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Chronic erythematous rash and lesions on trunk and limbs
Published in Richard Ashton, Barbara Leppard, Differential Diagnosis in Dermatology, 2021
Richard Ashton, Barbara Leppard
With blistering, exudate or erosionsLinear contact dermatitis from external agents: – phytophotodermatitis due to sunlight and plant sap brushed onto the skin (p. 133).– allergic contact dermatitis due to plant sap (p. 133).– Berloque dermatitis due to sunlight and psoralen (from cosmetics) in contact with skin.Dermatitis artefacta – self-inflicted (p. 185).
Cutaneous Phototoxicity
Published in Henry W. Lim, Nicholas A. Soter, Clinical Photomedicine, 2018
In phytophotodermatitis, the psoralen phototoxic reaction manifests initially as a burning erythema that eventually resolves leaving areas of hyperpigmentation. When the reaction is particularly severe, the erythema may progress to form bullae. In other instances, the erythema is mild and may even go unnoticed. These patients often present with a pigmentary disorder. The hyperpigmented areas may persist for several months. A unique feature of phytophotodermatitis is its distribution. In those individuals who brush up against psoralen-containing grasses and plants, this often takes on a linear distribution (Fig. 2). In celery handlers and in bartenders, the eruption is frequently localized to the hands.
Systemic and Topical PUVA Therapy
Published in John Y. M. Koo, Ethan C. Levin, Argentina Leon, Jashin J. Wu, Alice B. Gottlieb, Moderate to Severe Psoriasis, 2014
Warwick L. Morison, Elisabeth G. Richard
Pharmacology Psoralens occur naturally in a large number of plants and are responsible for inducing phytophotodermatitis, which is simply a phototoxic reaction in the skin. Several psoralens are used in PUVA therapy, but only methoxsalen (8-methoxypsoralen) is approved for use in treating psoriasis in the United States. Bergapten (5-methoxypsoralen) is available for treatment in Europe.
Sunlight radiation as a villain and hero: 60 years of illuminating research
Published in International Journal of Radiation Biology, 2019
Julia Montelin Powers, James Edward John Murphy
Skin contact with the sap of certain plants causes phytophotodermatitis, a condition in which a toxin in the sap, often a furanocoumarin, interacts with DNA in the skin when activated by ultraviolet light (Zajdela and Bisagni 1981), causing cell death. Typically this presents as erythema and often severe blistering, which can persist for days, with hyperpigmentation persisting for months in some cases (Smith et al. 2012). Two of the more common families of plants containing furanocoumarins are the Umbelliferae including hogweeds, parsnips and celery, and the Rutaceae or citrus family (Pathak et al. 1963).
Phytodermatitis in East and southeast of Turkey: A prospective study
Published in Cutaneous and Ocular Toxicology, 2019
Phytodermatitis is classified as phytophotodermatitis (PPD), irritant contact dermatitis (ICD), and allergic contact dermatitis (ACD). PPD is a type of phototoxic dermatitis due to psoralene, a photosensitive substance found in plants3. ICD is developing after unintended contact with the plant or due to the use of some plants as an alternative treatment method. This reaction develops due to substances such as ranunculin, mandragorine, triterpenoids, guaianolides, malvin, and polyphenols found in plants1,4–7.