not been well studied, but on systematic review, are considered to be about 3%, a transformation rate much lower than individuals with oral cavity dysplastic lesions [145]. Further, there is no correlation between the degree of dysplasia or mutant p53 expression in the epithelium immediately adjacent to invasive OSCC arising in actinic cheilitis [146]. A comprehensive meta-analysis of immunohistochemical markers included studies of 41 different proteins in actinic cheilitis and failed to show differential effects of the protein markers with dysplasia grade [147].
Occupational variation in the incidence of lip cancer in the Nordic countries
Published in Acta Oncologica, 2023
Rayan Mroueh, Timo Carpén, Antti Mäkitie, Johnni Hansen, Sanna Heikkinen, Elsebeth Lynge, Jan Ivar Martinsen, Jenny Selander, Ingrid Sivesind Mehlum, Jóhanna Eyrún Torfadottir, Tuula Salo, Eero Pukkala
In our study, the highest RR of lip cancer was observed in fishermen (SIR 2.26, 95% CI: 2.04–2.50). Spitzer et al. [9] described almost 50 years ago a significant age-adjusted RR of 1.65 for lip cancer in Newfoundlander fishermen as compared to the general population. Actinic cheilitis, also known as ‘sailor’s lip’, is a well-known premalignant lesion of the lip, associated with chronic sunlight exposure, and is frequently diagnosed in fishermen [18]. Indeed, a Brazilian study [19] reported a prevalence of 11%, and a Chilean study [20] a prevalence of 43% of actinic cheilitis among fishermen. Concerning the general population, a Brazilian multicenter study [21] reported a 1% rate of actinic cheilitis in lip biopsy specimens submitted for examination.
Ingenol mebutate treatment for actinic cheilitis: clinical, histopathological and p53 profile of 14 cases
Published in Journal of Dermatological Treatment, 2021
Rita de Cassia Rossini, Gerson Dellatorre, Lismary Aparecida de Forville Mesquita, Roberto Gomes Tarlé
Actinic cheilitis (AC) is a chronic condition of the lip, considered a potentially malignant condition that represents incipient squamous cell carcinoma (SCC) in situ, similarly to actinic keratosis (1,2). AC predominantly affects the lower lip of light-skinned men over 40 years of age chronically exposed to ultraviolet light (1,3,4).