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Applications of Silica-Based Nanomaterials for Combinatorial Drug Delivery in Breast Cancer Treatment
Published in Yasser Shahzad, Syed A.A. Rizvi, Abid Mehmood Yousaf, Talib Hussain, Drug Delivery Using Nanomaterials, 2022
Mubin Tarannum, Juan L. Vivero-Escoto
Nanotechnology has evolved to be at the forefront of diagnostics, imaging, and therapeutic drug delivery. Nanomaterials are applied in a plethora of scientific areas by virtue of their unique properties associated with the nanoscale, such as surface area and quantum effect (Vieira and Gamarra 2016). Nanomedicine brings nanotechnology and medicine together to improve current diagnosis and treatment as an effective solution to address some of the critical issues associated with cancer. Nanomaterials such as liposomes, albumin-based nanoparticles, polymeric nanoparticles, micelles, gold, and silica nanoparticles have been extensively used to develop novel imaging probes and therapies to improve cancer treatment (Sailor and Park 2012; Zhu et al. 2017). The applications of nanomedicine have made their way to the benefit of cancer patients with products like Doxil, Abraxane, and MM-398; additionally, many other platforms are under clinical investigation (van der Meel, Lammers, and Hennink 2017).
Plant Product-Based Nanomedicine for Malignancies: Types and Therapeutic Effects
Published in Khalid Rehman Hakeem, Majid Kamli, Jamal S. M. Sabir, Hesham F. Alharby, Diverse Applications of Nanotechnology in the Biological Sciences, 2022
Zuha Imtiyaz, Tabish Mehraj, Andleeb Khan, Mir Tahir Maqbool, Rukhsana Akhter, Mufeed Imtiyaz, Wajhul Qamar, Azher Arafah, Muneeb U. Rehman
Nanomedicine is the science of nanotechnology dealing with nanoscale materials and systems, which display unique and better biological, physical, and chemical characteristics, used for the identification, control, and treatment of diseases (Soares et al., 2018). The growth in the field of nanomedicine technology can improve the treatment conditions and diagnosis by utilizing the unique characteristics of engineered nanoparticles to recognize the specific markers of the diseases and to deliver the drugs to their respective target sites (Kim et al., 2010; Weiss, 2009; Davis et al., 2010). Using nanotechnology in the field of medicine is advantageous from drug delivery to their efficacy. Numerous properties of nanoparticles, which include the electrical, optical, and magnetic, could be controlled through altering their shape, size, physicochemical properties, and surface characterization, etc. Due to their flexible tunable properties, it allows the researchers and scientists around the world to create enormous amounts of materials with distinct properties and advantages to tailor the engineering of biomedical, diagnostic, and electronic devices (Zhang et al., 2016).
Biobased Nano Materials (Plant-based for Green Materials) Synthesis, Properties and Their Application in Biomedical Science
Published in Sarika Verma, Raju Khan, Avanish Kumar Srivastava, Advanced Nanocarbon Materials, 2022
Nanomedicine involves nanomaterials with applications in the biological and clinical fields, having a significant impact on unique innovations and advanced processes of disease therapy, sensing, and diagnosis (Rizzo et al., 2013, Ovais et al., 2018, Mukherjee et al., 2016). Recently, scientists worldwide have been working on the fabrication and design of such nanomaterials and their investigations to identify desired therapeutic and biological effects. Aimed at different biomedical applications, such as photothermal treatment, drug delivery, nanocomposites, medical imaging, etc., many nanoparticles like polymer nanoparticles (Elsabahy and Wooley, 2012), quantum dots (Fang et al., 2012), carbon nanotubes (Mocan et al., 2017), dendrimers (Svenson and Tomalia, 2006), and liposomes (Bozzuto and Molinari, 2015), as well as inorganic metal nanoparticles (Barui et al., 2017, Nethi et al., 2019), have been established. The nanoparticles have shown excellent applications in biomedicine, which is attributed to the nanoscale characteristics of the material as compared with the bulk scale.
