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Cheilitis/Angular Cheilitis
Published in Charles Theisler, Adjuvant Medical Care, 2023
Erythema (redness), painful cracking, scaling, bleeding, and ulceration at the corners of the mouth (labial commissures) is known as angular cheilitis. Cheilitis can be a presenting sign of nutritional deficiency of iron, riboflavin (B2), folate (B9), cobalamin (B12), or zinc. Treatment is toward the underlying cause.1
Mouth, tongue, lips and ears
Published in Richard Ashton, Barbara Leppard, Differential Diagnosis in Dermatology, 2021
Richard Ashton, Barbara Leppard
Cheilitis means inflammation of the lips, and in angular cheilitis only the corners of the lips are involved. It occurs in individuals who wear dentures, and is usually due to infection with Candida albicans from under the top denture. Poorly fitting dentures may also lead to overlap of the lower by the upper lip resulting in angular cheilitis. It can also be due to an irritant dermatitis from saliva leaking from the sides of the mouth, by lip licking, or infection due to staphylococci causing a localised impetigo.
Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Sixteen patients had allergic contact dermatitis from Myroxylon pereirae resin in topical pharmaceutical preparations (2). Eight patients had allergic contact cheilitis from MP in ‘Dermophil Indien’, a lip balm (40).
Lichenoid lesions of the upper labial mucosa: a systematic review and a report of a new case with extensive follow-up
Published in Acta Odontologica Scandinavica, 2023
Lesions with lichenoid and granulomatous histopathological features have been described in the literature before. Ferguson et al. [23] reported a patient with OLP and concomitant granulomatous cheilitis. Studying lichenoid and granulomatous dermatitis (LGD), Magro and Crowson [24], Breza and Magro [25], and Braswell et al. [26] found perineural inflammation in some LGD cases [25,26], especially associated with non-drug-induced hypersensitivity (reaction to tattoos and post-herpetic dermatitis) [26]. Most lesions in our review were found to show perineural inflammation, and the patients experienced pain or discomfort at their location. Since immune-cell infiltration may be implicated in post-herpetic neuralgia [27], a similar mechanism might explain the sometimes significant pain associated with upper-lip lichenoid lesions.
Oral isotretinoin for acne: a complete overview
Published in Expert Opinion on Drug Safety, 2022
Alessia Villani, Francesca Nastro, Francesca Di Vico, Gabriella Fabbrocini, Maria Carmela Annunziata, Lucia Genco
Dryness and desquamation of the skin and mucous membranes are common side effects: above all, cheilitis (90–100% of individuals) is the most common mucocutaneous adverse event [53]. They develop as a result of a pharmacologically induced sebum-suppressive effect [54], thickness of stratum corneum and alteration of cutaneous barrier [55,56], which cause xerotic and desquamative alterations; these adverse events mainly involve sites with a high concentration of sebaceous glands such as face, chest, and back. They are reversible, dose-dependent, predictable, and manageable. The absence of these reactions raises the possibility of underdosing [57]. On the contrary, when patients are given a dose that is too high for them, they may experience dryness of nose and eyes. Another uncommon reaction that can occur when the dose of isotretinoin is too high is acne fulminans [58]. Other severe skin reactions (e.g. Stevens–Johnson syndrome, erythema multiforme, and toxic epidermal necrolysis) have only been observed in few occasions [59].
Topical tacrolimus with different frequency for exfoliative cheilitis: a pilot study
Published in Journal of Dermatological Treatment, 2022
Qian-Qian Zhang, Pan Xu, Chen Sun, Li-Jun Liu, Wei-Wen Jiang
Exfoliative cheilitis (EC) is a common inflammatory disease affecting upper or lower of lip characterized by dryness, persistent repeated production and desquamation of scales, sometimes followed by cracking and bleeding. Some patients report burning, sensation, and itching (1–4). Etiology of it is still unknown, although psychiatric condition, bacterial/fungal infection, season changes, vitamin deficiency, and factitious activity may contribute to the occurrence (4–9). EC is also the oral manifestation of certain systemic diseases, such as HIV infection, somatoform autonomic dysfunction (1,10). A number of treatments have been applied in the patients with EC, including corticosteroids, glycerin borax, laser therapy, anti-fungal drugs, hyaluronidase, herbal, and anti-depressant medicine (2,4,11–13). However, there are no definitive recommendations for the management of EC.