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Drug Side Effect Frequency Mining over a Large Twitter Dataset Using Apache Spark
Published in Saravanan Krishnan, Ramesh Kesavan, B. Surendiran, G. S. Mahalakshmi, Handbook of Artificial Intelligence in Biomedical Engineering, 2021
Dennis Hsu, Melody Moh, Teng-Sheng Moh, Diane Moh
Ibuprofen is a nonsteroidal anti-inflammatory drug. There is no past precedence of it causing emotional complications, abnormal highs, drowsiness, or binge eating disorders, although allergic rashes up to and including Stevens–Johnson syndrome and toxic epidermal necrolysis have been reported in the literature.
Pharmaceuticals
Published in James G. Speight, Handbook of Petrochemical Processes, 2019
Ibuprofen is a medication in the nonsteroidal anti-inflammatory drug (NSAID) class (NSAID class) that is used for treating pain, fever, and inflammation. Since the introduction of the drug in 1969, ibuprofen has become one of the most common painkillers in the world. Ibuprofen in an NSAID, and like other drugs of its class, it possesses analgesic, antipyretic, and anti-inflammatory properties. While ibuprofen is a relatively simple molecule, there is still sufficient structural complexity to ensure that a large number of different synthetic approaches are possible.
Communications
Published in Emmanuel Tsekleves, Rachel Cooper, Design for Health, 2017
Ibuprofen is one of the most often used medicines (Kaufman et al., 2002) and it is used for the relief of symptoms of pain, inflammation and fever (Rainsford, 2013). However, it is by no means harmless because side effects include kidney damage and ibuprofen can cause gastrointestinal bleeding.
The fabrication of multifunctional sodium alginate scaffold incorporating ibuprofen-loaded modified PLLA microspheres based on cryogenic 3D printing
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Lihua Zhao, Shunyu Chen, Chunling Xie, Qingshuang Liang, Dian Xu, Weixin Chen, Xiufeng Xiao
Polylactic acid (PLA) is a widely used biopolymer for fabricating drug-loaded microspheres because of its low cytotoxicity, good biodegradability and absorbability [25, 26]. However, the poor cell affinity due to its strong hydrophobicity limits its practical application to some extent, so a certain treatment to modify PLA substrates is required. It has been confirmed based on previous study that the modification of PLA substrates with hydrophilic groups such as -COOH, -OH and -NH2 would promote cell attachment, spreading and proliferation and the enhanced hydrophilicity due to the introduction of hydrophilic groups (NH2) through aminolysis reaction between PLA and ethanediamine could facilitate the formation of microspheres synthesized using the emulsion method [27–30]. Ibuprofen is a non-steroidal anti-inflammatory drug and is commonly used for pain relief, fever reduction and against inflammation [31]. IBU-loaded PLA microsphere can effectively delivery and sustained release drugs, so the as-prepared 3 D printed sodium alginate scaffold incorporating IBU-loaded modified PLLA microspheres would possess a long-term anti-inflammatory efficacy to meet the sustained need for bone tissue repair.
Effect of crystallizer design and operational parameters on the batch crystallization of ibuprofen I: experimental
Published in Indian Chemical Engineer, 2022
Achyut Pakhare, Channamallikarjun Mathpati, Vishwanath H. Dalvi, Jyeshtharaj Joshi, Raosaheb Patil, Ekambara Kalekudithi
Crystallization is a unit operation extensively used in food, chemical, and pharmaceutical industries [1]. Crystal size and morphology of the product strongly affect the downstream processes such as filtration and drying [2]. Also, crystal morphology influences the flowability, packing, compaction, syringability, suspension stability, bioavailability, and dissolution characteristics of a drug powder [3]. Ibuprofen, an anti-inflammatory drug, is extensively used for the treatment of rheumatism, arthritis, fever, etc. Ibuprofen exhibit different crystal morphology in different solvents, as well as the size and aspect ratio, affect the flowability. The poor flowability affects the downstream operations in commercial manufacturing processes. These problems can be addressed at the crystallization step.
Ibuprofen biodegradation by hospital, municipal, and distillery activated sludges
Published in Environmental Technology, 2020
Huang CY, Fu LH, Sung MH, Huang CF, Wu JP, Kuo HW
Ibuprofen (IBU) [2-(4-isobutylphenyl-propionic acid)] is a non-steroidal anti-inflammatory drug (NSAID) with analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory properties [1,2]. In human body, ibuprofen can bind with a cycloogygenase (COX) enzyme that can catalyse synthesis of hormone-like pain/fever-causing compounds, i.e. prostaglandins [3]. After its first clinical trials back in 1966 and its introduction in 1969, IBU has been widely used to treat pain, fever, and rheumatic disorders. Although having some adverse effects on the gastrointestinal tract and the kidney, ibuprofen has still been rated as the safest conventional NSAID by spontaneous adverse drug reaction reporting systems in the UK comparing with other pain-releasing drugs (e.g. aspirin or paracetamol); and, is one of the world’s most popular drugs with an estimated annual global production amount of more than 30,000 tons nowadays [4].