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Naturopathic Medicine and the Prevention and Treatment of Cardiovascular Disease
Published in Stephen T. Sinatra, Mark C. Houston, Nutritional and Integrative Strategies in Cardiovascular Medicine, 2022
Celery is another particularly interesting food for lowering blood pressure. A celery seed extract standardized to contain 85% 3-n-butylphthalide (3nB) has been shown to help improve blood pressure control. 3nB is a compound that is unique to celery and is responsible for the characteristic flavor and odor of celery. It was discovered as the active component of celery in response to investigations by researchers seeking to explain some of the traditional effects of celery, including lowering of blood pressure and relief of joint pain. The dosage of the extract is 75–150 mg twice daily. This amount would translate to about 12 ribs of celery, probably too high of an amount of whole celery to eat, but easily done by juicing.49
Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
In traditional medicine, celery has been used to treat spasm and stomach problems and as a diuretic, laxative, and sedative. It is also used to lower blood pressure and to treat inflammation (arthritis, gout), muscle spasms, and joint problems (134–136). Pharmacologically, celery leaves, stems and seeds exerted antioxidant, anti-inflammatory, gastrointestinal, cardiovascular, cytotoxic, antimicrobial, anti-helminthic, hypolipidemic, and central nervous effects. Celery may prevent hypercholesterolemia and some cancer forms (134–136). However, no official documents have yet recognized these therapeutic effects in humans. A few animal studies suggest that celery and its seed extract may help lower blood pressure and cholesterol, as well as reduce pain. Celery and its seed can cause a severe allergic reaction called anaphylaxis, which can be fatal for some people (136). Avoid celery and its seed for pregnant women and hypersensitive people. Take note that it can also interfere with some drugs (anticoagulants, thyroid medications, lithium, and sedatives).
Tropical Herbs and Spices as Functional Foods with Antidiabetic Activities
Published in Megh R. Goyal, Arijit Nath, Rasul Hafiz Ansar Suleria, Plant-Based Functional Foods and Phytochemicals, 2021
Arnia Sari Mukaromah, Fitria Susilowati
Celery contains alkaloids, carbohydrates, flavonoids (apigenin, apiin, isoquercitrin), glycosides, steroids, vitamin A and vitamin C [4, 53]. Other phytochemical compounds in celery leaves are: apigenin, bergapten, chry-soeriol 7-glucosides, furanocoumarin, luteolin, isopimpinellin, phenols, phthalide, psoralen, and xanthotoxin [18, 53]. Celery has also been documented to have several hypoglycemic compounds (such as, essential oils, flavonoids (kaempferol, quercetin, triterpenes, and luteolin), phenolics, triterpenes with antidiabetic [37] antioxidant properties.
An Overview of Hepatocellular Carcinoma with Emphasis on Dietary Products and Herbal Remedies
Published in Nutrition and Cancer, 2022
Deepa S. Mandlik, Satish K. Mandlik
Celery (Apium graveolens L.) is a common vegetable all over the world. Its seeds are traditionally used to treat liver disorders because of their potent antioxidant and anti-inflammatory properties. Apigenin, linamarose, and vitamins A and C were found to be the most bioactive constituents in celery seeds, according to a phytochemical study. Chemically induced hepatocarcinogenesis was inhibited in rats pretreated with celery seed extracts, as demonstrated by a decrease in γ-GT positive foci (67). The cytotoxicity of mung bean sprouts (MBS) extract on HepG2 cells and normal human cells were different. Stimulation of apoptosis (Bax and caspase-8), the rise of anti-tumor cytokines (TNF-α and IFN-β), the elevation of IFN-γ development, and enhancement of cell-mediated immunity were among the mechanisms underlying MBS anti-tumor properties (68). The leaves of Perilla frutescens L. are eaten as a vegetable and are commonly used for their sweet fragrance. The extracts obtained of several plants, such as caffeic acid, rosmarinic acid and apigenin have been shown to have anti-proliferative properties against a variety of cancers. According to one study, isoegomaketone extracted from P. frutescens, repressed cell progression and xenograft tumor development in HCC cells, most likely by blocking the PI3K/Akt signaling pathway (69).
Fractionation and bioassay-guided isolation of antihypertensive components of Senecio serratuloides
Published in Cogent Medicine, 2020
Charlotte Mungho Tata, Derek Ndinteh, Benedicta Ngwenchi Nkeh-Chungag, Opeopluwa Oyehan Oyedeji, Constance Rufaro Sewani-Rusike
The high phytochemical content of SSEA and SSMOH was reflected in their antioxidant and antihypertensive capacities. Phytochemicals such as sterol, flavonoid, saponin, tannin, phenol, alkaloid and cardiac glycoside have been proven to have antioxidant activity (Bajpai et al., 2016; Biancardi et al., 2007). The mechanisms of action of these antioxidants include suppressing reactive oxygen species formation either by inhibition of enzymes or chelating trace elements involved in free radical production; scavenging reactive oxygen species; up-regulating or protecting antioxidant defences (Kumar & Pandey, 2013). The high antioxidant capacity of SSEA and SSMOH was reflected in their better antihypertensive properties. Their efficacy against acute L-NAME induced HTN suggested that they may have vasoactive properties. Previous studies have indicated the possibility of plant extracts in acting as vasorelaxants, for instance; extracts of saffron have been shown to decrease contractility and heart rate of guinea-pig isolated perfuse hearts by blocking Ca2+ channels, opening potassium channels and antagonizing β-adrenoreceptors (Boskabady, Shafei, Shakiba, & Sefidi, 2008). Extracts and constituents of celery have also been reported to lower arterial pressure in humans, possibly by lowering levels of circulating catecholamines and decreasing vascular resistance (Houston, 2005). The mechanism of action of extract components with vasoactive properties may be similar to that of neurotransmitters which modulate the activities of receptors directly by binding to the relevant receptor proteins or indirectly by diffusing into postsynaptic membranes and altering the membrane physicochemical properties (Kumar & Pandey, 2013; Tapas, Sakarkar, & Kakde, 2008). Besides interacting with functional proteins (enzymes, receptors, and ion channels) as the primary targets, bioactive phytochemicals like flavonoids, terpenoids, alkaloids have been presumed to act on lipid bilayers and modify membrane physicochemical properties (Tsuchiya, 2015).
Assessment of Antihyperlipidemic and Antitumor Effect of Isolated Active Phytoconstituents from Apium graveolens L. through Bioassay-Guided Procedures
Published in Journal of Dietary Supplements, 2019
Apium graveolens L. (Apiaceae) is commonly known as celery. In India, celery is used as Ayurvedic or traditional medicine to relieve flu, colds, poor digestion, water retention, disorders of the spleen and liver, and different types of arthritis.