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Three-Dimensional Printing: Future of Pharmaceutical Industry
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Manju Bala, Anju Dhiman, Harish Dureja, Munish Garg, Pooja A Chawla, Viney Chawla
The use of 3D printing in medicine is now close to become a reality. 3D printing consists of three main pillars: one is to utilise less time, second is to treat a large number of people, and third is to receive more outcome. In brief, 3D printing is made up of one sentence ‘enable less physicians to treat more patients without any scarification of results’. 3D printing has opened new ways for the pharmaceutical industry. The on-demand printing of medicines is possible by emailing their database of medicines to pharmacies, which further help the pharmaceutical sector in formulating a cost-effective method of manufacturing and distributing of medicines. The medicines made by this way will increase the patient adherence. In future, it may lead to development in garage biology. As this technique is latest, so due to no regulation, security and safety are required for 3D printing. As a latest technique, 3D printing has proposed many applications in the medical sector. A new door has opened to a newer generation of advanced system of drug delivery by combination of the conventional method of manufacturing in the pharmaceutical industry with 3D printing. We believe that perseverance and patience in 3D printing can develop a safe and effective system of pharmaceutical dosage form.
The Concept of Biocompatibility
Published in Antonietta Morena Gatti, Stefano Montanari, Advances in Nanopathology From Vaccines to Food, 2021
Antonietta Morena Gatti, Stefano Montanari
A big boost to prosthesis production comes from 3D technology. Born to reproduce small things such as toys, 3D printing is increasingly proving to be an exceptional tool to produce customised prostheses as well as in various specialties of surgery [6]. This new method allows us to manufacture prostheses built exactly on the patient, with obviously better results than those obtained from industrial products, which can also be of the highest quality but, however, mass-produced without being able to take into account the individual case.
Left Atrium
Published in Takahiro Shiota, 3D Echocardiography, 2020
Charles Fauvel, Olivier Raitière, Fabrice Bauer
The global 3D printing market is expected to expand as a response to growing demand for prototyping in various fields including health care. In the medical field, 3D printing allows for the creation of patient-specific organs and touchable replicas that students can use to learn and surgeons can use to practice on before performing complicated operations. A 3D printing of the left atrium is obtained from layer-by-layer addition of specific material to form an object referring to a 3D file postprocessed from a regular CT scan, magnetic resonance imaging (MRI), or less frequently 3D echocardiography with the help of software and a 3D printer (). Some publications highlight the use of 3D printing for sizing and selecting left atrial appendage closure devices,1,2 illustrating and closing atrial septal defect (ASD).3,4Figure 5.1 is a versatile method that enables a more comprehensive study of LA structures, especially complex anatomy and simulated device implantation.
Advances in additive manufacturing processes and their use for the fabrication of lower limb prosthetic devices
Published in Expert Review of Medical Devices, 2023
Shaurya Bhatt, Deepak Joshi, Pawan Kumar Rakesh, Anoop Kant Godiyal
Although the application of 3D printing for the fabrication of prosthesis has been limited, 3D printing finds its application in many other fields related to rehabilitation. AM has been used in the production of custom orthoses for many years [68]. The most commonly fabricated custom orthotic devices are foot orthoses (FOs) and ankle-foot orthoses (AFOs). SLS custom-made FOs help redistribute body force over the arch and heel for patients with rheumatoid arthritis [84]. 3D printing has also been used to produce shoe insoles to reduce heel and forefoot pressure and redistribute the pressure to the foot arch [85]. SLS has also been used to produce AFOs using glass fiber filled with nylon to replace carbon fiber AFOs [86]. On comparison of AFOs made by SLA with conventional AFOs using gait study, it was found that AFOs made by SLA showed equivalent walking speed and step length, while the support time increased two times [87].
Future prospects in 3-dimensional (3D) technology and Mohs micrographic surgery
Published in Journal of Dermatological Treatment, 2022
Stephanie Ishack, Amor Khachemoune
The advancement of three-dimensional (3D) bioprinting has allowed for innovative and revolutionary changes within the field of regenerative medicine. Three-dimensional (3D) skin printing is a transformative technology used to fabricate biomimetic scaffold architectures which mimic human skin. 3D bioprinting uses a robotic stage and computer-aided design (CAD) systems to design layered tissue medical devices made from biomaterials. There are three major types of biological printing: inkjet-based bioprinting, laser-assisted bioprinting (LAB), and pressure-assisted bioprinting (1). Most of the applications of 3D printing in surgery focus on these three categories: surgical 3D models, surgical guides, and implants. Moreover, 3D printing software can be used to extract digital data from patients through the use of computed tomography, magnetic resonance imaging or computational laser scanning. These tools allow for custom-made and personalized skin constructs that can be used for scaffold implantation during Mohs micrographic surgery (MMS).
Three-dimensional bioprinting of artificial ovaries by an extrusion-based method using gelatin-methacryloyl bioink
Published in Climacteric, 2022
T. Wu, Y. Y. Gao, J. Su, X. N. Tang, Q. Chen, L. W. Ma, J. J. Zhang, J. M. Wu, S. X. Wang
Much work needs be done to confirm the efficacy of 3D bioprinting in the reproductive medicine field, such as further animal experiments, more complex printed architecture and comparison with conventional in vitro follicle culturing. The 3D printing system is sophisticated and requires expensive equipment, which limits its clinical application. An artificial ovary should enable both restoration of fertility and resumption of endocrine function. In terms of seeding cells, most studies used adult somatic cells. Cell-based hormone replacement constructs, containing GCs and theca cells, could function for as long as 90 days [9]. Adding mesenchymal stem cells or progenitor cells of GCs or TICs to the artificial ovary construction may further prolong function. Stem cells might be advantageous for ovarian bioengineering since they support GCs and steroid secretion and have follicle-rejuvenating effects when transplanted into the ovary [51–53].