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Hydrogel Nanocomposites as an Advanced Material
Published in Vineet Kumar, Praveen Guleria, Nandita Dasgupta, Shivendu Ranjan, Functionalized Nanomaterials II, 2021
Ankur H. Gor, Pragnesh N. Dave
Nanocomposite hydrogels are a new strategic product, which have a structured network and contain nanoparticles with other additives. In the last decade, varieties of nanocomposites have been applied in the pharmaceutical and biomedical fields. The broad application range of nanocomposite hydrogels is due to their biodegradable and biocompatible characteristics. Nanocomposite hydrogels are known as sustainable drug delivery agents because they allow the release of a drug at a specific site and in a reduced sustainable manner (Hamidi et al. 2008). Nanocomposites could be a suitable vehicle for the load and transportation of a biologically active component. There are many aspects such as the component of nanocomposite hydrogel, and the swelling ratio that has an effect on the release of the biological active molecule. Nanocomposite hydrogels are able to deliver local drug delivery and stimuli-responsive drug delivery.
Introduction to Green Molecules, to the Present Situation and to Previous Research on Green Polymer Nanocomposites
Published in Satya Eswari Jujjavarapu, Krishna Mohan Poluri, Green Polymeric Nanocomposites, 2020
Another area of exploration of nanocomposites which are commonly used in drug delivery systems and tissue engineering is that of nanocomposite hydrogels. Hydrogels are porous network structures with swelling/dwelling behavior, cell adhesion and excellent biocompatibility but lacking in mechanical properties and multifunctionality. Biosynthesis of hydrogels from naturally abundant polymer (cellulose and chitin), their properties and applications were reviewed in Shen, Shamshina, Berton, Gurau, & Rogers (2015). By combining hydrogels with various organic and inorganic nanofillers, there is improvement in their properties, such as mechanical strength, tunable cell adhesion, biodegradability and self-healing (Song, Li, Wang, Liao, & Zhang, 2015). Recently, hydrogels were prepared using natural polymers (guar gum) to increase their water retention properties for agricultural application (Abdel-Raouf, El-Saeed, Zaki, & Al-Sabagh, 2018). A green synthesis of hydrogel was achieved even with bacterial cellulose derived from acetic acid bacteria, where the water retention of hydrogel was shown to be dependent on the total solid content of bacterial cellulose (Chaiyasat et al., 2018).
Nanotechnology in Cell Delivery Systems
Published in Klaus D. Sattler, st Century Nanoscience – A Handbook, 2020
Ali Golchin, Parisa Kangari, Sepideh Mousazadehe, Faeza Moradi, Simzar Hosseinzadeh
Nanocomposite hydrogels are hybrid hydrogels that are either nanoscale copolymer network or cross-linked with NPs or nanostructures. Nanocomposite hydrogels can be based on NPs such as carbon-based nanomaterial (e.g. CNTs), polymeric NPs (e.g. dendrimers), inorganic/ceramic NPs (hydroxyapatite) and metal/metal-oxide NPs (gold) (Gaharwar et al. 2014). Nanocomposite hydrogels due to high surface interactions between the NPs and the polymer chains are applicable in biomedical area. In these hydrogels, due to the combination of multiple phases and different properties, incorporation obtained suitable matrix mimicking native ECM (Wang et al. 2010).
PVA nanocomposite hydrogel loaded with silver nanoparticles enriched Nigella sativa oil
Published in Inorganic and Nano-Metal Chemistry, 2022
Eram Sharmin, Afnan S. Batubara, Bushra Abdulrahman Tamboosi, Elaf Bander Al Khozay, Maha Khalid Alamoudi, Ohoud Zaki Al Aidaroos, Jana Abdullaziz Albenayan, Majd Yousuf Lamfon, Afnan Abdulhamaid Hassan Sindi, Lamiaa A. Al-Madboly, Nagwa A. Shoeib, Manawwer Alam
Hydrogels are smart hydrophilic polymers with three dimensional cross-linked networks. They can retain large volumes of water in their swollen structures when placed in water, and are responsive to external stimuli such as pH, temperature, ionic strength and electric field. Hydrogels’ classification is based on their source (natural or synthetic), configuration, type of cross-linking (chemical or physical nature of the cross-link junctions), physical appearance, methods of preparation, and network electrical charge. Hydrogels find applications in antimicrobial packaging, drug delivery, wound dressings and several other biomedical and pharmaceutical applications. Often, conventional hydrogels bear inferior properties and lack functionalities required for their targeted applications. Thus, hydrogel matrices are loaded with NP as nano fillers/nano reinforcements (e.g., nanoclays, carbon nanotubes, hydroxyapatite, silica, calcium, silver, gold, titania, alumina, and others), producing nanocomposite hydrogels with improved physical, chemical, and biological properties relative to conventional hydrogels, correlated to enhanced interactions between polymer hydrogel backbone/chains and the introduced NP, with promising applications in metal adsorption, sensors, drug delivery, and other biomedical devices.[15–19]
One-pot synthesis of magnetic chitosan/iron oxide bio-nanocomposite hydrogel beads as drug delivery systems
Published in Soft Materials, 2021
S. Barkhordari, A. Alizadeh, M. Yadollahi, H. Namazi
Recently, there has been a great interest to generate organic-inorganic nanocomposite hydrogels through their superior biomedical relevance. Many nanocomposite hydrogels are found proper to be used as drug delivery carriers because they frequently, exhibit remarkably improved properties compared with the pure polymer hydrogels. The introduction of nanoparticles can reduce the burst drug release effect, increase the stability of drug and provide a slower and more continuous release mode of drugs .[9,10,11,12] There are several reports about the drug release behavior from the chitosan nanocomposites with different inorganic particles like montmorillonite, [13] hydroxyapatite, [14] silver, [15] zinc oxide, [16] copper oxide, [17] etc.
Capecitabine-loaded anti-cancer nanocomposite hydrogel drug delivery systems: in vitro and in vivo efficacy against the 4T1 murine breast cancer cells
Published in Journal of Biomaterials Science, Polymer Edition, 2020
Nastaran Taleblou, Mohammad Sirousazar, Zuhair Muhammad Hassan, Sahar Ghaffari Khaligh
Hydrogels are three-dimensional hydrophilic networks consisted of cross-linked polymer chains that can absorb and retain a significant amount of water or physiological solutions without dissolving [11, 12]. They are natural or synthetic substances which, due to their high water content, are soft materials owing a high degree of flexibility. In spite of excellent performance in practical applications, hydrogels show restricted usages in some cases. Because of their weak mechanical properties, for instance, low gel strength, poor stability and low fracture toughness, especially in the swollen state, the application of hydrogels is restricted [13]. Since 2002, nanoparticles or nanostructures, such as clay nanolayers, have been utilized in the production of polymeric hydrogels and a new kind of hydrogels, so-called nanocomposite hydrogels, with improved physical, chemical, mechanical, thermal and structural properties, have been introduced [14]. Nanocomposite hydrogels are defined as three-dimensional hydrophilic structures that include at least one polymer-based hydrogel matrix and a reinforcing agent in nanosized dimensions [15]. In most cases, nanostructures act like cross-linking points and increase the cross-linking density and gelation properties in nanocomposite hydrogels. Nanoparticles increase the interaction between themselves and the polymeric chains, which improves the physical and mechanical properties of nanocomposite hydrogels [16].