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The vascular risk factors of ischemic stroke in young adults
Published in Ade Gafar Abdullah, Isma Widiaty, Cep Ubad Abdullah, Medical Technology and Environmental Health, 2020
A. Tursina, R.A. Indrianti, W. Nurruhyuliawati
This happens because cholesterol levels in normal circumstances increase in young adults at an average of 200 mg. Hypercholesterolemia is a disease that is chronic or prolonged while hypocholesterolemia in young adults is less frequent. Patients who have a history of hypercholesterolemia suffer from stroke because their cholesterol levels increase due to their unhealthy lifestyle choices such as consuming foods high in cholesterol and saturated fat. High cholesterol levels can cause atherosclerosis, which results in narrowing of the walls of blood vessels, disrupting the blood supply to the brain. This is what will cause strokes (Alchuriyah & Wahjuni 2016; Burhanuddin 2013; Eshak et al. 2017; Sitorus 2008; Syifa et al. 2017).
Antidiabetic Potential of Medicinal Mushrooms
Published in Hafiz Ansar Rasul Suleria, Megh R. Goyal, Masood Sadiq Butt, Phytochemicals from Medicinal Plants, 2019
Vivek K. Chaturvedi, Sushil K. Dubey, M.P. Singh
Fruiting body of A. bisporus was fed to the STZ-induced diabetic mice, showing significant hypoglycemic and hypocholesterolemic activities.47 Hypercholesterolemia can be a reason for the progression of type 2 diabetes/hyperglycemia in human. β-Cell metabolism can be affected directly by cholesterol, which leads to dysfunctioning of β cells and causes diabetes.35 Dietary fibers have a defensive activity to the β cells and have shown potent antidiabetic effect. At high intake, it shows effective hypocholesterolemic effect.7
Malformations of the Lymphatic System
Published in Waldemar L. Olszewski, Lymph Stasis: Pathophysiology, Diagnosis and Treatment, 2019
In earlier times, one would have diagnosed this case as “elephantiasis after chronically recurrent erysipelas”. Because of the unusual lymphectasias and a strikingly large hypo-proteinemia and hypocholesterolemia, a further investigation was undertaken. Two operations had already been carried out in 1959 because of lymphangioma circumscriptum or lymphatic cysts on the legs, and twelve attacks of erysipelas followed.
Prognostic Significance of the Preoperative Controlled Nutritional Status Score in Lung Cancer Patients Undergoing Surgical Resection
Published in Nutrition and Cancer, 2021
Jingjing Shao, Jing Li, Xun Lei Zhang, Gaoren Wang
Cholesterol metabolism is abnormal in malignant tumor cells, including prostate cancer, lung cancer, acute myeloid leukemia, breast cancer, and other tumors. Tumor cell proliferation may require new membrane synthesis. Cholesterol was higher in tumor tissues than in normal tissues. Cholesterol was related to cell proliferation, and cholesterol provides favorable conditions for cell growth. Cholesterol oxidase can increase the content of ROS by reducing cholesterol levels, which leads to cell apoptosis. Based on previous research, HDL-C played an active role in cancer development (19). Low serum cholesterol levels were related to the poor prognosis of patients with malignant tumors, such as colorectal cancer, kidney cancer, and pancreatic cancer. In addition, hypocholesterolemia can cause systemic inflammation and cancer. CONUT score includes immune defense, calorie consumption, and protein savings. Therefore, the CONUT score can reflect the immune and nutritional status.
Evidence of metabolic imbalance and oxidative stress among patients suffering from pressure ulcers
Published in Journal of Dermatological Treatment, 2019
Latifa Khlifi, Hajer Graiet, Sondes Sahli, Manel Ben-Hadj-Mohamed, Souhir Khelil, Nadia Bouzidi, Abed Elhedi Miled
Interestingly, hypocholesterolemia was observed extensively in our PU patients compared to the controls. Hypocholesterolemia may be caused by diverse causes, such as body composition, environmental factors, physical activity, and malnutrition, and may be linked to the presence of total lipid levels in the upper limit of the normal range. Although TGs were not considered important factors of cardiovascular risk in the past, nowadays, they are believed to be capable of interfering with survival because of their hemorheologic and thrombotic implications. However, TGs alone have a minor role in predicting cardiovascular risk. Measuring HDL-C seems to be the better option to solve this. Patients with PU show increased cardiovascular risk and may be more disposed to atherosclerosis than healthy subjects (35). In our research, the atherogenic link between high TG and low HDL-C levels may be due to the higher concentration of TG-rich VLDL, which generates small, dense LDL during lipid exchange and lipolysis. These LDL particles are accumulated in the circulatory system and form small, dense HDL particles, which undergo accelerated catabolism, consequently, the close the atherogenic circle (36). Recently, non-HDL-C has become increasingly recognized as an important measure of atherogenic particles, as it reflects the CT in all lipoprotein particles. A high value of non-HDL-C has been strongly associated with predicting CAD (37). In our study, non-HDL-C levels were found to be higher in patients with PU as compared to healthy controls which suggest an increased risk of cardiovascular diseases (CVD).
Lessons from chylomicron retention disease: a potential new approach for the treatment of hypercholesterolemia?
Published in Expert Opinion on Orphan Drugs, 2018
In conclusion, this very rare disease inducing a severe hypocholesterolemia could be a model to develop new therapeutic approaches for hypercholesterolemias, which are common diseases and important in terms of public health. Previously, the understanding of pathophysiology of other genetic hypocholesterolemias, namely ABL and FHBL, led to the development of inhibitors of microsomal transfer protein (MTP) and of apoB, respectively, with powerful effects [15]. Inhibitors of SAR1b-dependent transport could be new tools to treat hypercholesterolemia. The large diversity of molecules transported through this pathway, and the risk of hepatic or muscular consequences appear to be the main problems in developing such therapies. Therefore, molecules specific to the enterocytes should probably be developed to reduce the risk of side effects.