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Cancer
Published in Jahangir Moini, Matthew Adams, Anthony LoGalbo, Complications of Diabetes Mellitus, 2022
Jahangir Moini, Matthew Adams, Anthony LoGalbo
Cancer of the urinary bladder is also called transitional cell carcinoma. It is the most common malignancy of the urinary tract, characterized by multiple growth that tends to recur in a more aggressive form. The majority of bladder malignancies are transitional cell carcinomas and a small percentage are squamous cell carcinomas or adenocarcinomas. The adenocarcinomas may occur as primary tumors, or in rare cases as metastatic tumors from an intestinal carcinoma. They may develop from intestinal metaplasia of the urothelium. Increased incidence of bladder cancer has been linked to type 2 diabetes.
Lynch Syndrome
Published in Dongyou Liu, Handbook of Tumor Syndromes, 2020
Andreas V. Hadjinicolaou, Mashiko Setshedi
For transitional cell carcinoma of the upper urinary tract (ureters and renal pelvis), general lifetime risk is 4%–10%. Certain groups of LS patients (e.g., those with MSH2 mutations) are at an increased risk not only for upper urinary tract tumors but also bladder cancer. Lifetime risk for development of small bowel adenocarcinoma in LS patients is 1%–3%, significantly higher than the estimated 0.3% for the general population. Small intestinal tumors in LS mainly occur in the duodenum and jejunum.
Neoplasia
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
Transitional cell carcinoma arises from the transitional epithelium of the urogenital tract. It too may show considerable variation in appearance: well-differentiated papillary transitional cell carcinomas resemble papillomas, and may not show any invasion of the underlying stroma, but they are regarded as malignant for practical purposes because they have a high risk of recurrence, often in a more aggressive form. Poorly differentiated transitional cell carcinomas have a more solid architecture and frequently invade deeply within the wall of the bladder or ureter.
Association of Recommended and Non-Recommended Food Score and Risk of Bladder Cancer: A Case-Control Study
Published in Nutrition and Cancer, 2022
Melika Hajjar, Arezoo Rezazadeh, Farah Naja, Mehdi Kardoust Parizi, Reza Alaghehbandan, Marzie Pourkerman, Bahram Rashidkhani
This is a hospital-based case-control study conducted at three referral hospitals in Tehran (the capital of Iran), between December 2018 and March 2020. Cases consisted of 103 patients aged more than 45 years, who were newly diagnosed (<6 mo,) with BC (transitional cell carcinoma). Of the cases, 63% had noninvasive (NMIBC, Ta/T1) cancers and 37% were muscle-invasive (MIBC, other T). All cases were confirmed histologically using tumor tissue specimens taken during surgery or from biopsy. Cases were excluded if they had a history of other types of cancer, have undergone chemotherapy or radiotherapy, or were following any specific type of diet. The control group consisted of 200 patients of similar age to cases, from the same hospitals, with a wide spectrum of non-neoplastic diseases unrelated to smoking, and long term diet modification (eg., trauma, orthopedic conditions, disk disorders, acute surgical conditions and eye, nose, ear or skin disorders). Controls were not recruited in this study if they had a neoplastic disease that is related to smoking and long-term diet modification. All patients in both groups were interviewed during hospital admission. New BC patients were interviewed on the admission day while previously discharged BC patients were interviewed when they came for follow up visits. The same procedure was used for the interviews of controls.
A retrospective study of the epidemiology and histological subtypes of ovarian epithelial neoplasms at Charlotte Maxeke Johannesburg Academic Hospital
Published in Southern African Journal of Gynaecological Oncology, 2021
The peak incidence of malignant tumours in our study occurred between 41 and 60 years of age, which is similar to findings by Mondal et al.26 The majority of malignant tumours in the current study demonstrated serous morphology (specifically HGSC), followed by MC, CCC and EC respectively. Transitional cell carcinoma was not identified in this cohort. A meta-analysis of the global literature between 2003 and 2012 showed that South Africa had the third highest median value of relative frequencies out of 17 countries, for both LGSC and HGSC combined.37 This mirrors findings in the present study in which SC, particularly HGSC, was the most frequent malignant neoplasm followed closely by LGSC. Piszczan et al., however, showed that adenocarcinoma not otherwise specified was the most common histological subtype.38
The Effect of Daily Fluid Management and Beverages Consumption on the Risk of Bladder Cancer: A Meta-analysis of Observational Study
Published in Nutrition and Cancer, 2018
Xuwei Hong, Qingchun Xu, Kaijian Lan, Hong Huang, Yuanfeng Zhang, Shaochuan Chen, Zepai Chi, Jiahua Lin, Yizhou Zhou, Weichu Wu, Guoyuan Liu, Weiqiang Lin, Yonghai Zhang
Our meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines (8). A systematic literature search was performed in Pubmed, Embase and the Cochrane Library to identify relevant studies of the association between daily fluid intake and risk of bladder cancer from inception to June 2018. For exposure of interest, databases were searched using the following terms: fluid, or liquid*, or water, or beverage*, or drink*, or alcohol, or wine, or beer, or coffee, or tea, or milk, or juice*, or soda, or diet*. For outcome of interest, search terms included: bladder cancer, or transitional cell carcinoma, or bladder tumor, or urinary bladder neoplasms. Our search was focused on human studies. No more additional filters were restricted in our search strategy. Furthermore, we also performed a manual search for reference lists of relevant review articles to identify all available studies.