Mathematical investigation of drug dispersion in the blood flow through Stenotic-Aneurysm tapered blood vessel
Published in International Journal of Modelling and Simulation, 2023
J V Ramana Reddy, Hojin Ha, S Sundar
Nanotechnology offers enormous potential to advance biological and pharmaceutical materials research. Several researchers have recently been interested in the study of nanoparticles. They are actively researching nanoparticle applications in medicine, including synthetic materials and naturally-occurring bionanomaterials such as viral nanoparticles (VNPs) [7]. The word ‘Nanomedicine’ was developed to refer to the medical use of nanotechnology, namely the creation of new nanomaterials for disease detection and therapy. The nanoparticles recognize the biomacromolecule using artificial receptors, which might be used to regulate biological activities such as sensing. The sensing process is divided into two stages: transduction and detection of the mobilized element. Temperature-sensitive drug-coated nanoparticles are adopted for the study. The temperature used will influence medicine distribution in the affected zone. Polymers, metal-organic frameworks (MOFs), covalent organic frameworks (COFs), porous materials, and nanoparticles are the most often used carriers for drug delivery to the desired target. Because the quantity of drug entangled with the nanoparticle’s surface roughness is modest, MOFs will be utilized to improve the amount of drug transduction to the targeted location. Barkat et al. [8] investigated drug delivery through nanofluid, with the base fluid combining water and glycerol. The authors used the drug delivery technique to treat urticaria, which has already been tested on animals.
Biogenic synthesis of selenium nanoparticles, characterization and screening of therapeutic applications using Averrhoa carambola leaf extract
Published in Particulate Science and Technology, 2023
Madhu Prakash Ganeshkar, Manisha Rajendra Mirjankar, Parashuram Shivappa, Anjana Thatesh Gaddigal, Premakshi Huchrayappa Goder, Chandrappa Mukappa Kamanavalli
Nanotechnology is an evolving field for the development of novel composites into a new range product and their applications (Shi et al. 2010). It mainly deals with the handling of materials at atomic and molecular level (Mittal et al. 2016). NPs are the particles with 10−9 size which have unique features like small size, high surface area, surface charge, surface chemistry, solubility and multi-functionality. Because of their unique properties NPs prove their case strongly as drug carriers by the huge success in the delivery of therapeutic molecules to the tangent sites (Moghimi, Hunter, and Murray 2005). Photocatalytic and magnetic stability of two-dimensional nanomaterials is enhanced by metal doping, which is an environmentally friendly technique used in various industries (Akbar et al. 2022). Nanostructures including liposomes, dendrimers, polymers, silicon, metal nanoparticles and carbon based nanoparticles have been used as beneficiary successful therapeutic agents and drug delivery carriers (Khurana et al. 2019). Nanomedicine is the application of nanotechnology plays an important role in medical research, clinical practice for the treatment, diagnosis, monitoring and control of biological reactions (Moghimi, Hunter, and Murray 2005). NPs have the ability to solve many of the biopharmaceutical and pharmacokinetic impediments associated with drugs in a variety of diseases like boosting the therapeutic efficiency of ionized drugs, improving the penetration of water-soluble compounds, proteins, peptides, vaccines, siRNA, mRNA, DNA and other targeted biological therapeutics (Sperling and Parak 2010).
Bamboo leaves: sustainable feedstock in pharmaceuticals, food, and agricultural sector
Published in Environmental Technology Reviews, 2022
Sarika Verma, Medha Mili, Vaishnavi Hada, Pranjal Kalita, S. A. R. Hashmi, S. K. S. Rathore, A. K. Srivastava
In this review article, we focused the role of bamboo leaves as sustainable feedstock in pharmaceuticals, food, and agricultural sectors. The importance of bamboo plants and leaves has been highlighted in detail. Bamboo leaves can be used in various forms like bamboo leaves essential oil (BLEO), Bamboo leaves ash (BLA), or by extracting medicinal chemicals. This review aims to acknowledge and bring forward scientific advancements in using the bamboo leaves as an initial raw material. This will fill the gap between the previous knowledge and the latest trends in the research community in developing emerging materials by using various chemical constituents present in the bamboo leaves by novel processing and approaches. We have comprehensively summarized the various ways to boost the applications and the utilization of bamboo leaves for diverse sectors. It can also inhibit activating carcinogens, detoxifying them, and protecting the DNA from oxidative damage, leading to malignant tumours. Bamboo leaf extract has also shown the properties to control diabetes and the production of acrylamide from different food additives, which is considered carcinogenic. Phytochemicals and polyphenols are obtained from bamboo leaves, but other nano-particles like silver and silica are also obtained. Nanoparticles in current research are used for drug delivery, and nanomedicine is even used in food technology, as pathogens are becoming resistant to antibiotics.