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Emerging Perspectives of Virtual Reality Techniques
Published in Christopher M. Hayre, Dave J. Muller, Marcia J. Scherer, Virtual Reality in Health and Rehabilitation, 2020
The alternative to opioids in many cases is non-opioid medications, such as non-steroidal anti-inflammatory drugs. However, there are concerns associated with nonsteroidal anti-inflammatory drugs, such as preventable adverse drug reactions that cause bleeding, heart attack, stroke, and renal damage (Davis and Robson, 2016). Thus, alternative pain management strategies are important to consider in an effort to mitigate some of these risks associated with opioid and non-opioid analgesic medications.
Development of Ophthalmic Formulations
Published in Sandeep Nema, John D. Ludwig, Parenteral Medications, 2019
Paramita Sarkar, Martin Coffey, Mohannad Shawer
Inflammation is the manifestation of vascular and cellular response of the host tissue to injury. Injury to the tissue may be inflicted by physical or chemical agents, invasion of pathogens, ischemia, and excessive (hypersensitivity) or inappropriate (autoimmunity) operation of immune mechanisms. In ocular tissues, inflammatory reactions are mediated by arachidonic acid cascade products formed via the cyclooxygenase pathway. There are two types of anti-inflammatory agents: corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs). Both corticosteroids and NSAIDs may be administered orally as well as topically, but topical administration is the preferred route for the management of ocular inflammation as it provides high ocular drug concentrations and reduces the systemic side effects.
in vivo evaluation of some bromonaphthyl pyrazolines as new anti-inflammatory agents
Published in Yuli Rahmawati, Peter Charles Taylor, Empowering Science and Mathematics for Global Competitiveness, 2019
Jasril, H.Y. Teruna, N. Frimayanti, S. Hasti, I. Ikhtiarudin
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the most commonly used drugs to treat inflammation because they are effective in the management of pain, fever, redness, and edema arising as a consequence of inflammatory mediator release (Ferreira, 2002). Some studies showed that both the therapeutic and the side effects of NSAIDs are dependent on the inhibition of cyclooxygenase (COX) (Warner et al., 1999). Many studies have reported that COX-2 inhibition is responsible for the therapeutic effects of NSAIDs, while COX-1 inhibition causes the gastrointestinal and renal side effects (Patrignani, 2000; Zhao et al., 2001).
Review: Schiff base metal complexes as anti-inflammatory agents
Published in Journal of Coordination Chemistry, 2023
Qurat-Ul-Ain Sandhu, Muhammad Pervaiz, Abdul Majid, Umer Younas, Zohaib Saeed, Adnan Ashraf, Rana Rashad Mahmood Khan, Sami Ullah, Faisal Ali, Seemal Jelani
Most anti-inflammatory drugs are extracted from plant sources to get relief from pain and fever. Non-steroidal anti-inflammatory drugs (NSAIDs) are used as anti-inflammatory drugs. NSAIDs are generally composed of organic acids and later non-acidic compounds. Some anti-inflammatory drugs show less gastrointestinal side effects as compared to predecessors like aspirin and indomethacin [77]. The main function of NSAIDs is to block the COX enzyme and suppress the activity of prostaglandin. Two types of COX enzymes are known, COX-1 provides protection in gastrointestinal tract while COX-2 performs inflammatory signal activity [78].
Unmodified and rGO-modified Zn/Al layered double hydroxides; nanoadsorbents employed for the solid phase extraction/HPLC determination of naproxen
Published in Journal of Dispersion Science and Technology, 2023
Maryam Afshar, Leila Dolatyari, Payam Soheili-Azad, Mir Saeid Seyyed Dorraji, Mohammad Reza Yaftian
Nonsteroidal anti-inflammatory drugs are well-known as medicines prescribed widely for the treatment of chronic,[1] menstrual, postoperative, arthritic rheumatoid, and osteoarthritis pains.[2] Naproxen (6-methoxy-α-methyl-2-naphthyl-acetic acid) is a member of this group of drugs, with the potential to be used in cancer treatment and prevention.[3] The acid nature of this compound (pKa 4.15[4]) allows to control its neutral or charged species by adjusting the solution pH.
Porphyrin-like porous nanomaterials as drug delivery systems for ibuprofen drug
Published in Molecular Physics, 2020
Jiali Gao, Chunyan Guo, Xin Wang, Wenxu Zhang, Yang Wang, Vahid Vahabi
Ibuprofen (Ibp), 2-(4-isobutylphenyl) propionic acid, is a non-steroidal anti-inflammatory drug that is utilised widely in the treatment of chronic pain and inflammation [42]. Previous studies of non-steroidal anti-inflammatory drugs like Ibp have revealed on their dissolution [43–45], solubility [46], release [47] and other thermodynamic properties [43,48] of the drugs. It was also demonstrated that Ibp can delay the deposition of Alzheimer plaque in mice [49]. However, oral consumption of non-steroidal anti-inflammatory drugs like Ibp causes a number of harmful side effects including gastrointestinal aggravation, ulceration, and in some cases, bleeding [50]. The controlled release of Ibp can be helpful for a formulation of a drug delivery system particularly in high dose treatments for diseases like rheumatoid arthritis. The use of nanomaterials as drug delivery systems is a couple of examples of attempts to help to control the release of Ibp to improve bioavailability while reducing its common side effects. Given the advantages of nanomaterial-drug mixtures in solubilisation over their pure components, it may be possible for an appropriate mixture of the drug and a nanocarrier to increase the bioavailability of the non-steroidal anti-inflammatory drug. Previously, various materials as carrier for Ibp delivery system have been suggested [51,52]. In this work, in order to search for new Ibp delivery system, we investigate the interaction of Ibp with FeN4C55, FeN4CNT and FeN4G. The main objective of this study is to explore theoretically FeN4C55, FeN4CNT and FeN4G systems to search the possibility of controlled delivery of non-steroidal anti-inflammatory drugs like Ibp. The values of adsorption energy, molecular electrostatic potentials, electronic properties, density of states and ultraviolet–visible (UV–Vis) spectra of the systems were calculated and analysed. Moreover, properties extracted from the quantum theory of atoms in molecules (QTAIM) were utilised to determine the nature of interactions.