China
Africa
Explore chapters and articles related to this topic
Curative Properties of Chamomile in Gastrointestinal Disorders
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Mouth ulcers are associated with a number of etiologies.20 Stomatitis is the main dose-limiting toxicity for chemotherapy regimens dependent on 5-fluorouracil (5-FU) bolus. There was a double-blind, placebo-controlled clinical trial with 164 volunteers. At the time of their first 5-FU-based chemotherapy phase, patients were admitted into the study and randomized for 14 days of accepted chamomile liquid formulation three times in a day.18 In case of stomatitis, no significant difference was observed among the clinical trial volunteers. No toxicity was reported. The same outcome was acquired in this condition by other chamomile trials. The pre-study theory was not assisted by evidence of clinical studies that chamomile could decrease stomatitis induced by 5-FU. Whether chamomile is beneficial in this case, the findings remain unclear.
Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
In the period 1985–1998, in a Stomatology Center in the USA, 65 cases were found classified as contact stomatitis caused by cinnamon flavoring agents. In 37 of the 65 cases, causative agents were identified, and the signs and symptoms disappeared after the patients discontinued the use of these agents (foods, toothpastes, and chewing gums). Fifteen of the 37 patients were patch tested with cinnamic acid 5% pet. and cinnamal 2% pet. (which may induce irritant reactions), and 12 reacted positively (not specified to which of the test materials). In 26 patients, toothpastes were considered to be the causative agents or contributory (in combination with foods and/or chewing gum). In nine of these, patch tests had been performed with the cinnamon-derivatives, but, again, it was not specified how many and which ones were positive. The most frequent symptoms and signs of stomatitis were erythema (gingiva, buccal mucosa, tongue) (n=8), epithelial sloughing (n=5) and burning or sore mouth (n=5) (4).
Adverse drug reactions on the skin
Published in Robert A. Norman, Geriatric Dermatology, 2020
The Stevens–Johnson syndrome, a severe and occasionally fatal variety of erythema multiforme, has an abrupt onset and is accompanied by any or all of the following: fever, myalgia, malaise, headache, arthralagia and ocular involvement, with occasional bullae and erosions covering less than 10% of the body surface. Painful stomatitis is an early and conspicuous symptom. Hemorrhagic bullae may appear over the lips, mouth and genital mucous membranes. Patients are often acutely ill with high fever. The course from eruption to healing of the lesions may extend up to six weeks.
Evaluating everolimus for the treatment of breast cancer
Published in Expert Opinion on Pharmacotherapy, 2023
Camille Moreau-Bachelard, Marie Robert, Carole Gourmelon, Emmanuelle Bourbouloux, Anne Patsouris, Jean-Sébastien Frenel, Mario Campone
The mean rate of stomatitis with everolimus was 67% [36]. Most stomatitis events were grade 1/2, with grade 3/4 events retrieved in 9% of the patients. In BOLERO-2 study, the most common grade 3/4 adverse events were stomatitis (8% vs 1%), anemia (6% vs < 1%), dyspnea (4% vs 1%), hyperglycemia (4% vs < 1%), fatigue (4% vs 1%), and pneumonitis (3% vs 0%) in the experimental arm and in the control arm, respectively, [22]. Primary prevention of stomatitis must be carried out. In the SWISH Phase II study to prevent the development of stomatitis, dexamethasone mouthwash reduced the proportion of all grades of stomatitis by 61% and grade 2 or worse stomatitis by 91% compared to BOLERO-2 after 8 weeks of treatment [37]. The number of pneumonia is also consequent and patients must be warned, appropriate scan monitoring is necessary. A study confirm that this combination provides clinical benefit without harming health-related quality of life in patients with HR-positive ABC who recurred/progressed on prior non-steroid AI vs endocrine therapy alone [38].
Real-Life Analysis of Efficacy and Safety of Everolimus Plus Exemestane in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor-2-Negative Metastatic Breast Cancer Patients: A Turkish Oncology Group (TOG) Study
Published in Cancer Investigation, 2022
Ahmet Bilici, Mukremin Uysal, Serkan Menekse, Semih Akin, Fatih Yildiz, Merve Turan, Sema Sezgin Goksu, Ismail Beypinar, Teoman Sakalar, Mustafa Değirmenci, Dilek Erdem, Gul Basaran, Omer Fatih Olmez, Nilufer Avci, Deniz Tural, Abdullah Sakin, Sema Turker, Atakan Demir, Suleyman Temiz, Muhammed Ali Kaplan, Mutlu Dogan, Ozgur Tanriverdi, Irem Bilgetekin, Havva Yesil Cinkir, Ozgur Acikgoz, Semra Paydas, Ruchan Uslu, Serdar Turhal
All patients initiated treatments at the standard 10 mg daily dose. The most frequent reason for treatment discontinuation was disease progression (53.4%). Treatment was discontinued in eight patients (3.9%) because of toxic events. Owing to toxic events, the EVE dosage was reduced to 5 mg in 27 patients (13.2%). Most patients had grade 1 (58.6%) to grade 2 AEs (36.5%). The most commonly reported AEs were stomatitis (48.0%), asthenia (44.6%), elevated ALT or AST levels (18.1%), and arthralgia (17.6%). Grade 3–4 AEs were noted in 26.0% of patients, including stomatitis in 6.8% of cases and non-infectious pneumonitis (NIP) in 2.5% of cases with other grade 3–4 AEs in less than 2% of patients (Table 5). Most patients (92.1%, n = 188) used dexamethasone mouthwash (alcohol-free steroid-based mouthwash-0.5 mg/5 ml dexamethasone oral solution) as the primary prophylaxis to prevent stomatitis.
Oral prosthetic microbiology: aspects related to the oral microbiome, surface properties, and strategies for controlling biofilms
Published in Biofouling, 2021
Douglas Roberto Monteiro, Victor Eduardo de Souza Batista, Anne Caroline Morais Caldeirão, Rogério de Castilho Jacinto, Juliano Pelim Pessan
Denture stomatitis is a disease characterized by inflamed or erythematous areas of the oral mucosa for denture support (Gendreau and Loewy 2011), as illustrated in Figure 1. It is often an asymptomatic condition, despite some individuals experiencing pain, itching, or burning sensations in the edentulous areas covered by the dentures (Talapko et al.2021). Prevalence rates range from 2.5 to 77.5% depending on the age of the population, the geographic region, the type of prosthesis evaluated, and the method used to diagnose the disease (Gendreau and Loewy 2011). Its aetiology is multifactorial, including Candida infection, oral mucosal pH below 6.5, prolonged time of use (which increases mucosal exposure to denture biofilm), nocturnal use of dentures, maladaptative-related trauma, inadequate hygiene, and systemic disorders with immunocompromise (Gendreau and Loewy 2011; Marinoski et al.2014).