China
Africa
Explore chapters and articles related to this topic
Cancer of the Nasopharynx in Man: Younger Age Peak and Related Aspects
Published in D. V. M. Gerd Reznik, Sherman F. Stinson, Nasal Tumors in Animals and Man, 2017
V. Balakrishnan, P. Gangadharan
The relatively higher incidence of lymphoepithelioma in a region of genetically closer people suggests the existence of a genetic mechanism in this case also. Moreover, the two peaks for lymphoepithelioma, one during the maturation period and the other in late middle age, strongly suggest that endocrine factors may be playing a role in the development of this disease. This has been suggested by both Cammoun et al.49 and Parikh and El-Gham-rawi.52 In this connection, it is interesting to note the existence of another tumor, nasopharyngeal angiofibroma, which almost always originates in the nasopharynx. Though benign, it shows relentless growth and destructiveness. While exceptions do occur, the disease is mostly confined to juvenile, adolescent, and young adult males and tends to regress in maturity. These factors have led several authors to believe that the disease is hormonally influenced. Though hormonal studies on nasopharyngeal patients have not so far produced conclusive favorable evidence, this might at least partly be due to the mixing up of histological types.
Canine and Feline Nasal and Paranasal Neoplasm: Morphology and Origin
Published in Gerd Reznik, Sherman F. Stinson, Nasal Tumors in Animals and Man, 2017
Although the cell of origin of nonkeratinizing squamous cell carcinoma, transitional carcinoma, and lymphoepithelioma have been determined ultrastructurally to be squamous cells, their histologic classification is still a subject of considerable controversy in the human literature. Transitional carcinoma and lymphoepithelioma classifications still persist because of their long usage rather than their cell of origin or distinct biologic behavior.52,53,56,64 In veterinary literature, these terms are not in general use. For the present classification, we have grouped these three types under “nonkeratinizing squamous cell carcinoma” and consider them variants of the same neoplasm.
Epstein-Barr Virus and Nasopharyngeal Carcinoma
Published in D. V. M. Gerd Reznik, Sherman F. Stinson, Nasal Tumors in Animals and Man, 2017
Lee S. Tuckwiller, Ronald Glaser
The presence of high levels of anti-EBV antibody is of some prognostic significance in that successfully treated patients show a gradual decline in antibody titers to normal levels,70,73 and recurrence of disease often results in an increase in VCA and EA antibody titers which may precede the appearance of clinical symptoms, i.e., recurrence of the primary tumor or a metastatic tumor mass. An example of this antibody pattern is shown in Figure 4, which shows EBV antibody titers in a long-term study in a female NPC patient (NPC-3).73 The tumor was classified as a lymphoepithelioma and was positive for EBV DNA (Figure 5).
The clinicopathological significance and predictive value for immunotherapy of programmed death ligand-1 expression in Epstein-Barr virus-associated gastric cancer
Published in OncoImmunology, 2021
Xiao-Li Wei, Qian-Wen Liu, Fu-Rong Liu, Sha-Sha Yuan, Xiao-Fen Li, Jia-Ning Li, An-Li Yang, Yi-Hong Ling
Interestingly, PD-L1 expression was significantly associated with lymphoepithelioma-like GC in patients with EBVaGC (Tables 2). In lymhoepithelioma-like GC, 69.2% of patients were PD-L1 positive, while only 32.1% of patients were PD-L1 positive in non-lymhoepithelioma-like GC. Thus that lymhoepithelioma-like GC may be an important subtype of EBVaGC which deserves further research in the area of immunotherapy. We further analyzed the clinicopathological and prognostic association of lymhoepithelioma-like GC in our 159 patients diagnosed with EBVaGC. Lymhoepithelioma-like GC was significantly correlated with smaller tumor size (P < .001), less advanced T category (P = .003), less advanced N category (P < .001), less frequent distant metastasis (P < .001), less advanced TNM classification (P < .001), less frequent nervous invasion (P = .01), and less frequent venous invasion (P = .001) (Supplementary Table 4S). A significantly superior disease-free survival (DFS) and OS were also found in lymhoepithelioma-like GC subtype compared with non-lymhoepithelioma-like GC subtype in EBVaGC patients (Supplementary Figure 3S).
Upper urinary tract urothelial carcinoma and its variants: transition from morphology to personalized molecular characterization in diagnosis, prognosis, and therapy
Published in Expert Review of Molecular Diagnostics, 2018
Alessia Cimadamore, Marina Scarpelli, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi
This variant, very rare in the upper urinary tract, shows a dense chronic inflammatory infiltrate surrounding islands of poorly differentiated cells (Figure 3(f). Histologic recognition and distinction from other benign and malignant lesions with rich stromal lymphoid infiltrate are critical for its management. The tumor shows a close similarity to lymphoepithelioma of the head and neck region. EBV–encoded RNA is not detected, in contrast to a similar tumor of the nasopharyngeal region, this confirming that EBV is not a prerequisite for the development of this histologic variant. Survival analysis shows no differences between lymphoepithelioma-like carcinoma and conventional upper urinary tract urothelial carcinoma [26].
Incidence and survival rates of lymphoepithelioma-like gastric carcinoma: analysis of the Korea Central Cancer Registry Database
Published in Scandinavian Journal of Gastroenterology, 2021
Jin-Woo Kim, Ji-Hoon Kim, Hee Man Kim
Lymphoepithelioma-like gastric carcinoma (LEGC) is a rare type of gastric carcinoma, having various synonyms: lymphoepithelial carcinoma of the stomach, gastric carcinoma with lymphoid stroma, undifferentiated carcinoma with lymphoid stroma, and medullary carcinoma. It was first described by Watanabe as late as 1976 [1]. Lymphoepithelioma-like carcinoma is characterized by peculiar histology of undifferentiated malignant epithelial cells with profound infiltration of lymphoid cells in the stroma. LEGC constitutes approximately 1–4% of all types of gastric carcinoma [2,3]. LEGC is associated with Epstein-Barr virus (EBV) infection, and more than 80% of LEGC have been found to be infected with EBV [4].