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Hepatoprotective Marine Phytochemicals
Published in Se-Kwon Kim, Marine Biochemistry, 2023
BR Annapoorna, S Vasudevan, K Sindhu, V Vani, V Nivya, VP Venkateish, P Madan Kumar
Liver cancer is an inflammation-driven liver disease preceded chiefly by hepatitis viral infection and nonalcoholic steatohepatitis (NASH). Based on the types of cells that become cancerous, liver cancer is categorized into primary liver tumors, which include hepatocellular carcinoma (HCC), fibrolamellar carcinoma, cholangiocarcinoma, hepatoblastoma, and mesenchymal cancers of the liver. Liver cancer is the sixth-most common cancer and the third-largest cause of cancer mortality worldwide in 2020, with approximately 906,000 new cases and 830,000 deaths. It is two to three times higher among men than in women and liver cancer ranks fifth in terms of global incidence and second in terms of mortality for men. Liver cancer is the leading cause of cancer death in Mongolia, Thailand, Cambodia, Egypt, and Guatemala among both men and women and in an additional 18 countries among men. Primary liver cancer includes HCC and intrahepatic cholangiocarcinoma. Globally, HCC is the dominant type of liver cancer, accounting for approximately 75% of all liver cancers (Sung et al. 2021). Most HCC cases (>80%) occur in either sub-Saharan Africa or in Eastern Asia (El-Serag and Rudolph 2007). The highest incidence rates in the world are found in Asia and Africa (Petrick et al. 2020). Most Asian countries are in the intermediate- to high-incidence zones of HCC. However, India falls in the low incidence zone. About 42,230 U.S. adults are expected to be diagnosed with liver cancer in 2021, according to the American Society of Clinical Oncology.
Histopathological Cancer Detection Using CNN
Published in Meenu Gupta, Rachna Jain, Arun Solanki, Fadi Al-Turjman, Cancer Prediction for Industrial IoT 4.0: A Machine Learning Perspective, 2021
Soham Taneja, Rishika Garg, Preeti Nagrath, Bhawna Gupta
Hepatic (Liver) Cancer – This cancer begins in the cells of the liver. Its symptoms also tend to be physical, and it usually requires complex procedures as treatment. Like lung cancer, this cancer also spreads to other organs fast due to the proximity, decreasing the chances of survival. Therefore, like all other cancers, early detection is key. We went through some of the research work done with respect to this cancer [20] and expect our method to fare well.
Viral hepatitis in pregnancy
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
A patient who is not a hepatitis B treatment candidate during pregnancy may be a candidate for treatment at a later point in time. Therefore, it should be emphasized to the patient that she should continue to follow up with the gastroenterologist/hepatologist after delivery. Hepatitis B is a chronic disease that requires regular monitoring and liver cancer screening in at risk patients. The clinicians caring for these pregnant patients have the golden opportunity of providing education regarding hepatitis B and also to ensure that patients continue to follow up with specialists.
Microwave ablation of multifocal primary liver cancer guided by real-time 3.0T MRI
Published in International Journal of Hyperthermia, 2023
Fenghai Liu, Baozhou Hou, Zhuofu Li, Lei Zhang, Yingwen Zhou, Hao Bian, Zhaoyang Huo
Liver cancer is a highly malignant tumor and a common carcinoma. Its morbidity and mortality are on the rise globally. According to the estimation of the International Agency for Research on Cancer (IARC), about 905,000 people suffered from liver cancer in 2020, causing 830,000 deaths worldwide [1]. Surgical resection is considered the preferred method for the treatment of primary liver cancer [2]. Most multifocal liver cancers have tumors located in different liver segments. Therefore, the surgical resection rate of such tumors is relatively low, and treatment methods such as transcatheter arterial chemoembolization (TACE), local ablation, or liver transplantation are mostly used [3–5]. However, the long-term efficacy of TACE is unsatisfactory, especially for multifocal liver cancer [6]. Liver transplantation is difficult to popularize due to the shortage of donor organs, high cost, and life-long immune maintenance of recipients. With the development of modern imaging, local ablation is increasingly used for clinical cancer treatment.
Meat Intake and the Risk of Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies
Published in Nutrition and Cancer, 2022
Jinchuan Yu, Zhengxiang Liu, Di Liang, Jiujiu Li, Shaodi Ma, Guangjun Wang, Wenjun Chen
Hepatocellular carcinoma is the most common primary liver cancer and is an important medical issue. Liver cancer is the third leading cause of cancer-related death and ranks sixth in terms of new cases worldwide.1 According to the World Health Organization, more than one million patients will die from liver cancer in 2030.2 The main risk factors for liver cancer include chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV), nonalcoholic fatty liver disease (NAFLD), aflatoxin exposure, alcohol abuse, and metabolic diseases such as obesity and diabetes.3 The HCC burden is highest in East Asia and Africa. Approximately 72% of all liver cancer cases occur in Asia, with China accounting for 47% of the world’s burden.4 In recent years, the incidence and mortality of HCC have risen rapidly in the US and Europe, which may be partly due to the prevalence of obesity and diabetes.5
Curcumin reverses hepatic epithelial mesenchymal transition induced by trichloroethylene by inhibiting IL-6R/STAT3
Published in Toxicology Mechanisms and Methods, 2021
Weiya Cao, Yinci Zhang, Amin Li, Pan Yu, Li Song, Jiaojiao Liang, Niandie Cao, Jiafeng Gao, Ruyue Xu, Yongfang Ma, Xiaolong Tang
Liver inflammation occurs in environmental toxic stimulation and tumor microenvironment (Wang, Li, et al. 2020). According to a large-scale epidemiological survey, EMT is the most important factor in the carcinogenic effect of toxicant-related liver inflammation (Yan et al. 2017). The more severe EMT transformation, the higher the risk of tumor. Patients with liver cancer are mainly treated by surgery, supplemented by other treatment strategies, such as chemotherapy and radiotherapy (Anwanwan et al. 2020). However, chemotherapy drugs often have significant side effects, which seriously harm the immune and hematopoietic systems. Plant purification has a reliable antitumor effect, which is reported in clinical and experimental studies (Kuo et al. 2009; Zhou et al. 2012). Therefore, many scholars try to prevent and treat the mechanism of curcumin in the prevention and treatment of liver cancer. Curcumin has a significant inhibitory effect on inflammatory diseases (Menon and Sudheer 2007). Curcumin extracted from Curcuma has a significant inhibitory effect on human hepatoma cell line growth and apoptosis (Marquardt et al. 2015). TCE induces inflammation obviously (Wang et al. 2019), and inflammation can promote the transformation of the epithelial stroma. Curcumin has significant antitumor activity in human cancer cell lines. However, the effect of curcumin on hepatitis induced by TCE has not been studied so far.