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Curcumin Nanomedicine and Their Application in the Management of Disease
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Sadaf Jamal Gilani, Syed Sarim Imam, Mohammed Jafar, Sultan Alshehri, Mohamad Taleuzzaman, Mohammed Asadullah Jahangir
The research group formulated curcumin nanoemulsion to assess the in-vivo anti-inflammatory activity and arthritic activity using carrageenan-induced paw edema and FCA induced arthritic rat model. The optimized curcumin nanoemulsion with emu oil was converted into carbopol gel and their biological activities were measured. The curcumin formulation in combination with emu oil showed significant improvement in anti-inflammatory activity and arthritic scoring, paw volume, biochemical, molecular, radiological, and histological examinations (Jeengar et al., 2016). The formulation of curcumin loaded self-nano emulsifying drug delivery system (SNEDDS) has been prepared and evaluated. The optimized formulation comprised of ethyl oleate:tween 80:PEG 600 (50:40:10% w/w) with 11. 2-nm uniform droplets showed a significant increment of 3. 95 times in Cmax, and the curcumin bioavailability was enhanced by 194. 2%, compared to the curcumin suspension in water (Nazari et al., 2017).
Role of Nanotechnology in Selective Targeting of Cancer
Published in Megh R. Goyal, Santosh K. Mishra, Lohith Kumar Dasarahalli-Huligowda, Nanotechnology Applications in Agricultural and Bioprocess Engineering, 2021
Curcumin and emu oil from emu birds have shown promising results against inflammation. The nanoemulsions were prepared using Cremophor, Labrafil, and emu oil. It showed good anti-inflammatory activity when mixed with curcumin [20]. For preparation of silver nanoparticles (AgNPs), the inexpensive, fast, and renewable strategy was performed in aqueous media utilizing light emitted as the catalyst. The prepared nanocomposite exhibited very high antimicrobial activity against various strains of microorganisms. Another green and clean strategy for the AgNPs preparation used the Delftia’s cell free suspension and demonstrated the both drug delivery agents and antifungal activities [26]. Ginsenoside NPs play important role in carrying insoluble drugs. Dai et al. [9] demonstrated that anticancer drug has enhanced in-vivo and in-vitro effects when loaded on ginsenoside NPs than the free drug.
Emergence of Nanovesicular Systems for Topical Delivery of Natural Bioactives
Published in Bhupinder Singh, Om Prakash Katare, Eliana B. Souto, NanoAgroceuticals & NanoPhytoChemicals, 2018
Gajanand Sharma, Kanika Thakur, Akanksha Mahajan, Guneet Singh Randhawa, Bhupinder Singh, Om Prakash Katare
NEs, composed of palm kernel oil, were loaded with P. urinaria extract and were characterized in terms of particle size, zeta potential and rheological properties. The in vitro release of the extract from the formulation showed 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and counteracting oxidative injury. The anti-inflammatory property of curcumin, in combination with emu oil, was investigated by developing a nanoemulgel formulation. NEs were prepared using emu oil, Cremophor RH 40 and Labrafil M2125CS as oil phase, surfactant, and co-surfactant. The arthritic scoring, paw volume, biochemical, molecular, radiological, and histological examination revealed significant improvement in anti-inflammatory activity using NEs compared with plain solutions of both curcumin and emu oil (Jeengar et al., 2016).
Evaluation of Nigella sativa oil loaded electrospun polyurethane nanofibrous mat as wound dressing
Published in Journal of Biomaterials Science, Polymer Edition, 2021
Cansu Aras, Elif Tümay Özer, Gökhan Göktalay, Gülbahar Saat, Esra Karaca
Polyurethane (PU) is widely used in medical applications due to its biocompatibility, non-toxicity, good barrier properties, gas permeability, and high efficacy in control of wound moisture [33–35]. Many studies have reported its usage in electrospun wound dressings [36–38]. In recent years, various researchers have investigated the wound healing effects of PU nanofibers containing essential oils such as murivenna oil [39], emu oil [40], olive oil [41], Channa striatus fish oil [42], lavender oil [43], and propolis and neem oils [44]. However, to the best of our knowledge, there is no report on the production of NSO loaded PU electrospun nanofibrous mats.
Updates in immunocompatibility of biomaterials: applications for regenerative medicine
Published in Expert Review of Medical Devices, 2022
Mahdi Rezaei, Farideh Davani, Mohsen Alishahi, Fatemeh Masjedi
As mentioned, incorporating the immunoregulatory agents into the biomaterials can be beneficial for immunomodulation. Vitamin D is one of the substances that can act as an immunomodulator for biomedical devices [149]. In this respect, Chen et al. prepared to align nanofibers incorporated with 25-hydroxyvitamin D3 to modulate the immune response. Their results showed that the local delivery of vitamin D3 by the nanofibrous scaffolds significantly reduced the expression of pro-inflammatory cytokines, including TNF-α and IL-6, whereas increased the expression of anti-inflammatory cytokines including IL-4 and IL-10 after subcutaneous implantation compared to pristine scaffolds [150]. Magnesium (Mg) is a biodegradable metal that possesses high biocompatible properties that can decrease inflammation and immune response, resulting in ameliorating tissue repair. Adhikari et al. fabricated PCL-nanofibers mesh incorporated with Mg metal particles. Results indicated that the addition of Mg particles moderates inflammatory tissue responses and enhances the healing process [151]. Immunomodulation of the nanofibers with the incorporation of the natural product also can be achieved as Zamani et al. investigate the effect of the Emu oil on the immune response of the nanofibers. The results showed that the Emu oil incorporation led to the polarization of the macrophages toward the M2 anti-inflammatory phenotype and resulted in a significant reduction in the pro-inflammatory cytokine secretion such as TNF-α, IL-1β, and IL-6 [152]. In another study, Kazantesva et al. investigated the effect of augmentation of nanofibers with graphene on biocompatibility and inflammation. Their results affirmed that the graphene augmented inorganic nanofibers decreased the secretion of pro-inflammatory cytokines and possessed a strong ability to modulate the immune response [153].