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in vivo measurements
Published in Wojciech Pietraszkiewicz, Wojciech Witkowski, Shell Structures: Theory and Applications Volume 4, 2017
I. Lubowiecka, A. Tomaszewska, K. Szepietowska, C. Szymczak, M. Lichodziejewska-Niemierko, M. Chmielewski
Patients suffering from the end-stage kidney disease, treated with peritoneal dialysis in Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, have been investigated. During the procedure the patient lays in the supine position (Figure 1). Three markers are placed on both sides of the patient on the horizontal plane in order to identify the patient position in 3D space during the measurements. The procedure described here starts when the patient’s abdominal cavity is emptied from previous liquid (position 0). A regular net of points 2 × 2 cm is marked on the abdomen for displacements field identification (Figure 1). A region of an indwelling catheter is excluded as it is covered by a bandage. During a routine peritoneal dialysis a maximum of 2000 ml of dialysis fluid is infused into the peritoneal cavity through an indwelling catheter. Intraabdominal pressure is measured by a graduated column (cm) bounding to the abdominal cavity through the catheter (see Dejardin et al. 2007) when the abdomen is filled by liquid (position 1).
Application to GFR Estimation
Published in Yunong Zhang, Dechao Chen, Chengxu Ye, Toward Deep Neural Networks, 2019
Yunong Zhang, Dechao Chen, Chengxu Ye
In this chapter, we use the data of Chinese patients with CKD from the Division of Nephrology, Department of Internal Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China from January 2005 to December 2010. The total data contain 1180 individuals with 8 characteristics which consist of 7 inputs (i.e., sex, age, height, weight, albumin, serum creatinineserum creatinine, and urea) and 1 output (i.e., GFR). The data-sets with detailed characteristics can be referred to in Zhang et al. [269]. Without loss of generality, the 7 inputs/attributes and 1 output have been normalized to the range [-1,1] before using the WASD algorithm in numerical studies.
Expert Systems in Medicine
Published in Jay Liebowitz, The Handbook of Applied Expert Systems, 2019
Experts systems were applied to the following medical fields in the 1990s: surgery (acute abdominal pain), microbiology (borreliosis), radiology (thoracic diseases), pharmacology, neurosurgery (meningitis), anesthetics and intensive care, pediatrics (metabolic diseases), neurology (cerebrovascular diseases), laboratory medicine (diseases of the thyroid gland, borreliosis, nephrology), internal medicine (rheumatology, diabetes mellitus, nephrology, hepatology), opthomology, physiology, and dentistry. A list of the selected applications are included in the Appendix.
From portable dialysis to a bioengineered kidney
Published in Expert Review of Medical Devices, 2018
Maaike K. van Gelder, Silvia M. Mihaila, Jitske Jansen, Maarten Wester, Marianne C. Verhaar, Jaap A. Joles, Dimitrios Stamatialis, Roos Masereeuw, Karin G. F. Gerritsen
Recognizing the need for clinical trials and the unmet medical needs of patient with kidney failure, the American Society of Nephrology and the US Food and Drug Administration (FDA) established the Kidney Health Initiative (KHI) in 2002 under a Memorandum of Understanding [116–118]. The KHI, a public–private partnership, is designed to establish a collaborative environment for all stakeholders in the kidney community (academics, patient organizations, regulators, industry, healthcare providers, foundations, pharmaceutical and biotechnological companies, dialysis providers, and US and international governamental agencies) to interact and help foster development of innovative therapies for kidney diseases [116]. By adopting a proactive approach, KHI intends to facilitate availability of the right drug, device or biologic to the right patient at the right time [119,120]. Also non-US stakeholders participate in the KHI, including the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA), the Dutch Kidney Foundation, the Institute Kidney Foundation of Delhi and Frenesius Medical Care (Germany), world’s largest dialysis provider. In addition, the FDA has selected two renal device projects, in 2012 the Kidney Project and in 2015 the WAK, to participate in a new regulatory approval program (Expedited Access Pathway, EAP) that intends to speed-up the process of bringing breakthrough medical device technologies to patients [105,118,121–123].
Effects of intradialytic exercise on functional capacity in patients with end-stage chronic kidney disease: a systematic review and meta-analysis
Published in Research in Sports Medicine, 2022
Aline M. Araujo, Rafael B. Orcy, Natan Feter, Marina K Weymar, Rodrigo K. Cardoso, Maristela Bohlke, Airton J. Rombaldi
The selection of the terms used during the review process was conducted based on the Medical Subject Headings (MeSH) and in the specialized literature. To combine the descriptors and terms, the logical operators “AND” and “OR” were used. The following terms were used, in English, with the respective combinations: (”haemodialysis” OR “haemodialysis” OR “hemofiltration” OR “haemofiltration” OR “dialysis” OR “renal replacement therapy” OR “nephrology” OR “ nephron, kidney” OR “renal disease” OR “renal failure”) AND (“aerobic exercise” OR “aerobic training” OR “resistance training” OR “resistance exercise” OR “strength training” OR “anaerobic exercise” OR “physical training” OR “intradialytic exercise” OR “endurance” OR “rehabilitation”).
Cross-shift change of acute kidney injury biomarkers in sugarcane farmers and cutters
Published in Human and Ecological Risk Assessment: An International Journal, 2020
Ritthirong Pundee, Pornpimol Kongtip, Noppanun Nankongnab, Sirirat Anutrakulchai, Mark Gregory Robson, Susan Woskie
Chronic kidney disease (CKD) is a public health problem worldwide. The global prevalence of CKD was 9.1% (Carney 2020). CKD gradually develops over months to years, and is associated with hypertension, diabetes, and obesity (Fored et al. 2001; Kovesdy et al. 2017; Dash et al. 2018). However, in the last decades, a high prevalence of CKD of unknown etiology (CKDu) has been reported in some agricultural communities, including Meso-America, Sri Lanka, India, Egypt, and Tunisia (Gifford et al. 2017). The causes of CKDu are not known; they could be heat, pesticides, water (including heavy metals), infections, or other factors (Pearce et al. 2019). In Thailand, the number of peritoneal dialysis and hemodialysis cases has increased from 44,404 to 78,348 with age ranging 55–64 years from 2011 to 2015 (Nephrology Society of Thailand 2015). The etiology of patients undergoing dialysis varied and included 38.57% diabetic nephropathy, 30.71% hypertension nephropathy, 20% CKDu, and 11.59% of other cases (Nephrology Society of Thailand 2015; Gifford et al. 2017). It has been proposed that major risk factors for CKDu include dehydration and heat stress, which could induce acute kidney injury (AKI) and increase urinary neutrophil gelatinase-associated lipocalin (NGAL), urine specific gravity and serum creatinine (sCr) while estimated glomerular filtration rate (eGFR)and urine pH are decreased ( García-Trabanino et al. 2015; Wesseling, et al. 2016a; Kupferman et al. 2018). AKI is defined following KDIGO definition is a subcategory of Acute Kidney Disease, AKD): oliguria for >6 h, rise in SCr level by >0.3 mg/dl in 2 days or by >50% in 1 week. The AKD is defined as AKI, or GFR <60 ml/min per 1.73 m2, or markers of kidney damage for ≤3 months, or decrease in GFR by ≥35% or increase in serum creatinine by >50% for ≤3 months (Levey et al 2020).