China
Africa
Explore chapters and articles related to this topic
Nanostructured Biomaterials for Load-Bearing Applications
Published in Ashwani Kumar, Mangey Ram, Yogesh Kumar Singla, Advanced Materials for Biomechanical Applications, 2022
Tissue engineering and regenerative medicine aim to repair tissue and/or regeneration with the help of stem cells, scaffolds, growth and signaling factors. Tissue engineering serves as the alternate way to resolve orthopedic-related problems by reducing the limitations of traditional interventional methods. The effective ways of accomplishing tissue engineering include cell-based therapies, scaffold material implementation, growth factors and bioactive molecules delivery. The notable features of the materials to be used in scaffolds are biocompatibility, bioresorbability, mechanical properties and porosity.
Polysaccharides and Proteins-based Hydrogels for Tissue Engineering Applications
Published in Rajesh K. Kesharwani, Raj K. Keservani, Anil K. Sharma, Tissue Engineering, 2022
Roberta Cassano, Federica Curcio, Maria Luisa Di Gioia, Debora Procopio, Sonia Trombino
The design and application of biomaterials in tissue engineering have made great strides in the last years with extraordinary impact in various clinical applications. In particular, the development of new materials, of natural origin, has made it possible to improve the performance of the scaffolds, positively conditioning both the biological response, and the speed and quality of a new tissue proliferation. Therefore, in this chapter, various and interesting approaches, based on protein and carbohydrate hydrogels, are described, suggesting a very promising future for their application in tissue engineering.
Bioresponsive Hydrogels for Controlled Drug Delivery
Published in Deepa H. Patel, Bioresponsive Polymers, 2020
Tamgue Serges William, Dipali Talele, Deepa H. Patel
The main purpose of tissue engineering is to regenerate living, healthy, and functional tissues that can be employed as tissues graft or organ replacement. The general approach is to utilize 3D scaffolds that function as temporary supports for cell growth and new tissue development. Hydrogels with their crosslink network and other mechanical properties are ideal candidates to make scaffold for tissue engineering. There are various approaches to successfully engineer tissues or organs; however, the most employed strategy involves is based on the combination of patient’s own cells with the polymer scaffold. These strategies involve the isolation of cells from patient’s tissue by a small biopsy of the desired tissue’s cells followed by the harvesting in vitro. Then the cells are incorporated in the 3D polymer scaffold where it acts as the natural ECM. The combined cells with the scaffold are introduced in the body, and the scaffold will deliver the cells to the desired site, it will provide a space for a new tissue formation, and will probably control the structure and function of the engineered tissue [32].
Development of a novel poly (lactic-co-glycolic acid) based composite scaffold for bone tissue engineering
Published in Inorganic and Nano-Metal Chemistry, 2022
Mojtaba Ansari, Hossein Eslami
Tissue engineering is an interdisciplinary field combining the science and technology of biology and chemistry to yield promising alternatives for the treatment of the loss or malfunction of an organ without the restrictions of today's therapies.[1–12] Tissue engineering involves the culture of cells obtained from a small biopsy of a patient followed by the controlled growth of the cells in 3 D degradable scaffolds to create a new organ or tissue.[13] One common method of use is to implant biodegradable scaffolds for tissue ingrowth in-vivo to provoke direct tissue formation in-situ.[14,15] Biodegradable cell-seeded scaffolds have many of the advantages of auto-grafts as a golden standard, but without the problems associated with insufficient cell supply.
Modeling and optimizing a polycaprolactone/gelatin/polydimethylsiloxane nanofiber scaffold for tissue engineering: using response surface methodology
Published in The Journal of The Textile Institute, 2021
Mahdieh Dehghan, Mohammad Khajeh Mehrizi, Habib Nikukar
Polymers are biomaterials that could be used for tissue engineering (Ifkovits & Burdick, 2007). In the human body, interactions of cells and proteins from the tissues and organs, while what is called the ECM supports the cellular architecture and structure, and this function is in the scale of the micro and nano. However, in the progressed tissue engineering, scaffolds by mimicking ECM made from organic and inorganic materials to create proper media with cell interaction and proliferation support. Biocompatible and biodegradable organic materials are eligible for replacement of natural structure of the body with synthetic biodegradable scaffolds that act as temporary substitutes. The construction of an artificial ECM imitation scaffold to enhance and encourage cell proliferation requires the replacement of biocompatible biodegradable organic materials to replace the three-dimensional ECM natural geometry (Edmondson, 2013).
Polyurethane/nano-hydroxyapatite composite films as osteogenic platforms
Published in Journal of Biomaterials Science, Polymer Edition, 2018
Bailey K. Jackson, Austin J. Bow, Ganesh Kannarpady, Alexandru S. Biris, David E. Anderson, Madhu Dhar, Shawn E. Bourdo
Tissue engineering, a field that merges engineering with medical research, utilizes materials with complex bio-physico-chemical properties and living cells to either generate tissue in vitro or promote rapid tissue growth in vivo. With the development of materials that have tunable characteristics, new areas of tissue engineering research have emerged related to the regeneration of missing tissues due to trauma, disease, or military combat. Within this field, bone tissue engineering focuses on assisting bone growth, healing, or regeneration. Bone injuries often require prolonged periods of time to heal and can cause long-term problems if they do not heal properly. Simple fractures usually heal without complicated therapies, but complex fractures involving shattered or missing bone often require void filling, a scaffold to guide healing, or a construct to support the area and/or assist in healing.