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Pseudomonas putida with Microbial Electrochemical Technologies
Published in Sonia M. Tiquia-Arashiro, Deepak Pant, Microbial Electrochemical Technologies, 2020
In a different study by the Rosenbaum group (Schmitz et al. 2015), a mediator-based electron transfer route was established in P. putida KT24440 using genetic engineering. Production of phenazines, which were reported as electron mediators secreted by Pseudomonas aeruginosa (Rabaey et al. 2005; Pham et al. 2008), was introduced into KT2440. Phenazines are a group of redox compounds with formal redox potentials of about -110 to 0 mV (vs. SHE) at a neutral condition (Price-Whelan et al. 2007; Seviour et al. 2015). Under microaerobic conditions, P. putida KT2440 could catabolize glucose, secrete phenazines and subsequently use them as electron mediators to shuttle the electron transfer from the cells to the anode. A slight accumulation of gluconic acid, 2-ketogluconic acid and acetic acid were observed, however, the majority of carbon ended up in biomass and CO2 that was similar to the aerobic metabolism of P. putida.
Biofilms in Oil Bioremediation
Published in Y.V. Nancharaiah, Vayalam P. Venugopalan, Microbial Biofilms in Bioremediation and Wastewater Treatment, 2019
Debdeep Dasgupta, Tapas K. Sengupta
Phenazines are large group of heterocyclic compounds secreted naturally by different bacterial species. More than 100 different phenazine structural derivatives have been identified as natural products and over 6,000 derivatives containing phenazine as a central moiety have been synthesized (Mavrodi et al. 2006). In recent years, the naturally occurring and synthetic phenazines are gaining significant interest because of their potential impact on bacterial interactions and biotechnological processes. The alteration of functional groups added to the phenazine ring determines the color, redox potential and solubility of compounds, thereby affecting their activities (Laursen and Nielsen 2004, Kerr 2000, Chin-A-Woeng et al. 1998). Phenazines are widely used as electron acceptors/donors, biosensors and reagents in fuel cells as well as antitumor agents. Phenazines are model compounds for studying biofilm and quorum sensing in Pseudomonas aeruginosa and other phenazine-excreting
Microwave-assisted Multi-component Reaction for the Green Synthesis of Novel 4-(5-hydroxybenzo[a]phenazin-6-yl)-5-phenyl-1, 3-dihydro-2H-imidazol-2-one Using H3PW12O40@nano-TiO2 as Recyclable Catalyst
Published in Green Chemistry Letters and Reviews, 2022
Milad Taheri, Zanko Hassan Jawhar
Phenazines are a large group of nitrogen-containing heterocyclic compounds that differ in chemical and physical properties. Phenazines are a class of redox-active secondary metabolites produced by a few clades of bacteria, most notably pseudomonads,20,22 but not cyanobacteria. Bacteria are the only known source of phenazines, and more than 100 types of these compounds have been identified. Their potential impact on bacterial interactions and biotechnological processes has been considered (Figure 1) (34,35). Natural phenazines are considered biologically active and are used in pigments and have many biological properties such as antioxidants (36), anti-AIDS (HIV) (37,38), anti-tumor (39,40), and the treatment of Alzheimer's and schizophrenia (40,41).
Multi-component reaction synthesis of novel 3-phenyl-3,4-dihydro-2H-benzo[a][1,3] oxazino[5,6-c]phenazine derivatives catalyzed by reusable ZnO-PTA@Fe3O4/EN-MIL-101(Cr) nanopowder at room temperature
Published in Green Chemistry Letters and Reviews, 2020
Milad Taheri, Razieh Mohebat, Mohammad Hossein Mosslemin
Phenazine compounds and derivatives are heterocyclic compounds that are readily found in nature and are among biological agents; these compounds are used in fungicides, anti-malarial (29) drugs, and anti-tumor activity (30). For example, benzo[a]phenazine-5-ol and pyridazinophenazinedione derivatives are antitumor agents (31).
Synthesis of one-pot pyrazolo[4′,3′:5,6]pyrano[2,3-c]phenazin-15-yl) methanone derivatives via a multi-component using Fe3O4@TiO2-SO3H as a recoverable magnetic catalyst under microwave irradiation
Published in Green Chemistry Letters and Reviews, 2020
The synthesis of organic matter with microwaves has revolutionized the science of chemistry. Small molecules can be synthesized in a short time by classical microwave irradiation. As a result, this method has gained much acceptance and is a valuable tool for drug discovery (10). Significant advantages of using microwaves in the synthesis are as follows: Greatly reduced reaction times due to the rapid reduction of heat (11,12).Higher efficiency achievable due to the efficient energy (13,14).It is possible to perform multiple reactions in the same unit of time using the same device (15,16). This technique is very useful when different types of compounds need to be prepared quickly (17,18).There is an increase in selectivity in reactions (19,20). Recently, the use of titanium oxide as a support for sulfonic acid has been investigated in our synthesized reactions. TSA is easily prepared via the addition of ClSO3H to a suspension of powdered TiO2 in dry CHCl3 (as indicated in the experimental section) (21,22). All reactions were carried out using TSA catalyst at a very good time and with excellent efficiency. Recently, the use of TSA-supported magnetic nano-particles as a heterogeneous Brønsted acid has been proposed. Due to the paramagnetic properties of this catalyst, it is possible to recycle the catalyst without the slightest reduction in its activity during the reaction. Environmentally friendly, easy catalyst synthesis, reusability and recycling by an external magnet and ability to neutralize it by water are some of the benefits of using nano-composites such as this catalyst which has encouraged scientists in the field of green chemistry to use Magnetic nano-particles (23,24).Phenazine compounds and derivatives are heterocyclic compounds that are readily found in nature and are among biological agents; these compounds are used in fungicides, anti-malarial drugs, and anti-tumor activity (25). To this end, a series of benzo[a]phenazines have been synthesized as anti-tumor agents. Also, benzo[a]phenazine derivatives are widely used in photodynamic therapy, in that they produce a combination of light and photosensitive photos of highly reactive oxygen species or hydroxyl radicals that selectively target tumors. One derivative of phenazines is benzo[a]phenazine-5-ol. They also have many biological properties such as antioxidants (26), anti-AIDS (27), anti-tumor (28,29) and treatment of Alzheimer's disease (30,31). The synthesis of benzo[a]phenazine-5-ol product is visible (Scheme 1) (32,33).