China
Africa
Explore chapters and articles related to this topic
Re-Highlighting the Potential Natural Resources for Treating or Managing the Ailments of Gastrointestinal Tract Origin
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Vaibhav Shende, Sameer A. Hedaoo, Mojabir Hussen Ansari, Pooja Bhomle, Debarshi Kar Mahapatra
Gastroesophageal reflux disease (GERD) is also known as heartburn or acid reflux. It occurs whilst the hoop of muscle fibers that surrounds the doorway to our stomach (known as the decrease esophageal sphincter) turns weak and acts as a substitute of ultimate tightly closed to save the backflow of food back up. Esophagus, it remains partially open, allowing partly digested meals and belly acid to leak lower back up the esophagus, inflicting irritation. The primary signs associated with GERD are regurgitation, heartburn, chest pain, and nausea.9
Fundoplication
Published in Mark Davenport, James D. Geiger, Nigel J. Hall, Steven S. Rothenberg, Operative Pediatric Surgery, 2020
Douglas C. Barnhart, Robert A. Cina
Gastroesophageal reflux is a physiologic event which is more common in infants than in adults. This normal physiological occurrence is distinguished from pathological reflux (gastroesophageal reflux disease, GERD) by both the intensity (frequency and duration of reflux episodes) and the complications which arise as a consequence of the reflux. Despite a growing body of literature addressing diagnostic testing and long-term outcomes, the precise indications for Nissen fundoplication in specific patient populations remains controversial. Consequently, there is significant variability in the use of Nissen fundoplication between children's hospitals. This is particularly true with regard to infants and children with neurological impairment. Even considering these areas of controversy, Nissen fundoplication remains an important operation in the pediatric surgeon's armamentarium as it can definitively control GERD and thereby improve the quality of life and decrease the rate of hospitalization in selected patients.
Obese Patient (BMI 32) with Reflux Disease and Diabetes Mellitus
Published in Savio George Barreto, Shailesh V. Shrikhande, Dilemmas in Abdominal Surgery, 2020
The routine use of gastroscopy in the preoperative bariatric patient also remains controversial. The authors believe that in an Roux-en-Y gastric bypass, where the distal stomach will no longer be accessible endoscopically, it seems prudent to exclude any pathology prior to surgery. Additionally, in the setting of long-standing symptoms of gastroesophageal reflux disease, it is important to exclude any associated complications, such as Barrett’s esophagus or peptic strictures. Gastroscopy is also useful to preoperatively identify the presence of a hiatal hernia that will need to be repaired at the time of surgery. The patient presented in our Case Scenario had a normal gastroscopy apart from mild reflux esophagitis.
“Comparison of Nissen Rossetti and Floppy Nissen techniques in laparoscopic reflux surgery”
Published in Annals of Medicine, 2023
Cem Kaan Parsak, İlker Halvacı, Uğur Topal
Laparoscopic fundoplication procedures have proven to be successful for the treatment of gastroesophageal reflux disease with low morbidity. As can be seen, gastrointestinal symptoms occur at various rates after laparoscopic surgery, and multiple theories have been put forward to explain the mechanisms behind their occurrence. There are different mechanisms behind the development of different symptoms, including vagal injury, tight fundoplication, the shift of the fundoplication into the thorax, dietary habits and air swallowing [21,38]. A previous study found postoperative symptoms to be more common when vagotomy was added to anti-reflux surgery [39], suggesting that vagal injury during laparoscopic anti-reflux surgery may lead to the development of gastrointestinal symptoms in the postoperative period. It is believed that postoperative adhesions may also be an effective factor delaying gastric and duodenal emptying, although these dyspeptic symptoms may also be related to an underlying undiagnosed disease. In such cases, the operation may not be the direct cause of the symptoms but may play a supporting role in their emergence. Nissen recommends care during surgery not to cause vagal injury [21,40].
Investigation of the potential relationship between gastroesophageal reflux disease and laryngopharyngeal reflux disease in symptomatology – a prospective study based on a multidisciplinary outpatient
Published in Scandinavian Journal of Gastroenterology, 2023
Xiaoyu Wang, Zhi Liu, Jinhong Zhang, Chun Zhang, Jing Zhao, Lianlian Liu, Shizhen Zou, Xin Ma, Jinrang Li
Gastroesophageal reflux disease (GERD) means symptoms or complications caused by the reflux of the gastric contents into the esophagus, mouth (including the larynx) or lungs, and its main typical symptoms include heartburn, regurgitation, belching, dysphagia, reflux cough, reflux chest pain and so on [1,2]. Laryngopharyngeal reflux disease (LPRD) is an infectious disease of the tissues of the upper aerodigestive tract caused by the direct or indirect effects associated with the reflux of gastroduodenal contents, which can cause morphological changes in the upper aerodigestive tract [3]. Common symptoms of LPRD include hoarseness, vocal fatigue, excessive throat clearing, globus pharyngeal, chronic cough, postnasal drip, dysphagia, etc. [4]. Common signs of LPRD include subglottic edema, ventricular obliteration, erythema/hyperemia, vocal fold edema, diffuse laryngeal edema, posterior commissure hypertrophy, granuloma/granulation tissue, excessive endolaryngeal mucus, etc. [5].
Esophageal chemical clearance and mucosa integrity values in refractory gastroesophageal reflux disease patients with different esophageal dynamics
Published in Scandinavian Journal of Gastroenterology, 2023
Yanqiu Li, Lixia Wang, Dong Yang, Zhifeng Zhang, Xiaoyu Sun, Xiaoling Geng, Jiarong Lin, Zhijun Duan
Gastroesophageal reflux disease (GERD) has become a common chronic gastrointestinal disease and increased the economic burden [1]. Many etiologies contribute to GERD, including reduced lower esophageal sphincter (LES) pressure, the abnormal esophagogastric junction (EGJ), decreased esophageal peristalsis, delayed gastric emptying and increased intraabdominal pressure [2]. These pathophysiological changes impact the structure and function of the anti-reflux barrier and esophageal clearance, cause reflex of gastroduodenal contents into the esophagus and break esophageal mucosa integrity [2]. At present, proton pump inhibitors (PPIs) are the best pharmacologic treatment option for GERD patients [3]. However, more than 30–40% of GERD patients still have persistent symptoms and the effect is not satisfying even though double doses of PPIs for 12 weeks, namely refractory GERD (RGERD) [3–7]. Therefore, identifying mechanisms and providing individual management for RGERD patients is particularly important.