China
Africa
Explore chapters and articles related to this topic
Nanotechnological Strategies for Engineering Complex Tissues
Published in Lajos P. Balogh, Nano-Enabled Medical Applications, 2020
Tal Dvir, Brian P. Timko, Daniel S. Kohane, Robert Langer
Organ transplantation is limited by the number of available donors and high process cost, leaving thousands of people each year on the transplant waiting lists in the United States alone. Many die before an organ donor becomes available. Tissue engineering has evolved as an interdisciplinary technology combining principles from the life, material and engineering sciences with the goal of developing functional substitutes for these damaged tissues and organs [1]. Rather than simply introducing cells into a diseased area to repopulate a defect and/or restore function, in tissue engineering the cells are often seeded in or onto biomaterials before transplantation. These materials serve as temporary scaffolds and promote the reorganization of the cells to form a functional tissue [1] (Fig. 12.1).
Clinical Progresses in Regenerative Dentistry and Dental Tissue Engineering
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Tissue engineering can be defined as an interdisciplinary field that applies the principles of engineering and life sciences towards the development of biological substitutes that restore, maintain or improve tissue function (Langer and Vacanti 1993).
Tissue Engineering and Cell Therapies for Neurogenic Bladder Augmentation and Urinary Continence Restoration
Published in Jacques Corcos, Gilles Karsenty, Thomas Kessler, David Ginsberg, Essentials of the Adult Neurogenic Bladder, 2020
3D printing has recently emerged as one of the most promising technologies in the field of tissue engineering.31 It relies on a methodology known as additive manufacturing, which uses digital data of a 3D structure and converts it into an actual object. In contrast to the classical tissue engineering process that involves scaffolds, 3D printing creates complex structures from the bottom-up.
Use of Decellularized SMILE (Small-Incision Lenticule Extraction) Lenticules for Engineering the Corneal Endothelial Layer: A Proof-of-Concept
Published in Current Eye Research, 2023
Swatilekha Hazra, Jacquelyn Akepogu, Supriya Krishna, SriRavali Pulipaka, Bhupesh Bagga, Charanya Ramachandran
The cornea is one of the most transplanted tissues globally, accounting for ∼180,000 surgeries in a single year in over 116 countries. Yet, only 1 healthy tissue is available for every 70 that are required leaving nearly 12.7 million people awaiting transplantation.1 Of the total corneal transplants performed in a given year, nearly 40% of them are done to replace the dysfunctional corneal endothelium (CE).2 Engineering the endothelial layer, therefore, would provide a much-needed alternative to donor tissues. Tissue engineering involves two important steps: the first is the generation of the native cells and the second is the material used to construct the tissue. Many synthetic and biological materials have been used for constructing the CE layer.3–9 Of particular interest is the corneal stroma since it retains all the required features of the native tissue allowing for better integration after transplantation. In recent times, lenticules that are extracted during refractive surgery (Small Incision Lenticule Extraction or SMILE) have garnered interest since they provide a cadaver-donor independent source of corneal stroma and are readily available. These lenticules are increasingly being used as implants to correct hyperopia,10,11 presbyopia,12,13 as grafts to treat tears/perforations14–16 and for constructing corneal equivalents.17,18
Injectable and adhesive hydrogels for dealing with wounds
Published in Expert Opinion on Biological Therapy, 2022
Parisa Ghandforoushan, Nasim Golafshan, Firoz Babu Kadumudi, Miguel Castilho, Alireza Dolatshahi-Pirouz, Gorka Orive
Tissue engineering and regenerative medicine are emerging as the future trends of medicine for the treatment of acute and chronic diseases. Due to their specificity, hydrogels have been recognized as a new gateway in biological materials to treat dysfunctional tissues. The design and creation of injectable hydrogel-based scaffolds have extensively progressed in recent years to improve their therapeutic efficacy and also to pave the way for their easy minimally invasive administration. Advances in our perception around regenerative biomaterials and their definite position in the formation of new tissues can open up new frontiers in regenerative medicine and empower scientists to fabricate tissues and organs in the laboratory. We hypothesize that this new course will be accompanied by the usage of injectable hydrogels and adhesives with significant clinical advances in wound healing treatments.
Cell-Biomaterial constructs for wound healing and skin regeneration
Published in Drug Metabolism Reviews, 2022
Ingrid Safina, Luke T. Childress, Srinivas R. Myneni, Kieng Bao Vang, Alexandru S. Biris
The ultimate goal in tissue engineering is to develop a tissue that closely resembles, in structure and function, a normal tissue to replace damaged ones. As previously mentioned in this review, there are many FDA-approved bioengineered skin substitutes commercially available for direct application, many others currently under development, and others being assessed for in vivo applications. To the best of our knowledge, although these substitutes are structurally similar to normal human skin, they provide barrier function at best, with minimal restoration of skin appendages and vascular and nerve systems. This lack of complete restoration leads us to conclude that no true regeneration happens from the application of these substitutes. However, considering all the progress that has been achieved and current undertakings, we believe that the field is on its way to producing advanced skin substitutes that will, one day, lead to complete regeneration of a functional skin, as long as interdisciplinarity in material engineering, biology, and clinical science is maintained.