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Advances in Regenerative Medicine and Nano-Based Biomaterials
Published in Suvardhan Kanchi, Rajasekhar Chokkareddy, Mashallah Rezakazemi, Smart Nanodevices for Point-of-Care Applications, 2022
K. Ganesh Kadiyala, P.S. Brahmanandam, Rajya Lakshmi Chavakula, Naresh Kumar Katari
Regenerative medicine is a branch related to molecular biology and tissue engineering which involves the process of regenerating the structure and functions of damaged human cells, tissues or organs. The main motto of regenerative medicine is to find a way to cure previously untreatable injuries and diseases [1]. It is one of the modern and most interesting fields in medical science. Encouraging outcomes of the research recommend the enormous medical potential and the progressive impacts on the economy and healthcare system. Most human tissues do not regenerate naturally; this explains why regenerative medicine engineering has a lot of importance today with promising alternative treatments. Here, the principle is simple; cells are gathered and introduced with or without alteration of their biological properties into the injured tissues. After reaching their maturity, these cells or tissues can be grafted. Regenerative medicine has applications in various health issues like cardiac insufficiency, blood vessels, osteoarthritis, diabetes, liver diseases, etc., which could be considered. The concept of regenerative medicine is an evolving multidisciplinary field connecting medicine, biology, chemistry, mechanics and engineering to transform the way to advance health and quality of life by reestablishing, maintaining or enhancing organ and tissue functions.
Rehabilitation Computing in Electronic Computing
Published in Parveen Berwal, Jagjit Singh Dhatterwal, Kuldeep Singh Kaswan, Shashi Kant, Computer Applications in Engineering and Management, 2022
Parveen Berwal, Jagjit Singh Dhatterwal, Kuldeep Singh Kaswan, Shashi Kant
Regenerative medicine is a growing discipline in medicine that combines biology and biomedical engineering concepts intending to create a functional tissue replacement that will preserve human tissue function. And the fact that soft tissues regenerate, bone healing has degenerative characteristics, and there is normally no scar after healing. The renovating process starts as soon as the fracture is bridged by fresh bone. Different stimuli, such as growth factors, distraction osteogenesis, and endothelial cells, can influence bone recovery. TGF-“3 is a cytokine released by a variety of cell types in the body that affects a variety of cell functions such as differentiating, stimulating mesenchymal stem cell (MSC) formation, acting as a chemotactic factor, and promoting bone cells and ECM product secretion. This section aimed to look into the effects of TGF-3 and its dose carriers HCl and BSA/HCl on MG63 bone cell monolayer wound repair.
The Emerging Role of Exosome Nanoparticles in Regenerative Medicine
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Zahra Sadat Hashemi, Mahlegha Ghavami, Saeed Khalili, Seyed Morteza Naghib
Stem cells are undifferentiated cells that could differentiate into specialised cell types (potency) and proliferate indefinitely with numerous cell growth cycles (self-renewal) (Hashemi et al. 2015; Hashemi et al. 2013; Molaabasi et al. 2020; Ghorbanzade et al. 2020). The use of stem cells is a highly established approach in regenerative medicine (Askari and Naghib 2020; Ghorbanzade and Naghib 2019). For instance, Embryonic Stem Cells (ESCs) can differentiate into more than 200 types of cells which could be used to restore a patient’s tissue from severe injuries or chronic diseases (Mahla 2016). The application of regenerative medicine could encompass the cell therapy (using the patient’s own cells or non-native donor cells), treatment with growth factors, applications of recombinant proteins, small molecules, and finally tissue engineering and gene therapy. The cell therapy method could be defined as the introduction of new cells into the tissue for disease treatment. These new cells often focus on the stem cells or mature, functional cells with or without genetic modification (gene therapy) for both kinds of cells (Wei et al. 2013).
Biocompatible conjugation for biodegradable hydrogels as drug and cell scaffolds
Published in Cogent Engineering, 2020
Regenerative medicine, which combines of tissue engineering and drug delivery, takes the multidisciplinary principles of materials science, medicine, and life science to generate tissues and organs of better biological structures and functions (J. Chen & Zou, 2019; Dragan & Dinu, 2019). Regenerative medicine is to implant scaffolding materials for tissue regeneration based on the recruitment of native cells into the scaffold, and subsequent deposition of extracellular matrix (ECM) (Dragan & Dinu, 2019; Ong et al., 2019). Cell scaffolds provide the initial structural support and retain cells in the pores for cell growth, metabolism and matrix production, thus playing an important role during the development of engineered tissues (Ong et al., 2019; Razavi et al., 2019). A major issue in the use of scaffolds and tissue reconstruction procedures in general, is that the establishment of a biomimic environment into the engineered tissue is necessary for tissue survival (Nuttelman et al., 2008; Razavi et al., 2019).
Dense lamellar scaffold, biomimetically inspired, for reverse cardiac remodeling: Effect of proanthocyanidins and glutaraldehyde
Published in Journal of Dispersion Science and Technology, 2021
Thais Alves, Juliana Ferreira Souza, Venancio Alves Amaral, Alessandra Candida Rios, Tais Costa, Kessi Crescencio, Fernando Batain, Denise Grotto, Renata Lima, Lindemberg Silveira Filho, Jose Oliveira Junior, Patricia Severino, Norberto Aranha, Marco Chaud
Regenerative medicine is an emerging field that aims in improving or repairing the performance of damaged tissue or organ. Numerous strategies, including the use of materials and cells, as well as various combinations thereof, to take the place of missing tissue, effectively replacing it both structurally and functionally, or to contribute to tissue healing.[3,4]