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Overview of Carbon-Ion Radiotherapy in Japan
Published in Manjit Dosanjh, Jacques Bernier, Advances in Particle Therapy, 2018
Hirohiko Tsujii, Tadashi Kamada
Soft-tissue sarcomas develop from the soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. They can be found in any part of the body, and most of them develop in the arms or legs. They also develop in the trunk, head and neck and retroperitoneum, which are the major candidates for CIRT. The five-year LC and five-year OS for unresectable retroperitoneal tumours (n = 24) was 69% and 50%, respectively [14]. Considering that most patients were not eligible for surgical resection and had high-grade sarcomas, these results are very promising.
Pesticide exposure and genotoxic effects as measured by DNA damage and human monitoring biomarkers
Published in International Journal of Environmental Health Research, 2021
Jones A. Kapeleka, Elingarami Sauli, Patrick A. Ndakidemi
Due to their genotoxic and mutagenic capacity, the use of pesticides without necessary protection is associated with alterations in the genetic material and probable development of tumors (Gundogan et al. 2018; Hilgert Jacobsen-Pereira et al. 2018). Population living in areas with high pesticide use have an increased risk of different types of cancer (Parrón et al. 2013). Parkinson disease, Non-Hodgkin’s lymphoma, multiple myeloma, soft-tissue sarcoma, lung sarcoma, pancreatic, skin, brain, stomach, liver, bladder and gall bladder cancer, prostate cancer, and reproductive outcomes are all linked to pesticides exposure (Mathur et al. 2005; Kapka-Skrzypczak et al. 2011; Singh et al. 2011; Hernandez et al. 2013; Hongsibsong et al. 2017; Sabarwal et al. 2018).These health risks depends not only on how toxic the pesticide is, but also on the level of exposure (Kim et al. 2016). The duration of exposure and concentration of pesticides adsorbed in blood influences the intensity of detrimental effects of pesticides (Hayat et al. 2018). Long-term pesticide exposure is also associated with increased abnormality of nerve conductions especially in sensory nerves (Hu et al. 2015).
Loading of doxorubicin on poly(methyl methacrylate-co-methacrylic acid) nanoparticles and release study
Published in Journal of Biomaterials Science, Polymer Edition, 2021
Roberto López-Muñoz, María Esther Treviño, Fabiola Castellanos, Graciela Morales, Oliverio Rodríguez-Fernández, Santiago Saavedra, Angel Licea-Claverie, Hened Saade, Francisco Javier Enríquez-Medrano, Raúl Guillermo López
DOX is used as a first-line treatment for a wide spectrum of cancers, such as: breast, ovarian, testicles, lung, bladder, and stomach; also, it is used for clinical treatments such as: lymphomas, acute leukemia, solid tumors, Kaposi's sarcoma and soft tissue sarcoma [1, 2]. One of the main problems with this anticancer agent is that it does not specifically target cancer cells also affecting healthy tissue, causing toxicity and side effects that limit its maximum tolerable dose [2–5]. To avoid these complications, an attempt has been made to load DOX into various nanostructures, some of them made of polymers [6–19], trying to improve its pharmacokinetics and pharmacodynamics in order to achieve greater efficiency in cancer treatment with a minimum of adverse side effects. Bellow we present a brief analysis of some of the most important reports on the preparation of DOX-loaded polymeric NP.
New metal-based drugs: spectral, electrochemical, DNA-binding and anticancer activity properties
Published in Inorganic and Nano-Metal Chemistry, 2021
Mustafa Çeşme, Harun Muslu, Mehmet Tumer, Özge Güngör, Mine Altunbek, Mustafa Culha, Aysegul Golcu
DAC (5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide) (Scheme 1) methylates guanine (G) at the oxygen-6 and nitrogen-7 positions, and thus cells cannot divide. The effect on cancer cells is higher than that of healthy cells since cancer cells divide faster even though some of the healthy cells can still be damaged.[7,8] It is used treatment of various cancers, including melanoma, soft tissue sarcoma, lymphoma.