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Role of Medicinal Plants in the Treatment of Hemorrhoids
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Yaw Duah Boakye, Daniel Obeng Mensah, Eugene Kusi Agyei, Richard Agyen, Christian Agyare
The major phytochemicals in Cissus quadrangularis are flavonoids. Bioflavonoids have been shown to exhibit phelotonic, vasculoprotective, and anti-inflammatory activities. Luteolin and ß-sitosterol from the crude extract of C. quadrangularis have been shown to produce its anti-inflammatorry effect. The venotonic effect of C. quadrangularis has been postulated to be due to the flavonoids present in its crude extract, which act in the same way as that of diosmin and hesperidin (found in Daflon).53
Pharmacology for venous and lymphatic diseases
Published in Ken Myers, Paul Hannah, Marcus Cremonese, Lourens Bester, Phil Bekhor, Attilio Cavezzi, Marianne de Maeseneer, Greg Goodman, David Jenkins, Herman Lee, Adrian Lim, David Mitchell, Nick Morrison, Andrew Nicolaides, Hugo Partsch, Tony Penington, Neil Piller, Stefania Roberts, Greg Seeley, Paul Thibault, Steve Yelland, Manual of Venous and Lymphatic Diseases, 2017
Ken Myers, Paul Hannah, Marcus Cremonese, Lourens Bester, Phil Bekhor, Attilio Cavezzi, Marianne de Maeseneer, Greg Goodman, David Jenkins, Herman Lee, Adrian Lim, David Mitchell, Nick Morrison, Andrew Nicolaides, Hugo Partsch, Tony Penington, Neil Piller, Stefania Roberts, Greg Seeley, Paul Thibault, Steve Yelland
Daflon or micronized purified flavonoid fraction (MPFF 90% diosmine and 10% other flavonoids expressed as hesperidin) is indicated for symptom relief and may also have possible benefit for healing ulcers. It acts to decrease leukocyte activation by inhibiting expression of endothelial intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule (VCAM), as well as surface expression of some leucocyte adhesion molecules. It affects platelet function, inhibits noradrenaline degradation and enhances lymphatic peristalsis to increase lymph flow.
Drug treatment of varicose veins, venous edema, and ulcers
Published in Peter Gloviczki, Michael C. Dalsing, Bo Eklöf, Fedor Lurie, Thomas W. Wakefield, Monika L. Gloviczki, Handbook of Venous and Lymphatic Disorders, 2017
This combination of flavonoid drugs has been used to manage the symptoms of chronic venous disease, including edema of the lower limbs, for many years. The use of this application has been summarized above. More recently, a number of clinical trials has been completed in which one flavonoid drug was used to treat patients with venous leg ulcers. Micronized purified flavonoid fraction (MPFF; Daflon 500 mg®, Servier, Gidy, France), which consists of 90% Diosmin and 10% flavonoids expressed as Hesperidin, has been shown to protect the microcirculation from damage secondary to raised ambulatory venous pressure.38 It decreases the interaction between leukocytes and endothelial cells by inhibiting expression of endothelial intercellular adhesion molecule 1 and vascular cell adhesion molecule, as well as the surface expression of some leukocyte adhesion molecules (monocyte or neutrophil CD62L and CD11B).39 There are few known side effects, and interactions with other drugs have not been reported.38
Recommendations and best practice on the management of hemorrhoidal disease in Saudi Arabia
Published in Hospital Practice, 2022
Mohamed Zaki El-Kelani, Raouf Kerdahi, Samir Raghib, Mohamed Ashraf Shawkat, Naser Abdelnazer, Ishag Mudawi, Magdy Mahmoud, Wassim Abi Hussein, Mohamed Tawfik, Waleed Wahdan
Lifestyle modifications (same as above).Avoiding constipation.Using MPFF (e.g., Daflon 500 mg) to decrease pain and recurrence.Using combined analgesia for 5 days of paracetamol, non-steroidal anti-inflammatory drugs, and opioids.Using laxatives to ensure a soft and regular bowel movement.Post-operative rehabilitation for wound healing and improving the quality of life of patients with defecation problems [25], starting with patient reeducation on muscular synergy (chest, abdomen, vertebral column, and perineum) [26].
Comparison of the effects of methylprednisolone, hyperbaric oxygen and hesperidin + diosmin on the facial nerve injury: an experimental animal model
Published in Acta Oto-Laryngologica, 2023
Yaşar Özbuğday, Mehmet Erkan Kahraman, Abdullah Arslan, Ilknur Küçükosmanoğlu
The rats in the first and second groups were followed for three weeks without treatment. The rats in the third group were applied everyday 1 mg/kg/day methylprednisolone (Prednol-L 20 mg, Mustafa Nevzat İlaç Sanayi A.Ş., Istanbul, Turkey) intraperitoneally, starting a day after the surgery. To the rats in the fifth group, were applied everyday 100 mg/kg/day HD (Daflon 500 mg tablet, Abdi İbrahim İlaç Sanayi ve Ticaret A.Ş., Istanbul, Turkey) fraction by oral gavage, starting a day after the surgery. The HD fraction was crushed and dissolved in distilled water, then a homogeneous mixture was obtained with the help of a special mixer (Bio vortex V1, Biosan). All solutions were prepared fresh daily before administration to the animals.
Results of purified micronized flavonoid fraction in the treatment of categorized type III chronic pelvic pain syndrome: a randomized controlled trial
Published in The Aging Male, 2020
Aytac Sahin, Musab Ali Kutluhan, Caglar Yildirim, Ahmet Urkmez, Serkan Akan, Ayhan Verit
On the other hand, it is known that only the use of alpha-blockers, antibiotics, and anti-inflammatory drugs are highlighted in the European Association of Urology guidelines [25]. Similarly, in our study, the group receiving antibiotic + anti-inflammatory + alpha-blocker responded to treatment better than that receiving daflon treatment alone.