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Venereal diseases
Published in Dinesh Kumar Jain, Homeopathy, 2022
Next disease, lymphogranuloma venereum, is a sexually transmitted infection, caused by Chlamydia trachomatis. It is characterized byInfection of lymph channels and lymph nodes manifesting by bubo formation, ulcerations, enlargement of genital organs and rectal stricture. Fever, chills, headache and joint pains may also be present. Abscess formation with drainage of pus from the inguinal lymph nodes is usual. Later manifestations of disease include secondary ulceration and elephantiasis of genitals in both sexes, polypoid growths about the anus, and inflammation, ulceration and stricture of rectum.(Fleming, 1973, p. 242)
The gastrointestinal system
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
Sharon J. White, Francis A. Carey
Fungal infections of the alimentary tract are rare, but are being seen increasingly in immunocompromised patients. In such instances, normally non-pathogenic phycomycetes are often found. Lymphogranuloma venereum is a sexually transmitted infection caused by specific serotypes of Chlamydia trachomatis. It is usually seen in females, and may cause rectal strictures by spreading to the rectum via the lymphatics. The histological picture is characterized by granulomas and non-specific chronic inflammation.
Chlamydia Pneumonitis
Published in Lourdes R. Laraya-Cuasay, Walter T. Hughes, Interstitial Lung Diseases in Children, 2019
The epidemiology of each Chlamydia species is different. C. psittaci primarily cause disease in birds and animals, with humans as only incidental hosts. C. trachomatis however, cause disease in humans which are spread by close personal contact. Lymphogranuloma venereum, nongonococcal urethritis, and cervicitis are sexually transmitted diseases.
Genital ulceration in adolescent girls: a diagnostic challenge
Published in Journal of Obstetrics and Gynaecology, 2021
Anastasia Vatopoulou, Konstantinos Dinas, Evangelia Deligeoroglou, Alexis Papanikolaou
Non-sexually acquired acute vulvar ulceration was first described by Benjamin Lipschütz in 1912 in Vienna and it was initially referred as ‘ulcus pseudonereum’. Ιt was named after him and referred in the literature as Lipschütz’s ulcer. The differential diagnosis of acute genital ulcerations includes sexually and non-STIs, treatment with anti-inflammatory non-steroidal agents, autoimmune conditions, local manifestations of systemic illnesses and idiopathic aphthosis. Sexually transmitted infections characterised by genital ulcers include genital HSV infection, syphilis, chancroid, lymphogranuloma venereum and HIV infection. Non-STIs include cytomegalovirus, paratyphoid, influenza A and EBV infection. Hormonal changes may also play a role in genital ulcerations. Finally, leukaemia and other malignancies may have similar genital manifestations (Huppert 2010). In a large retrospective series of 273 patients with genital ulceration, the incidence of Lipschütz’s ulcer was 36% (Schindler Leal et al. 2018).
A profile of the cobas® CT/NG assay on the cobas® 6800/8800 system for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
Published in Expert Review of Molecular Diagnostics, 2020
Three significant needs remain regarding chlamydia and gonorrhea molecular diagnostics. The first is a mechanism for identifying chlamydia-positive anorectal samples to biovar level. C. trachomatis is comprised of three biovars: those that cause ocular infection (not related to mother-to-child transmission during labor and delivery), the genital strains, and Lymphogranuloma Venereum (LGV). LGV is a more aggressive pathogen that can disseminate to lymph nodes and cause proctitis, lymphadenopathy and inguinal buboes [21]. As the rates of LGV among men who have sex with men have increased over the last 15 years, public health agencies have called for diagnostic tools that can distinguish these infections from other biovars of C. trachomatis in order to manage patients appropriately [22,23]. The ideal solution would be the addition of an LGV-specific probe that could simultaneously detect infection and identify the biovar. Less optimal, but still useful would be a reflex test that could be used only on those specimens that gave an initial positive result. This process would be slower and more expensive but would still provide actionable information to clinical healthcare providers.
Review of Chlamydia trachomatis viability methods: assessing the clinical diagnostic impact of NAAT positive results
Published in Expert Review of Molecular Diagnostics, 2018
Kevin J. H. Janssen, Jeanne A. M. C. Dirks, Nicole H. T. M. Dukers-Muijrers, Christian J. P. A. Hoebe, Petra F. G. Wolffs
Chlamydia trachomatis (chlamydia) is the most common bacterial sexually transmitted infection (STI) globally. A total number of 131 million new cases of chlamydia infections occurred in adults worldwide in 2012 [1]. Chlamydia trachomatis strains can be divided into three biovars, based on clinical implications and pathogenesis, and can be further subtyped into serological variants (serovars); the ocular trachoma biovar (serovar A-C), genital biovar (serovar D-K), and the invasive lymphogranuloma venereum (LGV) biovar (serovar L1-L3) [2]. The clinical picture is highly variable, and ranges from virtually no symptoms to symptoms of urethritis, intermenstrual bleeding, and vaginal or urethral discharge [3]. Complications arise mostly in women where chlamydia can result in pelvic inflammatory disease (inflammation of female reproductive organs), which in turn can lead to chronic abdominal pain, ectopic pregnancy and tubal factor infertility [3].