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Prostatic Cancer
Published in Dongyou Liu, Tumors and Cancers, 2017
The prostate is affected by primary tumors of six histological categories: (1) epithelial tumors (glandular neoplasms [acinar adenocarcinoma—atrophic, pseudohyperplastic, foamy, colloid, signet ring, oncocytic, lymphoepithelioma-like; carcinoma with spindle cell differentiation—carcinosarcoma, sarcomatoid carcinoma; prostatic intraepithelial neoplasia [PIN]—PIN grade III; ductal adenocarcinoma—cribriform, papillary, solid]; urothelial tumors [urothelial carcinoma]; squamous tumors [adenosquamous carcinoma, squamous cell carcinoma]; basal cell tumors [basal cell adenoma, basal cell carcinoma]), (2) neuroendocrine tumors (endocrine differentiation within adenocarcinoma, carcinoid tumor, small cell carcinoma, paraganglioma, neuroblastoma), (3) prostatic stromal tumors (stromal tumor of uncertain malignant potential, stromal sarcoma), (4) mesenchymal tumors (leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, angiosarcoma, malignant fibrous histiocytoma, malignant peripheral nerve sheath tumor, hemangioma, chondroma, leiomyoma, granular cell tumor, hemangiopericytoma, solitary fibrous tumor), (5) hematolymphoid tumors (lymphoma, leukemia), and (6) miscellaneous tumors (cystadenoma, nephroblastoma [Wilms tumor], rhabdoid tumor, germ cell tumors [yolk sac tumor, seminoma, embryonal carcinoma and teratoma, choriocarcinoma], clear cell carcinoma, melanoma), in addition to a number of metastatic tumors [1].
Large Cell Carcinoma and Large Cell Neuroendocrine Carcinoma of the Lung
Published in Dongyou Liu, Tumors and Cancers, 2017
Differential diagnoses for LCC include poorly differentiated squamous cell carcinoma (foci of keratinization and/or intercellular bridges), solid type adenocarcinoma (a minimum of 5 mucinous droplets in at least 2 HPF), lymphoepithelioma-like carcinoma (syncytial growth pattern with squamoid or glandular differentiation, lymphocytic infiltrate, EBV infection especially in Asian patients), clear cell carcinoma (clear to eosinophilic, finely granular cytoplasm with abundant PAS+ glycogen and stains with melanocytic and smooth muscle markers) [2].
Intermediate risk pulmonary embolism concomitant with or without lung cancer: a wide spectrum of features
Published in Clinical and Experimental Hypertension, 2022
Yu-Jia Jin, Yi-Fan Jin, Xin-Yun Zhu, Bei-Lei Zhang, Cheng Chen
This retrospective study was conducted in the First Affiliated Hospital of Soochow University, and the sample comprised PE patients diagnosed based on CTPA findings from January 2017 to April 2021. Flow chart detailing the selection of the patients in this study was shown in Figure 1. Lung cancer was diagnosed by histological or cytological examination, then classified as adenocarcinoma, carcinoma, adenosquamous carcinoma, small cell carcinoma or lymphoepithelioma-like carcinoma according to the 2015 World Health Organization (WHO) Classification of Tumors of the Lung (4). The patients were categorized into two groups; for patients in the LC group, pulmonary embolism was diagnosed after or at the first diagnosis of lung cancer. Patients were excluded from the sample if there were missing CTPA images, a lack of laboratory data or a diagnosis of cancer other than lung cancer.
Upper urinary tract urothelial carcinoma and its variants: transition from morphology to personalized molecular characterization in diagnosis, prognosis, and therapy
Published in Expert Review of Molecular Diagnostics, 2018
Alessia Cimadamore, Marina Scarpelli, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi
This variant, very rare in the upper urinary tract, shows a dense chronic inflammatory infiltrate surrounding islands of poorly differentiated cells (Figure 3(f). Histologic recognition and distinction from other benign and malignant lesions with rich stromal lymphoid infiltrate are critical for its management. The tumor shows a close similarity to lymphoepithelioma of the head and neck region. EBV–encoded RNA is not detected, in contrast to a similar tumor of the nasopharyngeal region, this confirming that EBV is not a prerequisite for the development of this histologic variant. Survival analysis shows no differences between lymphoepithelioma-like carcinoma and conventional upper urinary tract urothelial carcinoma [26].
Incidence and survival rates of lymphoepithelioma-like gastric carcinoma: analysis of the Korea Central Cancer Registry Database
Published in Scandinavian Journal of Gastroenterology, 2021
Jin-Woo Kim, Ji-Hoon Kim, Hee Man Kim
Lymphoepithelioma-like gastric carcinoma (LEGC) is a rare type of gastric carcinoma, having various synonyms: lymphoepithelial carcinoma of the stomach, gastric carcinoma with lymphoid stroma, undifferentiated carcinoma with lymphoid stroma, and medullary carcinoma. It was first described by Watanabe as late as 1976 [1]. Lymphoepithelioma-like carcinoma is characterized by peculiar histology of undifferentiated malignant epithelial cells with profound infiltration of lymphoid cells in the stroma. LEGC constitutes approximately 1–4% of all types of gastric carcinoma [2,3]. LEGC is associated with Epstein-Barr virus (EBV) infection, and more than 80% of LEGC have been found to be infected with EBV [4].