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Dyspepsia
Published in Peter Smith, David Colin-Thomé, Guide to the Primary Care Guidelines, 2022
Peter Smith, David Colin-Thomé
In some patients with an inadequate response to therapy or new emergent symptoms, it may become appropriate to refer to a specialist for a second opinion. Emphasise the benign nature of dyspepsia. Review long-term patient care at least annually through discussion of medication and symptoms with patient.
Gastrointestinal Diseases
Published in Miriam Orcutt, Clare Shortall, Sarah Walpole, Aula Abbara, Sylvia Garry, Rita Issa, Alimuddin Zumla, Ibrahim Abubakar, Handbook of Refugee Health, 2021
Dyspepsia is a common symptom complex that requires evaluation for identifiable causes, including gastro-oesophageal reflux, peptic ulcer disease, H. pylori infection, medications, alcohol, biliary tract disease, gastroparesis, systemic/metabolic disease, carbohydrate malabsorption, coeliac disease, gastrointestinal malignancies and pregnancy. Complications are less available – attention to early prevention, diagnosis and management is required.
Rational Medical Therapy of Functional GI Disorders
Published in Kevin W. Olden, Handbook of Functional Gastrointestinal Disorders, 2020
Richard M. Sperling, Kenneth R. McQuaid
Dyspepsia is present in up to one-fourth of the population and is a frequent cause of medical consultation. The term dyspepsia is vague and has been used by physicians variably to refer to a host of symptoms, including upper-abdominal pain, bloating, postprandial fullness, nausea, early satiety, heartburn, or regurgitation (8,10). More recently, it has been defined by a panel of clinical investigators as an episodic or persistent abdominal discomfort located in the upper abdomen or epigastrium (8,93). Dyspepsia may be caused by a host of “organic” factors, including peptic ulcer disease, gastroesophageal reflux, gastroparesis, biliary-tract disease, pancreatic disease, mediations, and various systemic conditions.
A giant solitary fibrous tumour of the liver: a case report
Published in Acta Chirurgica Belgica, 2023
Jan Roman, Petr Vávra, Michaela Vávrová, Vladimír Židlík, Anton Pelikán
During the follow-up (consisting of clinical check-ups every six months with blood work including tumour markers), there was a slow gradual increase of the lesion’s size. At the end of 2019, the patient became symptomatic, presenting with severe dyspepsia and pain following food ingestion. These symptoms greatly limited peroral intake. The lesion was well defined during the clinical examination, extending from the right upper quadrant of the abdomen to the left, crossing the medial line. It was homogenous, slightly pendulating, without signs of fixation to surrounding structures. Skin was regularly coloured, with enlarged superficial veins. A current abdominal CT was performed, showing the tumour, now sized 30 × 25 × 20 cm, suspected to originate from the ventral portion of the liver (Figure 1(D)). The tumour mass caused compression of both ureters resulting in grade 2 to 3 obstructive nephropathy bilaterally (treated by stenting both ureters during the preoperative stage). Due to worsened symptoms, a surgical revision was recommended again. In case of inoperability, a tumour biopsy and cytoreductive surgery was considered. This proposition was accepted by the patient.
Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment
Published in Journal of Drug Targeting, 2021
Larissa Spósito, Giovanna Capaldi Fortunato, Bruna Almeida Furquim de Camargo, Matheus Aparecido dos Santos Ramos, Maurício Palmeira Chaves de Souza, Andréia Bagliotti Meneguin, Taís Maria Bauab, Marlus Chorilli
The symptoms associated with the presence of PUD are variable and often alarming. The most common typical symptoms include the manifestation of epigastric pain, relieved or worsened with meals, events generally indicate the presence of duodenal or gastric ulcers, respectively [15]. Events such as dyspepsia, vomiting, loss of appetite, and intolerance to fatty foods are also common. The development of anaemia, haematemesis, and melena suggest haemorrhage, often requiring surgical intervention [6,16]. Studies report that the occurrence of vomiting episodes shortly after food ingestion may suggest a possible obstruction in the gastric region, and anorexia or weight loss may be strong indicators of the development of GIT cancer. Symptoms related to strong upper abdominal pain that irradiate to the back indicate a possible penetration of the inflamed tissues to adjacent organs and severe and widespread pain can be associated with ulcer perforation [17,18].
How dyspepsia, gastroesophageal reflux symptoms, and overlapping symptoms affect quality of life, use of health care, and medication - a long-term population based cohort study
Published in Scandinavian Journal of Gastroenterology, 2021
Katrine Mie Klausen, Maria Bomme Høgh, Marc David, Ove B. Schaffalitzky de Muckadell, Jane Møller Hansen
The prevalence of gastroesophageal reflux symptoms (GERS) and dyspepsia in population studiesis relatively high [1–3]. The symptoms are often present at a young age, often persistand is therefore a frequent and recurring problem for individuals in the population [4,5]. GERS is defined as a condition that develops when stomach content reflux into the esophagus causing troublesome symptoms including heart burn, regurgitation, and retrosternal chest pain [6]. Dyspepsia refers to bothersome pain or discomfort in the upper abdomen including symptoms as abdominal bloating, nausea, and early satiety [7]. Different criteria are used to define GERS and dyspepsia in population-studies. For functional disease Rome criteria has been developed, and several validated questionnaires has been used. A recent meta-analysis has evaluated the influence of criteria used on the prevalence of GERS and dyspepsia and the overlap of these conditions [8]. This meta-analysis found the degree of overlap between GERS and dyspepsia that varied between 3.8% and 55.9%.