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Malignant tumors
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Sebaceous carcinoma is a malignant neoplasm with sebocytic differentiation. There is one report of a sebaceous gland carcinoma of the lateral aspect of the right index finger in a 46-year-old man. It presented as a painless swelling without bony alterations on X-ray. The excision was carried out under the clinical diagnosis of an epidermoid cyst and showed an irregular, well-circumscribed lesion with a pseudocapsule. The lesion was treated by amputation.87
Benign and Malignant Conditions of the Skin
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Murtaza Khan, Agustin Martin-Clavijo
Sebaceous carcinoma (SC) arises from the sebaceous glands. They most commonly affect the head and neck, with the eyelids reported as being the most common site. It is more common in older patients. It has been associated with Muir-Torres syndrome and Lynch syndrome so all patients with SC should be assessed for this.
Tumors of Cutaneous Appendages
Published in Omar P. Sangueza, Sara Moradi Tuchayi, Parisa Mansoori, Saleha A. Aldawsari, Amir Al-Dabagh, Amany A. Fathaddin, Steven R. Feldman, Dermatopathology Primer of Cutaneous Tumors, 2015
Sebaceous carcinoma: Usually large, asymmetric, poorly circumscribedAbundant necrosis (necrosis en masse)Nuclear atypia often strikingNumerous and sometimes abnormal mitotic figures
A rare concurrence of Muir-Torre-associated sebaceous carcinoma in the setting of a lipedematous scalp
Published in Case Reports in Plastic Surgery and Hand Surgery, 2020
Allison Shanks, Jake Laun, Amanda Holstein, Saksham Varshney, Jane Messina, Carl Wayne Cruse
Clinical presentations of sebaceous carcinomas are varied, and it is known for masquerading as common benign conditions. In a study of 31 patients with extraocular sebaceous carcinoma, the most common presentations were blepharoconjunctivitis (32%), eyelid masses (29%), or eyelid thickening (26%), with regional lymphadenopathy accounting for 3% of initial presentations [14]. Extraocular sebaceous carcinomas usually present similarly to benign skin conditions like pyoderma gangrenosum or molluscum contagiosium as well as to malignant skin lesions like squamous cell carcinoma or basal cell carcinoma [15]. Due to the variety of clinical presentations, sebaceous carcinoma is frequently misdiagnosed. These misdiagnoses lead to delay in treatment and increased risk of local recurrence, metastasis, and poor outcomes.
Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid — a population-based analysis
Published in Orbit, 2019
Sebaceous carcinoma (SC), also commonly known as sebaceous gland carcinoma or sebaceous adenocarcinoma, is a cutaneous malignancy that may occurs in the periorbital area, namely the eyelid.1 While the Meibomian glands and the glands of Zeis are two of the most common cellular origins for SC, it may also arise from the caruncle and pilosebaceous apparatus of eyebrow hair follicles.2 SC is considered a rare tumor, constituting only 2.8% of neoplasms invading the orbit, making it the third most common eyelid malignancy after basal cell carcinoma and squamous cell carcinoma.3–5 While SC can be locally invasive within the eyelid and conjunctiva, it may also metastasize to regional lymph nodes as well as other distant sites at presentation.1,6
Misdiagnosis of sebaceous carcinoma
Published in Acta Chirurgica Belgica, 2022
Gino Vissers, Jérôme Corthouts, Carole Van Haverbeke, Sabine Declercq, Marianne Mertens
Sebaceous carcinoma is a rare malignant tumour of the sebaceous glands. It can occur at any body site, but as the periocular area has a high density of sebaceous glands, approximately 40% of all sebaceous glands arise in this specific area. It often affects the elderly population, with a mean age of 70 years [1]. Clinical presentation may begin as a painless lump or as a thickening of skin on the upper eyelid. This can be accompanied by secondary inflammatory features, thereby mimicking benign conditions such as a chalazion or keratoconjunctivitis. Diagnosis is made by biopsy and treatment usually involves oncologic resection and primary reconstruction for early-stage lesions. However, as the tumour grows and invades surrounding areas, it may become complex to treat.