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Rheology of Cerebrovascular Disease
Published in Gordon D. O. Lowe, Clinical Blood Rheology, 2019
It is important to recognize those patients in whom hemodilution therapy is unlikely to be of value. First, where the potential for collateral flow is poor, for example in infarcts from thrombi of the perforating lenticulo-striate arteries or perforating branches of the basilar to the brain stem, hemodilution may not be as effective as in infarcts elsewhere. As yet it is not clear whether hemodilution is to be recommended in patients with cerebral hemorrhage. Where there is poor cardiac function, hemodilution has to be used with care. In more enthusiastic centers, it has been recommended that pulmonary wedge pressure be monitored, so that early signs of cardiac decompensation can be detected and hemodilution therapy modified accordingly.
Thrombolytic Therapy
Published in Genesio Murano, Rodger L. Bick, Basic Concepts of Hemostasis and Thrombosis, 2019
Genesio Murano, Rodger L. Bick
Activation of the fibrinolytic system by urokinase or streptokinase results in seriously compromised hemostatic function. This is attributed to the generalized intravascular proteolysis (GIP) introduced by plasmin (Table 2). As a consequence, hemorrhage (in varying degrees) occasionally occurs. Severe spontaneous bleeding, including cerebral, retroperitoneal, and gastrointestinal has been documented in less than 5°7o of the patients treated. Several fatalities due to cerebral hemorrhage have occurred.
Mechanisms of Fibril Formation and Cellular Response
Published in Martha Skinner, John L. Berk, Lawreen H. Connors, David C. Seldin, XIth International Symposium on Amyloidosis, 2007
Martha Skinner, John L. Berk, Lawreen H. Connors, David C. Seldin
Consecutive 8 CAA ATTR Tyr114Cys patients who examined at Kumamoto University from 1998 to September 2006 were involved in this study. Clinical manifestations of three patients with ATTR Tyr114Cys who underwent liver transplantation after the onset of peripheral neuropathy were compared with those of five non-transplanted patients with ATTR Tyr114Cys. Brain CT scan was performed to evaluate cerebral hemorrhage, and volumes of hemorrhage were calculated. The volumes of cerebral hemorrhage were statistically analyzed in Student’s t test and p<0.05 were considered statistically significant.
Assessment of rehabilitation following intracerebral hemorrhage in China: findings from the Chinese stroke center alliance
Published in Neurological Research, 2023
Jin-Ju Sun, Yong-Mei Deng, Dan-Dan Wang, Hong-Qiu Gu, Qi Zhou, Yong-Jun Wang, Zi-Xiao Li, Xing-Quan Zhao
This study provides important new evidence for the rehabilitation assessment of patients with acute cerebral hemorrhage. The results of the study showed that among the patients hospitalized for ICH, the rate of rehabilitation assessment was 74.2%, which is low. Rehabilitation assessment may influence longer hospital stays and mortality. Therefore, patients with acute cerebral haemorrhage should undergo comprehensive and professional rehabilitation assessment. Future studies should clarify rehabilitation assessment methods, the timing of patient evaluations, and the role of the assessors to improve the quality of stroke care and meet the needs of patients. Furthermore, it is important to strengthen the training of rehabilitation professionals to meet the needs of patients in the context of comprehensive rehabilitation.
Synergistic deterioration of prognosis associated with decreased grip strength and hyporesponse to erythropoiesis-stimulating agents in patients undergoing hemodialysis
Published in Renal Failure, 2022
Shizuka Kobayashi, Kentaro Tanaka, Junichi Hoshino, Shigeko Hara, Akifumi Kushiyama, Yoshihide Tanaka, Shuta Motonishi, Ken Sakai, Takashi Ozawa
All causes of death were defined as all-cause mortality. Cardiovascular disease was defined as ischemic cardiovascular events (angina, myocardial infarction, arteriosclerosis obliterans, cerebral hemorrhage, and cerebral infarction), or nonischemic heart disease events (heart failure). In the survival analysis, if a patient experienced both events, the first event took precedence. The observation period was 2 years. In our study, we observed events with a composite endpoint. However, we performed a separate multivariate analysis for all-cause mortality and cardiovascular disease. Angina pectoris and myocardial infarction were diagnosed using coronary angiography and myocardial scintigraphy, while arteriosclerosis obliterans was screened with ankle-brachial index (ABI) and diagnosed by a specialist using lower extremity ultrasound, contrast-enhanced computed tomography (CT), or magnetic resonance imaging (MRI). Cerebral hemorrhage and infarction were diagnosed based on imaging findings, such as CT and MRI.
Experimental study on the detection of cerebral hemorrhage in rabbits based on broadband antenna technology
Published in Computer Assisted Surgery, 2019
Haisheng Zhang, Mingsheng Chen, Gui Jin, Jia Xu, Mingxin Qin
Cerebral hemorrhage refers to the bleeding caused by vascular rupture in the brain parenchyma, which has the characteristics of high incidence, high mortality and high morbidity [1]. Clinical studies have shown that cerebral hemorrhage is gradually aggravated, the hematoma often expands rapidly within a few hours [2], but sometimes this process lasts for several days. According to continuous CT examination of 204 patients with acute cerebral hemorrhage [3], 41 cases of hematoma expansion appear in the CT review. The most common hematoma enlargement occur within 6 hours, 15% of all occur in 6–12 hours, and 6% of all occurred within 12–24 hours, the hematoma of patients with coagulation disorders even expanded within a few days [4]. For patients with cerebral hemorrhage, hematoma enlargement is a common clinical phenomenon, which seriously threatens patient’s life and prognosis [5]. So real-time monitoring of hematoma and timely clinical intervention is the key to successful treatment of patients with cerebral hemorrhage.