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Benign tumours, moles, birthmarks and cysts
Published in Ronald Marks, Richard Motley, Common Skin Diseases, 2019
Syringoma lesions are multiple, small, white or skin-coloured papules that are typically seen in the skin below the eyes (Fig. 14.7) in young adults. Uncommonly, they are also evident on the arms and lower trunk. Histologically, there are tiny, comma-shaped epithelial structures, some of which appear cuticle lined, forming microcysts (Fig. 14.8).
Syringoma
Published in Longo Caterina, Diagnosing the Less Common Skin Tumors, 2019
Syringoma is a benign adnexal tumor deriving from intraepidermal eccrine ducts, which is usually found as multiple papules, ranging from 1 to 3 mm in diameter, on the lower eyelids and cheeks of young females.1 The papules are skin-colored or yellowish and generally asymptomatic. Solitary, giant, plaque-like, milia-like, linear unilateral and eruptive forms have also been reported, as well as location in other body areas, such as the genital area, skin folds and scalp.2–6 The clinical aspect of these uncommon variants has been reported to be similar to the classic form. Histopathologically, syringoma appears as a dermal tumor composed of a dense fibrous stroma in which multiple small ducts lined by two layers of cuboidal cells may be recognized; keratinous cysts may also be seen. In the clear cell variant of syringoma, the epithelial cells lining the ducts contain abundant glycogen and appear larger and paler. This variant is frequently associated with diabetes mellitus.7 The malignant form of syringoma is called syringomatous carcinoma, which is thought not to derive from the malignant degeneration of syringoma, but to originate as a malignant tumor ab initio. The differential diagnosis of syringoma is very wide and mainly related to body site and lesion number. Milia represent the most important differential diagnosis of the classic variant.1
Skin and soft tissue
Published in Tor Wo Chiu, Stone’s Plastic Surgery Facts, 2018
Syrinx is Greek for ‘pipe’ or ‘tube’, reflecting the characteristic appearance of convoluted ducts in the upper dermis. A syringoma is a benign tumour of eccrine sweat gland origin and is uncommon. They affect females more often with onset during adolescence.
Efficacy and safety of lasers in treating syringomas: a review of the literature
Published in Journal of Dermatological Treatment, 2022
Syringomas are benign adnexal neoplasms caused by an overgrowth of cells from sweat glands of eccrine origin (1). These lesions are small, multiple, asymptomatic, smooth, firm, skin-to-yellow-colored papules that frequently develop in clusters in a bilateral, symmetrical distribution (2). Based on clinical features and associations, Friedman and Butler classified syringomas as a localized form, a familial form, a type linked with Down syndrome, and a generalized form with numerous and eruptive syringomas (3). Syringomas are predominantly present around the periorbital region, especially the lower eyelids and are less prevalent on the forehead, scalp, cheeks, abdomen, extremities, axilla, buttocks, and genitalia (4). Although the appearance of syringomas is most frequent in the third and fourth decades of life, studies have also shown that they can occur in any age group before or after puberty (5). Syringomas are more common in women (6) and patients with Down syndrome (7). The female preponderance may be explained by the influence of hormones. The racial predilection for syringoma is not widely reported. However, eruptive syringomas are thought to be more common in African Americans and Asians (8). The mechanism for the formation of the lesions in syringoma is largely unknown. Clinical presentation of eruptive syringomas can be confused with acne vulgaris, milia, sebaceous hyperplasia, lichen planus, urticaria pigmentosa, hidrocystoma, and eruptive xanthoma on the face. Further, syringomas on the face may resemble sclerosing basal cell carcinoma and desmoplastic trichoepithelioma, while lesions on the eyelids may resemble xanthelasma. Syringomas have specific histopathological features, hence histological investigation can be used to provide a definitive diagnosis (2).
An unusual presentation of eruptive syringomas on the neck
Published in Baylor University Medical Center Proceedings, 2021
Madeline R. Frizzell, Saadeddine S. Saad, Katherine H. Fiala
Syringomas are benign adnexal tumors derived from the intraepidermal portion of eccrine sweat ducts and present as soft, flesh-colored to slightly yellow dermal papules.3 They have a predilection for the lower eyelids, cheeks, axillae, neck, and abdomen and predominantly occur in women at puberty and in patients with Down syndrome.3 Although patients with syringomas present at a mean age of 29 years,3 studies examining patients with eruptive syringomas show presentation between 4 and 10 years of age, similar to our patient.4
Uses of eye drops in dermatology, literature review
Published in Journal of Dermatological Treatment, 2022
Sameh Magdy Sarsik, Heba Saed El-Amawy
Syringomas are eccrine tumors that are prevalent. Multiple small flesh-colored slightly yellow to brownish cutaneous papules (82), frequently on the periorbital area and neck, but can also present on the axillae, abdomen, and extremities (83). Syringoma has an uncertain course, and while it may spontaneously resolve, treatment for syringoma is primarily for cosmetic reasons.